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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Maxillofacial Surgery—Historical and Future Perspectives and Controversies

edited by

Kamil Nelke

Maciej Dobrzyński

and

Michał Gontarz

submission deadline 25 May 2026 | 2 articles | Viewed by 1703 | Submission Open

Keywords: oral oncology; facial skeleton; oral cavity; surgical approaches; head and neck; parotid tumors; jaw cysts and tumors; bone healing; patient-specific solutions; surgery planning; artificial intelligence; soft tissues; cancers and tumors of the oral cavity; microsurgery perspectives; open surgery; endoscopic surgery; trauma surgery; facial traumatology; bone and soft tissues healing after trauma; jaw deformities; orthognathic surgery today and tomorrow

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Innovative Technologies and Approaches in Eye Disease Management and Refractive Surgery

edited by

Hidenaga Kobashi

submission deadline 25 May 2026 | 1 articles | Viewed by 1578 | Submission Open

Keywords: multifocal intraocular lenses; femtosecond lasers; artificial intelligence; imaging; eye surgery; refractive surgery

(This special issue belongs to the Section Ophthalmology)

Approaches and Challenges in Oral Rehabilitation

edited by

Yoko Hasegawa

and Takayuki Kosaka

submission deadline 25 May 2026 | 2 articles | Viewed by 1534 | Submission Open

Keywords: oral rehabilitation; oral health; systemic health; dental innovation; neuroplasticity

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Prediction, Diagnosis, and Treatment of Ovarian Cancer and Other Gynecologic Tumors

edited by Eleni T. Timotheadou and Emmanouil Saloustros

submission deadline 25 May 2026 | 2 articles | Viewed by 1452 | Submission Open

Keywords: ovarian; endometrial; cervical; chemotherapy; immunotherapy; primary debulking surgery; interval debulking; fertility-sparing surgery; PARP inhibitors; radiotherapy; HIPEC; sex cord tumors; dysgerminoma; leiomyosarcoma; liquid biopsies; circulating tumor cells; ctDNA

(This special issue belongs to the Section Obstetrics & Gynecology)

New Insights in Paediatric Endocrinology

edited by

Marco Fiore

submission deadline 25 May 2026 | 2 articles | Viewed by 915 | Submission Open

Keywords: endocrinology; pediatrics; hormones; therapy and treatment; adolescents; newborns

(This special issue belongs to the Section Clinical Pediatrics)

Advances in Ablation Therapy for Atrial Fibrillation: Innovations and Clinical Applications

edited by Ioanna Koniari

submission deadline 25 May 2026 | 2 articles | Viewed by 890 | Submission Open

Keywords: atrial fibrillation; ablation; PFA; PVI; non-thermal energy; mapping system

(This special issue belongs to the Section Cardiology)

Multiple Sclerosis and Demyelinating Disease: Clinical Treatment and Management

edited by Sotirios Giannopoulos

submission deadline 25 May 2026 | 1 articles | Viewed by 793 | Submission Open

Keywords: multiple sclerosis; demyelinating disease; comorbidities; disease modifying treatments; neuromuscular disorder; myasthenia gravis

(This special issue belongs to the Section Clinical Neurology)

Interstitial Lung Diseases: New Treatments Based on Treatable Traits

edited by Francesco Amati

submission deadline 25 May 2026 | 1 articles | Viewed by 744 | Submission Open

Keywords: interstitial lung diseases; progressive pulmonary fibrosis; phenotypes; endotypes; treatment; precision medicine

(This special issue belongs to the Section Respiratory Medicine)

Anemia: Clinical Updates in Diagnosis, Management, and Treatment

edited by

Joan-Lluis Vives-Corrons

submission deadline 25 May 2026 | 1 articles | Viewed by 619 | Submission Open

Keywords: anemia; diagnostic tools; hematology; artificial intelligence; targeted therapy; hereditary hemolytic anemia

(This special issue belongs to the Section Hematology)

Transcatheter Aortic Valve Implantation- Clinical Management and Future Challenges

edited by Mohamed Farag

submission deadline 25 May 2026 | 1 articles | Viewed by 611 | Submission Open

Keywords: transcatheter aortic valve implantation; TAVI; bicuspid aortic valve; small annulus; prosthesis– patient mismatch; coronary reaccess; valve-in-valve TAVI; leaflet modification

