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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advancements in Individualized Plastic and Reconstructive Surgery: Second Edition
edited by , Peter Niclas Broer and Denis C. Ehrl
submission deadline 25 Jan 2026 | 1 articles | Viewed by 1334 | Submission Open
Keywords: patient-specific reconstructive procedures; microsurgical precision techniques; autologous tissue transplantation; digital imaging and customization; biomaterials in reconstructive surgery; tissue engineering for plastic reconstruction; flap surgery innovations; personalized cleft surgery; personalized aesthetic surgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Ocular Surface Disease: Epidemiology, Diagnosis and Management submission deadline 25 Jan 2026 | Viewed by 859 | Submission Open
Keywords: dry eye disease; risk factors; ocular surface disease; inflammatory biomarkers; anterior segment imaging; emerging therapies
(This special issue belongs to the Section Ophthalmology)
Machine Learning and Artificial Intelligence in Neurosurgery
edited by Jan Oliver Neumann and
submission deadline 25 Jan 2026 | Viewed by 480 | Submission Open
Keywords: artificial intelligence; neurosurgery; neuro-oncology; spinal neurosurgery; neuro-ICU; stereotactic neurosurgery; pre-operative planning
(This special issue belongs to the Section Clinical Neurology)
Shoulder and Elbow Surgery: Clinical Updates and Perspectives
edited by Taku Hatta, Akihiko Hasegawa and Takuma Yuri
submission deadline 25 Jan 2026 | Viewed by 336 | Submission Open
Keywords: rotator cuff injuries; shoulder arthroplasty; elbow surgery; shoulder surgery; shoulder and elbow disease; arthroscopic surgery; orthopedic surgery
(This special issue belongs to the Section Orthopedics)
Kidney Transplantation: Challenges, Advances and Lessons Learnt submission deadline 25 Jan 2026 | Viewed by 333 | Submission Open
Keywords: kidney transplantation; nephrology; transplant medicine; patient selection criteria; immunosuppressive treatment; long-term outcomes; graft survival; complication; multi-organ transplant consideration; innovation
(This special issue belongs to the Section Nephrology & Urology)
Clinical Advances in Hysteroscopic Technology for Gynecological Diseases
edited by Aya Mohr-Sasson and Raanan Meyer
submission deadline 25 Jan 2026 | Viewed by 275 | Submission Open
Keywords: diagnostic hysteroscopy; operative hysteroscopy; uterine sampling; uterine polyp; submucosal fibroid; hysteroscopic dilatation and curettage; hysteroscopic niche repair
(This special issue belongs to the Section Obstetrics & Gynecology)
Recent Clinical Advances in Reconstructive Urology and Prosthetic Surgery
edited by Elisa Berdondini and
submission deadline 25 Jan 2026 | Viewed by 142 | Submission Open
Keywords: reconstructive urology; penile prosthesis; artificial urinary sphincter; urethral stricture; reconstructive surgery; minimally invasive procedures
(This special issue belongs to the Section Nephrology & Urology)
Further Advances in Electrocardiography, Cardiac Arrhythmias, and Arrhythmogenic Disorders: 2nd Edition submission deadline 25 Jan 2026 | Viewed by 121 | Submission Open
Keywords: electrocardiography; cardiac arrhythmias; genetics; cardiac pacing; implantable cardioverter defibrillators; cardiac resynchronization therapy; magnetic resonance imaging; catheter ablation; arrhythmogenic disorders; channelopathy; cardiomyopathy
(This special issue belongs to the Section Cardiology)
Clinical Updates in the Use of Artificial Intelligence for Radiology
edited by
submission deadline 25 Jan 2026 | Viewed by 115 | Submission Open
Keywords: deep learning; denoising; calculator; nn-UNet; automation; outcomes; quality control; DICE; Halsdorrf; Jaccard
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Otologic Disorders and Hearing Impairment: From Diagnosis to Rehabilitation
edited by Andrea Albera and Andrea Canale
