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Clinical Perspectives on Women’s Reproductive Health: Challenges and Management Strategies
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Clinical Perspectives on Women’s Reproductive Health: Challenges and Management Strategies

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 30 December 2025 | Viewed by 508

Special Issue Editor

Prof. Dr. Seok Kyo Seo

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea
Interests: endometriosis; ovarian endometrioma; fertilization; polycystic ovary syndrome; reproductive health; prepubertal and postpubertal; ovarian; cervical; postmenopausal women; hormone replacement therapy

Special Issue Information

Dear Colleagues,

In recent years, the prevalence of gynecological conditions such as endometriosis and polycystic ovary syndrome (PCOS) has shown a marked increase among women of reproductive age. These chronic disorders significantly impact reproductive function and long-term metabolic health. Recent advancements in clinical and translational research have led to the development of fertility-preserving strategies in endometriosis, including refined surgical techniques and tailored hormonal therapies. Similarly, evolving insights into the heterogeneity of PCOS have contributed to improved diagnostic algorithms and individualized treatment approaches.

In parallel, increasing attention is being given to reproductive aging and the health of postmenopausal women, particularly regarding the impact of estrogen deficiency on sarcopenia and overall metabolic resilience. Evidence supporting the role of hormone replacement therapy (HRT) in maintaining musculoskeletal health continues to grow, warranting further exploration through well-designed clinical studies.

This Special Issue aims to highlight current challenges and evolving perspectives in women’s reproductive health, with a focus on the increasing prevalence of endometriosis and PCOS, recent advances in therapeutic approaches, and the implications of hormonal changes in postmenopausal health, in light of the most up-to-date clinical evidence.

Prof. Dr. Seok Kyo Seo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endometriosis
  • ovarian endometrioma
  • polycystic ovary syndrome
  • reproductive health
  • cervical
  • postmenopausal women
  • hormone replacement therapy
  • sarcopenia

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Published Papers (2 papers)

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Research

12 pages, 733 KiB  
Article
Effects of Endometriosis on Anti-Müllerian Hormone
by Yun Soo Chung, Euna Choi, Jin Kyung Baek, Heeyon Kim and Bo Hyon Yun
J. Clin. Med. 2025, 14(13), 4495; https://doi.org/10.3390/jcm14134495 - 25 Jun 2025
Viewed by 94
Abstract
Background/Objectives: As the population of women with endometriosis increases, approximately 10% of those of reproductive age experience symptoms such as pelvic pain, painful menstruation, and infertility. Individuals with endometriosis usually undergo multiple surgeries due to the high recurrence rate of the condition. [...] Read more.
Background/Objectives: As the population of women with endometriosis increases, approximately 10% of those of reproductive age experience symptoms such as pelvic pain, painful menstruation, and infertility. Individuals with endometriosis usually undergo multiple surgeries due to the high recurrence rate of the condition. However, ovarian surgery tends to reduce the ovarian reserve, presenting a dilemma when deciding whether to recommend surgery or medical treatment for women of reproductive age. The impact of endometriomas on the residual volume of ovarian tissue remains controversial, and it is unclear whether endometriosis itself or endometriomas are the primary problem. In this study, we aimed to investigate whether women with endometriosis have lower levels of anti-Müllerian hormone than women with healthy ovaries before treatment initiation. Methods: A total of 298 participants enrolled in the endometriosis cohort at Severance Hospital, Korea, from 1 October 2020 to 1 July 2024 were included in this study. Of these, 63 participants were from a retrospective study, and 235 were from a prospective study. Due to the use of different assay methods between the reference values and anti-Müllerian hormone measurements from Severance Hospital, a correction was applied using the regression equation. The mean anti-Müllerian hormone levels for individuals with endometriosis were corrected with the regression equation and compared to those of the reference group for each age group using a one-sample t-test. Results: Anti-Müllerian hormone levels decreased with age in the endometriosis group. When comparing mean anti-Müllerian hormone concentrations between the endometriosis group and reference values, among 168 participants aged 20–31 years, the corrected mean anti-Müllerian hormone concentration was 5.96 ± 3.22 ng/mL, higher than the reference value of 4.94 ± 0.17 ng/mL (p < 0.01). Among 31 participants aged 35–37 years, the corrected average anti-Müllerian hormone value was 4.33 ± 3.06 ng/mL, compared to the reference anti-Müllerian hormone level of 3.22 ± 0.15 ng/mL (p = 0.05). There were no significant differences in corrected anti-Müllerian hormone levels between the 32–34-, 38–40-, 41–43-, and ≥44 years age groups. Conclusions: Patients with endometriosis, especially those aged 20–31 years, tended to have higher anti-Müllerian hormone levels than did individuals with healthy ovaries. In other age groups, there were no differences. Given that these levels do not differ significantly across age groups, it is difficult to conclude that patients with endometriosis have a reduced ovarian reserve. Full article
(This article belongs to the Special Issue Clinical Perspectives on Women’s Reproductive Health: Challenges and Management Strategies)
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12 pages, 4200 KiB  
Article
The Development of an Ultrasound-Based Scoring System for the Prediction of Interstitial Pregnancy
by Yun Ji Jung, Hyun-Soo Zhang, Eun Jin Lee, Hayan Kwon, Ja-Young Kwon, Young-Han Kim and JoonHo Lee
J. Clin. Med. 2025, 14(12), 4238; https://doi.org/10.3390/jcm14124238 - 14 Jun 2025
Viewed by 269
Abstract
Background/Objectives: Diagnosing interstitial pregnancy (IP) using ultrasonography can be challenging, as it is often mistaken for eccentrically located intrauterine pregnancy (IUP). In this retrospective cohort study, we aimed to develop a predictive scoring model using multiple clinical factors to enhance the diagnosis [...] Read more.
Background/Objectives: Diagnosing interstitial pregnancy (IP) using ultrasonography can be challenging, as it is often mistaken for eccentrically located intrauterine pregnancy (IUP). In this retrospective cohort study, we aimed to develop a predictive scoring model using multiple clinical factors to enhance the diagnosis of IP and facilitate timely interventions in suspected cases. Methods: We enrolled 63 pregnant women with a diagnosis of suspected IP who visited a single tertiary center between January 2006 and December 2023. Data on the clinical risk factors, symptoms, laboratory test results, and ultrasound findings were analyzed. A statistical predictive score was developed using logistic regression analysis with feature selection based on the least absolute shrinkage and selection operator to optimize the predictive accuracy and clinical applicability. Results: From a total of 12 factors, a scoring model was constructed from the three most prominent factors—ultrasound findings showing no surrounding endometrium, myometrial thinning of less than 5 mm, and vaginal bleeding—all of which demonstrated high feature importance. This predictive score identified IP with a negative predictive value of 0.950 in the low-risk group and a positive predictive value of 1.000 in the high-risk group, whereas the overall area under the curve was 0.998 (95% confidence interval, 0.992–1.000). Conclusions: The statistically derived predictive model––ultrasound showing no surrounding endometrium and myometrial thinning < 5 mm combined with vaginal bleeding––demonstrated high accuracy and practical applicability for IP diagnosis, providing a robust tool to enhance clinical decision-making and optimize routine management strategies for IP. Full article
(This article belongs to the Special Issue Clinical Perspectives on Women’s Reproductive Health: Challenges and Management Strategies)
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