(This special issue belongs to the Section Cardiovascular Medicine)

New Advances in Congenital Heart Disease

edited by

Efrén Martínez-Quintana

submission deadline 25 May 2026 | 1 articles | Viewed by 539 | Submission Open

Keywords: congenital heart disease; pediatric cardiology; adult congenital heart disease; cardiac surgery; interventional cardiology; long-term outcomes; cardiac imaging

(This special issue belongs to the Section Cardiology)

Current Perspectives on the Clinical Management of Respiratory Diseases

edited by

Pradeesh Sivapalan

and

Alexandr Ceasovschih

submission deadline 25 May 2026 | 1 articles | Viewed by 513 | Submission Open

Keywords: COPD; acute exacerbations; biomarkers; clinical trials; bronchiectasis; respiratory infections

(This special issue belongs to the Section Respiratory Medicine)

Non-Small Cell Lung Cancer (NSCLC): Recent Advances in Clinical Diagnosis and Treatment

edited by

Cesare Guida

submission deadline 25 May 2026 | 1 articles | Viewed by 400 | Submission Open

Keywords: novel screening tool; cancer biomarkers; predictive marker of immunotherapy; targeted therapy; radiotherapy; non-small cell lung cancer

(This special issue belongs to the Section Oncology)

Anesthesia and Perioperative Management of Organ Transplants

edited by

Uzung Yoon

and Ji-Hye Kwon

submission deadline 25 May 2026 | Viewed by 348 | Submission Open

Keywords: liver transplantation; coagulation; reperfusion syndrome; perioperative evaluation; coronary artery disease; CDC; DBD; living donor liver transplant; pulmonary evaluation; hepatorenal syndrome; portopulmonary hypertension

(This special issue belongs to the Section Anesthesiology)

Surgical Innovation and Clinical Outcomes in Plastic and Reconstructive Surgery

edited by Pari Naz Mohanna and Ayush Kapila

submission deadline 25 May 2026 | 1 articles | Viewed by 264 | Submission Open

Keywords: plastic and reconstructive surgery; microsurgery; breast reconstruction; surgical innovation; novel flap techniques

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

High-Risk Neuroblastoma and Rhabdoid Tumors: New Clinical Insights and Challenges (Second Edition)

edited by

Rupert Handgretinger

and Johannes Hubertus Schulte

submission deadline 25 May 2026 | Viewed by 181 | Submission Open

Keywords: neuroblastoma; rhabdoid tumor; autologous stem cell transplantation; allogeneic stem cell transplantation immunotherapy; anti-GD2 antibody; targeted therapy; CAR T-cells

(This special issue belongs to the Section Oncology)

How Clinicians See the Use of AI in Psychiatry

edited by

Georgios Floros

submission deadline 25 May 2026 | Viewed by 132 | Submission Open

Keywords: artificial intelligence; psychiatry; patient care; psychotherapy

(This special issue belongs to the Section Mental Health)

Clinical Advances and Challenges in Vascular and Endovascular Medicine: 2nd Edition

edited by

Luca Bertoglio

submission deadline 25 May 2026 | Viewed by 104 | Submission Open

Keywords: vascular and endovascular medicine; minimally invasive cardiovascular surgery; vascular diseases; endovascular technologies

(This special issue belongs to the Section Vascular Medicine)

Clinical Advances in the Management of Abdominal and Thoracoabdominal Aortic Aneurysms

edited by

Daniela Mazzaccaro

submission deadline 25 May 2026 | Viewed by 103 | Submission Open

Keywords: abdominal aneurysm; thoraco-abdominal; computed-tomography angiography; branched endograft; branched endovascular aortic repair; fenestrated endograft; open surgery; 3-D printing

(This special issue belongs to the Section Vascular Medicine)

Advancing Trends and Strategies in Vascular and Endovascular Surgery

edited by Karin Pfister and Fiona Rohlffs

submission deadline 25 May 2026 | Viewed by 100 | Submission Open

Keywords: vascular surgery; endovascular surgery; carotid endarterectomy; peripheral vascular diseases; vascular imaging; aortic diseases; aortic aneurysm; arteriovenous malformation; pelvic venous disorder; endovenous procedures; pal-liative therapy concept

(This special issue belongs to the Section Vascular Medicine)