submission deadline 25 Jan 2026 | Viewed by 100 | Submission Open
Keywords: otology; hearing loss; cochlear implants; middle ear surgery; otitis media; otosclerosis; auditory rehabilitation; ves-tibular disorders; hearing aid; bone-conduction implants
(This special issue belongs to the Section Otolaryngology)
Novel Developments on Diagnosis and Treatment of Atrial Fibrillation
edited by and Mihaela-Viviana Ivan
submission deadline 26 Jan 2026 | 4 articles | Viewed by 3950 | Submission Open
Keywords: atrial fibrillation; supraventricular arrhythmia; cardiovascular risk; oxidative stress; inflammation
(This special issue belongs to the Section Cardiovascular Medicine)
New Insights into Peritoneal Dialysis and Hemodialysis: 2nd Edition submission deadline 26 Jan 2026 | 1 articles | Viewed by 2155 | Submission Open
Keywords: hemodialysis; peritoneal dialysis; end-stage renal disease; kidney replacement therapy (KRT); pathophysiology; di-alysis membranes; dialysis preparation; dialysis modality; cardiovascular events; vascular access; PD-related perito-nitis; unfavorable adverse effects; complications; challenges; inflammation
(This special issue belongs to the Section Nephrology & Urology)
Osteoporotic Fractures of the Pelvis, Hip and Femur: Current Challenges and New Perspectives (2nd Edition)
edited by Andreas Hoch
submission deadline 26 Jan 2026 | Viewed by 93 | Submission Open
Keywords: osteoporosis; fracture management; pelvic fractures; periprosthetic fractures; proximal femoral fractures; non-operative therapies
(This special issue belongs to the Section Orthopedics)
Diagnosis and Treatment for Bone Tumor
edited by Antonio Ziranu and Luigi Cianni
submission deadline 27 Jan 2026 | 4 articles | Viewed by 4081 | Submission Open
Keywords: bone tumor; oncology; osteosarcoma; chondrosarcoma; megaprosthesis; bone resection; chemotherapy; radiotherapy; sarcoma; custom-made
(This special issue belongs to the Section Orthopedics)
Challenges in Diagnosis and Treatment of Infertility—2nd Edition
edited by Konstantinos A. Zikopoulos
submission deadline 27 Jan 2026 | 1 articles | Viewed by 3527 | Submission Open
Keywords: fertility; regeneration; age-related infertility; preimplantation diagnosis; precision assessment; individualized fertility needs; clinical diagnosis; in vitro fertilization
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Clinical Advances in Scleral Lenses: New Insights in Lens Fitting and Customization
edited by and
submission deadline 27 Jan 2026 | Viewed by 406 | Submission Open
Keywords: scleral lenses; scleral lens customization; higher-order aberrations; scleral lens optics; corneoscleral profilometry; keratoconus; ocular surface diseases; dry eye; wavefront-guided correction
(This special issue belongs to the Section Ophthalmology)
Heart Valve Surgery: Recent Trends and Future Perspective
edited by Per Nils J.F. Wierup, Johan Sjögren and Nina Hakacova
submission deadline 27 Jan 2026 | Viewed by 122 | Submission Open
Keywords: heart valve; diagnostics; surgery; echocardiography; computer simulation; prediction models
(This special issue belongs to the Section Cardiology)
Inflammatory Bowel Disease: Pathogenesis and Management Strategies
edited by
submission deadline 28 Jan 2026 | 2 articles | Viewed by 1370 | Submission Open
Keywords: inflammatory bowel diseases; ulcerative colitis; Crohn’ s disease; biomarkers; risk factors; pharmacology; advanced therapy; endoscopic evaluation and procedures; extraintestinal manifestations; IBD-associated neoplasm
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Hepatitis: Prevention, Treatment, and Global Health Impact submission deadline 28 Jan 2026 | 1 articles | Viewed by 924 | Submission Open
Keywords: hepatitis B; hepatitis C; liver disease; direct-acting antivirals (DAAs); global health; public health policy; viral hepa-titis elimination; health disparities; cirrhosis; vaccination programs
