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JCM
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Cardiovascular Magnetic Resonance Imaging: Precise Diagnosis and Therapeutic Guidance
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Cardiovascular Magnetic Resonance Imaging: Precise Diagnosis and Therapeutic Guidance

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 30 December 2025 | Viewed by 1475

Special Issue Editors

Dr. Radu Andy Sascau

E-Mail Website
Guest Editor
1. Department of Internal Medicine, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 University Street, 700115 Iasi, Romania
2. Prof. Dr. George I.M. Georgescu Institute of Cardiovascular Diseases, Carol I Boulevard, No. 50, 700503 Iasi, Romania
Interests: coronary artery disease; echocardiography; cardiology
Dr. Carina Gabriela Ureche

E-Mail Website
Guest Editor
1. Department of Internal Medicine, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 University Street, 700115 Iasi, Romania
2. Prof. Dr. George I.M. Georgescu Institute of Cardiovascular Diseases, Carol I Boulevard, No. 50, 700503 Iasi, Romania
Interests: clinical cardiology; advanced cardiac imaging by magnetic resonance; cardiac imaging in advanced chronic kidney disease; cardiomyopathy; chronic heart failure

Special Issue Information

Dear Colleagues,

Cardiovascular magnetic resonance (CMR) imaging has become a cornerstone of contemporary cardiology, offering unparalleled insights into cardiac anatomy and function, tissue characterization, and blood flow—without the use of ionizing radiation. From ischemic heart disease to cardiomyopathies, myocarditis, and congenital heart disease, CMR enables precise diagnosis, risk stratification, and treatment planning. Its ability to provide high-resolution images and tissue-specific information makes it a vital tool in both clinical and research settings.

Recent advances such as parametric mapping, strain imaging, and stress perfusion have further expanded the clinical applications of CMR. As the field continues to evolve, CMR will play a critical role in understanding complex cardiovascular conditions and guiding precision medicine.

In light of its growing importance, we are pleased to announce a Special Issue of JCM dedicated to CMR—“Cardiovascular Magnetic Resonance Imaging: Precise Diagnosis and Therapeutic Guidance”. We invite researchers, clinicians, and imaging specialists to contribute original research articles and comprehensive reviews that explore the diagnostic, prognostic, and therapeutic value of CMR. Submissions may include, but are not limited to, advances in imaging techniques, clinical applications, AI integration in image analysis, and novel uses for CMR in rare cardiac conditions.

We look forward to your contributions that will enrich the field and inspire ongoing collaboration across disciplines.

Dr. Radu Andy Sascau
Dr. Carina Gabriela Ureche
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiac magnetic resonance
  • cardiomyopathy
  • tissue characterization
  • stress perfusion
  • 4D flow
  • heart failure
  • ischemic heart disease
  • multi-modality imaging
  • valvular heart disease
  • T1 mapping
  • T2 mapping
  • myocarditis

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Published Papers (2 papers)