Clinical Advances in Personalized Psychiatry

edited by

Rosaria Di Lorenzo

submission deadline 25 May 2026 | Viewed by 96 | Submission Open

Keywords: personalized psychiatry; biomarkers; predictive modeling; precision diagnosis; neuroimaging biomarkers; effective treatments

(This special issue belongs to the Section Mental Health)

Clinical Diagnosis and Treatment of Demyelinating Diseases

edited by

Dimitrios Tzanetakos

and John S. Tzartos

submission deadline 25 May 2026 | Viewed by 96 | Submission Open

Keywords: demyelinating diseases of the CNS; demyelinating diseases of the PNS; multiple sclerosis; neuromyelitis optica spectrum disorder (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); clinical diagnosis; biomarkers; therapeutics

(This special issue belongs to the Section Clinical Neurology)

Advances in the Clinical Management of Diabetic Retinopathy

edited by

Takeshi Iwase

submission deadline 25 May 2026 | Viewed by 95 | Submission Open

Keywords: retinal imaging; clinical outcomes; optical coherence tomography (OCT); vitrectomy; blood flow

(This special issue belongs to the Section Ophthalmology)

Musculoskeletal Imaging and Intervention: 2nd Edition

edited by

Miguel Malo-Urriés

and

Jacobo Rodríguez-Sanz

submission deadline 25 May 2026 | Viewed by 95 | Submission Open

Keywords: ultrasound; invasive physiotherapy; minimally invasive surgical procedures; magnetic resonance; image analysis

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Acute and Chronic Heart Failure: Clinical Updates and Perspectives—2nd Edition

edited by Luigi Cappannoli and Cristina Aurigemma

submission deadline 25 May 2026 | Viewed by 88 | Submission Open

Keywords: acute heart failure; chronic heart failure; devices; drug therapy; percutaneous ventricular assist devices; cardiogenic shock; arrhythmias; ischemic heart disease

(This special issue belongs to the Section Cardiovascular Medicine)

Epilepsy and Cerebrovascular Disorders

edited by

Leonardo Roever

submission deadline 25 May 2026 | Viewed by 73 | Submission Open

Keywords: epilepsy; cerebrovascular disorders; stroke; post-stroke epilepsy; neuroinflammation; neuroimaging; electroenceph-alography; biomarkers; antiepileptic treatment; translational neuroscience

(This special issue belongs to the Section Clinical Neurology)

Advances in Kidney Transplantation: 2nd Edition

edited by Pedro Ruiz-Esteban, Domingo Hernández-Marrero and Verónica López-Jiménez

submission deadline 25 May 2026 | Viewed by 67 | Submission Open

Keywords: kidney transplant; acute rejection; biomarkers; artificial intelligence; post-transplant complications; graft survival

(This special issue belongs to the Section Nephrology & Urology)

Clinical Advances in Management of Urologic Diseases

edited by Francesco Pio Bizzarri and Calogero Casà

submission deadline 25 May 2026 | Viewed by 60 | Submission Open

Keywords: prostate cancer; bladder cancer; kidney cancer; uro-oncology; radiotherapy

(This special issue belongs to the Section Nephrology & Urology)

Advancements in Anterior Cruciate Ligament Injury: From Diagnosis to the Return-to-Sports: 2nd Edition

edited by Alexandre Hardy and Nicolas Bouguennec

submission deadline 28 May 2026 | 4 articles | Viewed by 3217 | Submission Open

Keywords: anterior cruciate ligament reconstruction (ACLR); timing of ACLR; ramp lesion; meniscal lesion; lateral extra-articular procedure

(This special issue belongs to the Section Sports Medicine)

Clinical Updates in Heart Transplantation

edited by

Giacomo Bianchi

submission deadline 28 May 2026 | 2 articles | Viewed by 1810 | Submission Open

Keywords: heart transplantation; ex vivo heart preservation; immunosuppression; xenotransplantation; pre-clinical models; dilated cardiomyopathy; amyloidosis; congenital heart disease

(This special issue belongs to the Section Cardiology)

Cerebrovascular Disease: Symptoms, Diagnosis and Current Treatment—Second Edition

edited by Alba Scerrati and Giorgio Mantovani

submission deadline 28 May 2026 | 2 articles | Viewed by 604 | Submission Open

Keywords: ischemic stroke; cerebral aneurysms; cerebral vascular malformation; cerebral venous disease; cerebral venous thrombosis