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Current Evidence and Future Directions in Clostridioides difficile Infection Epidemiology, Diagnosis and Treatment submission deadline 28 Jan 2026 | Viewed by 126 | Submission Open
Keywords: Clostridioides difficile infection; infection control; contact isolation; community-acquired CDI; CDI recurrence; recurrence prevention; rCDI; host and microbiota interaction; antimicrobial treat-ment; microbiota transplant; underdiagnosis
(This special issue belongs to the Section Infectious Diseases)
Acute Myocardial Infarction: Clinical Advances in Prognostic Stratification, Diagnosis, and Treatment submission deadline 29 Jan 2026 | 5 articles | Viewed by 7914 | Submission Open
Keywords: acute myocardial infarction (AMI); atherosclerosis; ST segment elevation myocardial infarction (STEMI); non-ST elevation myocardial infarction (NSTEMI); acute coronary syndrome (ACS); prognosis; coronary CT angiography (CCTA); cardiac magnetic resonance (CMR); reperfusion therapy; antiplatelet therapy
(This special issue belongs to the Section Cardiology)
New Advances in Cardiorenal Syndrome: 2nd Edition submission deadline 30 Jan 2026 | 5 articles | Viewed by 15402 | Submission Open
Keywords: cardiorenal syndrome; outcome; hyperkalemia; acute kidney injury; chronic kidney disease; chronic heart failure
(This special issue belongs to the Section Cardiology)
Cerebral Palsy: Clinical Rehabilitation and Treatment
edited by Joav Merrick and
submission deadline 30 Jan 2026 | 7 articles | Viewed by 12594 | Submission Open
Keywords: cerebral palsy; physiotherapy; occupational therapy; orthopedic management; medical management; rehabilitation approaches
(This special issue belongs to the Section Clinical Neurology)
Advances and Perspectives in Cancer Diagnostics and Treatment
edited by Alexandru E. Eniu, and
submission deadline 30 Jan 2026 | 5 articles | Viewed by 4166 | Submission Open
Keywords: solid tumors; new advances; diagnostics and treatment; clinical– pathological; genetic factors; AI; RWD; radiotherapy; biomarkers; prevention in cancer care; target therapy; immunotherapy
(This special issue belongs to the Section Oncology)
The Current Status and Future Directions of Pancreatoduodenectomy and Pancreatectomy
edited by , and Somaiah Aroori
submission deadline 30 Jan 2026 | 2 articles | Viewed by 2737 | Submission Open
Keywords: pancreatic resection types; techniques and modifications; anastomotic techniques; open resection; minimally invasive surgery; laparoscopic resection; robotic resection; hybrid resection techniques; pancreatic resection post neoadjuvant treatment; lymphadenectomy; vascular resections; organ-sparing procedures; radicality; indications; complications
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Updates in Bleeding and Thrombotic Disorders
edited by
submission deadline 30 Jan 2026 | 2 articles | Viewed by 1825 | Submission Open
Keywords: autoimmune-acquired coagulation deficiency; acquired hemophilia A; disseminated intravascular coagulation; thrombotic microangiopathy; venous thromboembolism; acute coronary syndrome; clot waveform analysis; thrombin generation test; thromboelastogram
(This special issue belongs to the Section Hematology)
Current Advances in General and Regional Anesthesia
edited by Eleni Laou, Eleana Garini and Giolanda Varvarousi
submission deadline 30 Jan 2026 | 2 articles | Viewed by 1813 | Submission Open
Keywords: anesthesiology; general anesthesia; regional anesthesia; pediatric anesthesia; perioperative medicine; surgery; postoperative outcome; monitoring; analgesia; safety
(This special issue belongs to the Section Anesthesiology)
Advances in Minimally Invasive Surgery: Transformative Technologies, Techniques and Trends
edited by Michail Pitiakoudis
submission deadline 30 Jan 2026 | 2 articles | Viewed by 1389 | Submission Open