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Research

13 pages, 1867 KB  
Article
Coronary Artery Disease in Cardiac Amyloidosis: Prevalence, Clinical Relevance, and Cardiac Magnetic Resonance Imaging Features
by Carolina Donà, Renè Rettl, Christina Binder-Rodriguez, Daniel Dalos, Christina Kronberger, Michael Poledniczek, Robin Willixhofer, Nikita Ermolaev, Luciana Camuz-Ligios, Hermine Agis, Matthias Koschutnik, Dietrich Beitzke, Christian Loewe, Christian Nitsche, Christian Hengstenberg, Roza Badr Eslam, Johannes Kastner, Jutta Bergler-Klein, Andreas Anselm Kammerlander and Franz Duca
J. Clin. Med. 2025, 14(24), 8802; https://doi.org/10.3390/jcm14248802 - 12 Dec 2025
Viewed by 185
Abstract
Background/Objectives: Cardiac amyloidosis (CA) as well as coronary artery disease (CAD) are both highly prevalent among the elderly. However, both the prevalence and risk factors associated with significant CAD among patients with CA, as well as potential outcome disparities, remain mainly unexplored. [...] Read more.
Background/Objectives: Cardiac amyloidosis (CA) as well as coronary artery disease (CAD) are both highly prevalent among the elderly. However, both the prevalence and risk factors associated with significant CAD among patients with CA, as well as potential outcome disparities, remain mainly unexplored. This study aimed to show the prevalence of CAD in patients with CA, as well as to assess outcomes and differences in late gadolinium enhancement (LGE) in comparison to patients with lone CA. Methods: We retrospectively assessed CA patients who underwent CAD assessment between 2013 and 2023. The primary endpoint was all-cause death. A subgroup underwent cardiac magnetic resonance imaging (CMR) with LGE assessment. Results: Of 255 consecutive patients with CA, 81 patients had significant CAD. Differences could be found with respect to age, sex, arterial hypertension, and hyperlipidemia. Significant differences in CMR features could only be found with respect to indexed left-ventricular end-diastolic volume, as well as left-ventricular mass. CAD-specific LGE was present only in 17.7% of patients with CAD, while most patients showed typical amyloid LGE, making a viability diagnosis difficult via CMR, especially in patients with end-stage CA. No differences in outcomes could be observed according to the prevalence of CAD. Conclusions: Concomitant obstructive CAD is highly prevalent among patients with CA. However, the presence of CAD does not influence patient outcomes. Furthermore, our data suggests that CAD viability testing by CMR might be complicated in patients with concomitant CA due to the high prevalence of amyloid-specific LGE. Full article
(This article belongs to the Special Issue Cardiovascular Magnetic Resonance Imaging: Precise Diagnosis and Therapeutic Guidance)
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14 pages, 914 KB  
Article
Standardized Myocardial T1 and T2 Relaxation Times: Defining Age- and Comorbidity-Adjusted Reference Values for Improved CMR-Based Tissue Characterization
by Mukaram Rana, Vitali Koch, Simon Martin, Thomas Vogl, Marco M. Ochs, David M. Leistner and Sebastian M. Haberkorn
J. Clin. Med. 2025, 14(17), 6198; https://doi.org/10.3390/jcm14176198 - 2 Sep 2025
Viewed by 1059
Abstract
Background: This study aims to establish standardized reference values for myocardial T1 and T2 relaxation times in a clinically and imaging-defined real-world patient cohort, evaluating their variability in relation to age, sex, and comorbidities. By identifying key physiological and pathological influences, this investigation [...] Read more.
Background: This study aims to establish standardized reference values for myocardial T1 and T2 relaxation times in a clinically and imaging-defined real-world patient cohort, evaluating their variability in relation to age, sex, and comorbidities. By identifying key physiological and pathological influences, this investigation seeks to enhance CMR-based myocardial mapping for improved differentiation between normal and pathological myocardial conditions. Methods: This retrospective observational study analyzed T1 and T2 relaxation times using CMR at 1.5 Tesla in a cohort of 491 subjects. T1 and T2 times were measured using MOLLI and GRASE sequences, and statistical analyses assessed intra- and interindividual variations, including the influence of age, sex, and comorbidities, to establish reference values and improve myocardial tissue characterization. Results: T1 and T2 relaxation times were analyzed in 291 and 200 participants, respectively. The mean global T1 time was 1004.7 ± 49.8 ms, with no significant differences between age groups (p = 0.81) or sexes (p = 0.58). However, atrial fibrillation (AF) and mitral regurgitation (MR) were associated with significantly prolonged T1 times (p < 0.05). The mean global T2 time was 67.4 ± 8.6 ms, with age-related prolongation (p < 0.05), but no sex differences (p = 0.46). Comorbidities did not significantly influence T2 times, except for NYHA Class III–IV patients, who exhibited prolonged T2 values (p < 0.05). Conclusions: Standardized T1 and T2 reference values are essential to improve diagnostic accuracy and risk stratification in CMR-based myocardial tissue characterization. Future research should focus on multicenter validation, AI-driven analysis, and the development of age- and comorbidity-adjusted normative databases to enhance individualized cardiovascular care. Full article
(This article belongs to the Special Issue Cardiovascular Magnetic Resonance Imaging: Precise Diagnosis and Therapeutic Guidance)
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