(This special issue belongs to the Section Clinical Neurology)

Innovations in Thoracic Surgery and Disease Management: Integrating Genomics, Technology, and Multidisciplinary Care

edited by

Marco Scarci

and

Savvas Lampridis

submission deadline 28 May 2026 | 1 articles | Viewed by 552 | Submission Open

Keywords: thoracic surgery; thoracic disease; genomic medicine; artificial intelligence; advanced imaging; multidisciplinary care; minimally invasive surgery; robotic surgery; precision medicine

(This special issue belongs to the Section Respiratory Medicine)

Novel Treatments for Vestibular Migraine

edited by

Teru Kamogashira

submission deadline 28 May 2026 | Viewed by 306 | Submission Open

Keywords: neuromodulation therapy; sympathetic nerve stimulation; CGRP-targeted therapy; dietary interventions; elimination diets; ketogenic diet; low-glycemic index diet; nutritional supplements; pathophysiology of vestibular migraine; clinical adoption of VM therapies

(This special issue belongs to the Section Otolaryngology)

Challenges in the Diagnosis and Treatment of Glaucoma

edited by

Abdelaziz Abdelaal

submission deadline 28 May 2026 | Viewed by 262 | Submission Open

Keywords: glaucoma diagnosis; glaucoma progression; glaucoma biomarkers; intraocular pressure (IOP) management; corneal hysteresis; machine learning in glaucoma detection; neuroprotection in glaucoma; surgery and laser therapy

(This special issue belongs to the Section Ophthalmology)

Spine Surgery Innovations: Treatments and Technologies

edited by

Marco D. Burkhard

and Tomoyuki Asada

submission deadline 29 May 2026 | Viewed by 437 | Submission Open

Keywords: AI; robotics; navigation; muscle preservation; minimally invasive surgery; motion preservation; alignment targets; implant materials; bone growth factors; custom-made implants

(This special issue belongs to the Section Orthopedics)

Pediatric Hearing Loss: Advances in Early Detection, Intervention and Family-Centered Care

edited by

Daniel Holzinger

and

Johannes Hofer

submission deadline 30 May 2026 | Viewed by 85 | Submission Open

Keywords: pediatric hearing loss; early intervention; early identification of language and communication disorders; develop-mental language disorders; predictors of outcomes; newborn hearing screening; pediatric audiology

(This special issue belongs to the Section Otolaryngology)

Clinical Perspectives on Women’s Reproductive Health: Challenges and Management Strategies

edited by

Seok Kyo Seo

submission deadline 31 May 2026 | 8 articles | Viewed by 17880 | Submission Open

Keywords: endometriosis; ovarian endometrioma; polycystic ovary syndrome; reproductive health; cervical; postmenopausal women; hormone replacement therapy; sarcopenia

(This special issue belongs to the Section Obstetrics & Gynecology)

Understanding Syncope: Multidisciplinary Approaches to Diagnosis and Management

edited by

Isabel Rocha

and Sérgio Laranjo

submission deadline 31 May 2026 | 4 articles | Viewed by 5589 | Submission Open

Keywords: syncope; diagnostic strategies; prognostication; treatment options; quality of life; wearable devices; artificial intelligence; autonomic dysfunction; orthostatic hypotension; POTS (postural orthostatic tachycardia syndrome)

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Updates on Prosthodontics

edited by

Rubén Agustín Panadero

and Carla Fons-Badal

submission deadline 31 May 2026 | 3 articles | Viewed by 3291 | Submission Open

Keywords: dental prosthesis; dental implants; gingival aesthetics; gingival treatment; dental aesthetics; dental ceramics; BOPT; surgical periodontal treatment

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Cardiovascular Magnetic Resonance Imaging: Precise Diagnosis and Therapeutic Guidance

edited by Radu Andy Sascau and

Carina Gabriela Ureche

submission deadline 31 May 2026 | 2 articles | Viewed by 1669 | Submission Open

Keywords: cardiac magnetic resonance; cardiomyopathy; tissue characterization; stress perfusion; 4D flow; heart failure; ischemic heart disease; multi-modality imaging; valvular heart disease; T1 mapping; T2 mapping; myocarditis

(This special issue belongs to the Section Cardiovascular Medicine)

