Clinical Prediction, Diagnosis, and Treatment of Ovarian Cancer and Other Gynecologic Tumors
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".
Deadline for manuscript submissions: 15 December 2025 | Viewed by 68
Special Issue Editors
Interests: gynecologic cancer; breast cancer; translational research; clinical trials
Interests: breast cancer; hereditary cancer; biomarkers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Ovarian cancer remains a diagnostic and therapeutic challenge in the area of gynecologic oncology. The majority of cases are high-grade tumors, usually diagnosed at an advanced stage. These patients undergo either primary or interval debulking, targeting ideally to radical surgery.
The induction of PARP inhibitors in the management of advanced platinum-responsive disease has improved outcomes in first- and second-line treatment; however, a number of patients fail to remain in PARP maintenance longer than a few months, while some present with de novo resistance.
Patients who fail to achieve a complete remission at the end of the initial line of therapy are at risk of early progression and poor response to further treatments.
Considering these, ovarian cancer leaves ample space for research, both basic and clinical.
More or less, this stands for the rest of the gynecological malignancies that have long been poorly understood and managed. Cervical and endometrial cancer are entering a new era where immunotherapy holds a growing part, together with upcoming novel agents.
In this Special Issue we welcome your work in original research, reviews, meta-analyses, case reports, or short letters in all chapters of gynecologic cancer management, including screening, diagnosis, and treatment.
Dr. Eleni T. Timotheadou
Dr. Emmanouil Saloustros
Guest Editors
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Keywords
- ovarian
- endometrial
- cervical
- chemotherapy
- immunotherapy
- primary debulking surgery
- interval debulking
- fertility-sparing surgery
- PARP inhibitors
- radiotherapy
- HIPEC
- sex cord tumors
- dysgerminoma
- leiomyosarcoma
- liquid biopsies
- circulating tumor cells
- ctDNA
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