Keywords: minimally invasive surgery; laparoscopic surgery; robotic surgery; surgical innovation; hernia repair; colorectal surgery; gastrointestinal surgery; hepatopancreatobiliary surgery; surgical simulation; virtual reality; augmented reality; artificial intelligence; surgical training; patient outcomes; surgical oncology
(This special issue belongs to the Section General Surgery)
The Optimal Hybrid Revascularization Approach for Multilevel Peripheral Arterial Disease
edited by
submission deadline 30 Jan 2026 | 1 articles | Viewed by 1178 | Submission Open
Keywords: peripheral arterial disease; revascularization; endovascular procedure; endarterectomy; limb salvage; patency; hybrid procedures; lower extremity; stents; angioplasty
(This special issue belongs to the Section Vascular Medicine)
Insights on Cancer Diagnosis, Treatment and Side Effects Management submission deadline 30 Jan 2026 | 1 articles | Viewed by 1116 | Submission Open
Keywords: cancer diagnosis; cancer treatment; side effects management; oncology; personalized medicine; supportive care
(This special issue belongs to the Section Oncology)
Clinical Outcomes in Bipolar and Depressive Disorders
edited by and Francesco Monaco
submission deadline 30 Jan 2026 | 1 articles | Viewed by 468 | Submission Open
Keywords: mood disorders; clinical outcomes; treatment response; psychopathology; pathophysiology
(This special issue belongs to the Section Mental Health)
Mind–Body Connection: The Impact of Mental Health on Physical Well-Being
edited by
submission deadline 30 Jan 2026 | Viewed by 296 | Submission Open
Keywords: mind– body connection; mental health; well-being; metabolic balance; immune system; chronic medical conditions; body perception; self-image; eating disorders; psychosomatic disorders; psychosomatic medicine; innovative thera-peutic approaches; mindfulness; mind-wandering; integrated healthcare
(This special issue belongs to the Section Mental Health)
Atrial Fibrillation and Heart Failure: Diagnostic and Therapeutic Challenges and Breakthroughs submission deadline 30 Jan 2026 | Viewed by 166 | Submission Open
Keywords: atrial fibrillation; heart failure; cardiac electrophysiology; ventricular remodelling; rhythm control; catheter abla-tion; neurohormonal activation; biomarkers; ischemia; integrated cardiovascular care
(This special issue belongs to the Section Cardiology)
Colorectal Cancer: Early Detection, Treatment Advances and Patient Outcomes
edited by , and Federica Giordano
submission deadline 30 Jan 2026 | Viewed by 163 | Submission Open
Keywords: colorectal cancer; early detection; prevention; innovation; screening; precision medicine; biomarkers; genetic profile
(This special issue belongs to the Section Oncology)
Causes and Advanced Treatments of Macular Edema submission deadline 31 Jan 2026 | 4 articles | Viewed by 7229 | Submission Open
Keywords: macular edema; laser photocoagulation; subthreshold laser; anti-VEGF; optical coherence tomography; fluorescein angiography; angio-OCT
(This special issue belongs to the Section Ophthalmology)
The Role of Biomarkers in Cardiovascular Diseases
edited by Giorgia Panichella
submission deadline 31 Jan 2026 | 5 articles | Viewed by 5287 | Submission Open
Keywords: biomarkers; cardiovascular diseases; heart failure; ischemic heart disease; cardiomyopathy; risk stratification; diagnosis; prognosis; inflammation
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Management, Diagnosis and Treatment of Thoracic Diseases: 2nd Edition submission deadline 31 Jan 2026 | 2 articles | Viewed by 4200 | Submission Open
Keywords: lung; thorax; pneumonia; chest; imaging; ultrasound
(This special issue belongs to the Section Respiratory Medicine)
Diagnosis and Treatment of Obstetrics and Gynecology Cancers
edited by
submission deadline 31 Jan 2026 | 3 articles | Viewed by 3841 | Submission Open
Keywords: gynecological cancers; endometrial cancer; ovarian cancer; cervical cancer; vulvar cancer; vaginal cancer; breast cancer; surgery; radio-therapy; systemic treatment; immunotherapy; sentinel lymph node biopsy; minimally invasive surgery; fertility preservation; gestational trophoblastic disease