Advances in Male Infertility: Diagnosis, Management and ART Integration

edited by Despoina Mavrogianni and Sofoklis Stavros

submission deadline 31 May 2026 | Viewed by 1240 | Submission Open

Keywords: male infertility; assisted reproductive technologies (ART); intracytoplasmic sperm injection (ICSI); genetic testing; hormonal profiling; seminal biomarkers; sperm retrieval techniques; sperm selection; stem cell therapy; gene editing; reproductive endo-crinology; early pregnancy; implantation failure; recurrent miscarriage

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Early Prevention and Diagnosis of Atherosclerosis: From Clinical Progression to Patient Management

edited by

Anna Kabłak-Ziembicka

submission deadline 31 May 2026 | 1 articles | Viewed by 806 | Submission Open

Keywords: atherosclerosis; atherothrombotic molecular pathways; cardiovascular risk; monitoring of goals; pharmacological and non-pharmacological prevention; carotid and peripheral interventions

(This special issue belongs to the Section Cardiovascular Medicine)

New Insights into Hepato-Biliary Diseases: Translating Science into Practice

edited by

Elisa Ceccherini

and

Antonella Cecchettini

submission deadline 31 May 2026 | Viewed by 344 | Submission Open

Keywords: hepato-biliary diseases; biomarkers; drug discovery; liver organoids and microfluidics; pathogenesis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Personalized Management of Abdominal Surgery and Complications

edited by Ioannis Mantzoros and

Orestis Ioannidis

submission deadline 31 May 2026 | Viewed by 128 | Submission Open

Keywords: personalized medicine; abdominal surgery; complications; emergency; innovative surgery

(This special issue belongs to the Section General Surgery)

Clinical Advances and Contemporary Applications of Echocardiography

edited by

Attila Nemes

submission deadline 31 May 2026 | Viewed by 97 | Submission Open

Keywords: echocardiography; speckle-tracking; three-dimensional; Doppler; cardiac; valve; vasculature

(This special issue belongs to the Section Cardiovascular Medicine)

Current Advances and Future Challenges in Heart Transplantation

edited by

Norihide Fukushima

submission deadline 31 May 2026 | Viewed by 82 | Submission Open

Keywords: heart transplantation; indication; surgical techniques; preoperative care; immunosuppressive regimens; mechanical circulatory support; donor assessment and management; cardiac donation after circulatory death; ex vivo machine perfusion; normothermic regional perfusion; cardiac xenotransplantation

(This special issue belongs to the Section Cardiology)

Applications of Artificial Intelligence (AI) in Surgery

edited by

Syed Ali Haider

and

Antonio Jorge Forte

submission deadline 31 May 2026 | Viewed by 68 | Submission Open

Keywords: artificial intelligence; machine learning; surgical robotics; computer vision; predictive analytics; surgical decision support; perioperative care; surgical outcomes; digital surgery

(This special issue belongs to the Section General Surgery)

Advances in the Management of Cancer Pain

edited by Wojciech Leppert

submission deadline 31 May 2026 | Viewed by 56 | Submission Open

Keywords: analgesia; analgesics; cancer patients; chronic pain; pain in cancer patients; pain assessment; non-opioids; opioid analgesics; adjuvant analgesics; non-pharmacology methods of pain management

(This special issue belongs to the Section Epidemiology & Public Health)

Aortic Surgery—Back to the Roots and Looking to the Future

edited by Ezin Deniz and

Aron-Frederik Popov

submission deadline 31 May 2026 | Viewed by 18 | Submission Open

Keywords: aortic surgery; hybrid and endovascular innovations; perioperative management; cerebral and organ protection; biomaterials; translational cardiovascular research; imaging in aortic disease; long-term outcomes; cardiovascular surgery

(This special issue belongs to the Section Cardiovascular Medicine)

Diagnosis and Treatment of Pediatric Endocrine Disorders—Focus on Rare Conditions

edited by Sophia Sakka

submission deadline 1 Jun 2026 | Viewed by 1146 | Submission Open

Keywords: pediatric endocrinology; diabetes mellitus in children; bone metabolism disorders; clinical diagnosis; therapeutic strategies; skeletal dysplasias; rare endocrine conditions; pediatric type 1 diabetes; rickets management; genetic conditions; pediatric hormone therapy; achondroplasia

(This special issue belongs to the Section Endocrinology & Metabolism)

Displaying special issue 1051-1100 on page 22 of 31.

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