(This special issue belongs to the Section Obstetrics & Gynecology)
Acute Coronary Syndromes: Clinical Advances in Diagnosis and Treatment
edited by Pierre Sabouret, and
submission deadline 31 Jan 2026 | 3 articles | Viewed by 2970 | Submission Open
Keywords: acute coronary syndromes; myocardial infarction; cardiac biomarkers; antiplatelet therapy; revascularization; precision medicine; risk stratification
(This special issue belongs to the Section Cardiology)
Thoracic Surgery: Updates and New Trends
edited by
submission deadline 31 Jan 2026 | 2 articles | Viewed by 1891 | Submission Open
Keywords: minimally invasive surgery; new technology; diagnosis; bronchoscopy; robotic system; artificial intelligence
(This special issue belongs to the Section Respiratory Medicine)
Revolutionizing Neurosurgery: Cutting-Edge Techniques and Innovations
edited by
submission deadline 31 Jan 2026 | 2 articles | Viewed by 1727 | Submission Open
Keywords: neuroendovascular surgery; neuroimaging; neurosurgery; neuroendoscopic surgery
(This special issue belongs to the Section Clinical Neurology)
Molecular Injection Therapy in Orthopedic and Musculoskeletal Disorders: Conservative Approaches and Innovative Treatments
edited by , Paolo Domenico Parchi and Andrea del Chiaro
submission deadline 31 Jan 2026 | 2 articles | Viewed by 1468 | Submission Open
Keywords: injection therapy; conservative approaches; medical devices; collagen; polyribonucleotide; plasma-rich platelets; hyaluronic acids; anti-inflammatory therapy; tendinitis; osteoarthritis; musculoskeletal disorder; pain reduction; regenerative medicine; new clinical approaches; physiotherapy; comparative studies: surgery vs. conservative approaches
(This special issue belongs to the Section Orthopedics)
Management of Ligaments and Tendons Injuries
edited by Vivek Kumar Morya
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1414 | Submission Open
Keywords: tendinopathy; ligaments; tendons; anterior cruciate ligament (ACL); rotator cuff
(This special issue belongs to the Section Orthopedics)
Pushing Boundaries in Cardiac Resynchronization Therapy: Clinical Innovations Transforming Heart Failure Management
edited by István Szokodi and
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1088 | Submission Open
Keywords: cardiac resynchronization therapy; heart failure; pacing strategies; patient selection; multi-point pacing; clinical innovations; nonresponders
(This special issue belongs to the Section Cardiology)
Diagnosis and Treatment of Aortic Dissection: Experts' Views
edited by Marja K Hedman and Annastiina Husso
submission deadline 31 Jan 2026 | 1 articles | Viewed by 770 | Submission Open
Keywords: aortic diseases; aortic type A dissection; aortic growth rate; aortic length; aortic imaging
(This special issue belongs to the Section Cardiology)
Clinical Challenges and Advances in Periodontology and Oral Surgery: 2nd Edition
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 734 | Submission Open
Keywords: oral surgery; third molar; periodontitis; antibiotics; infection; pain; research; advances; complications; dental implants; bone regeneration; maxillofacial surgery
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Trauma Surgery: Strategies, Challenges and Vision of the Future
edited by and Yaniv S. Warschawski
submission deadline 31 Jan 2026 | 1 articles | Viewed by 627 | Submission Open
Keywords: orthopaedic surgery; fractures; injuries; upper limb; trauma
(This special issue belongs to the Section Clinical Research Methods)
Innovations in Spine Care: Advancing Clinical Solutions and Emerging Technologies
edited by , , Gianluca Vadalà and Vincenzo Denaro
submission deadline 31 Jan 2026 | 1 articles | Viewed by 588 | Submission Open
Keywords: artificial intelligence; AI; minimally invasive spine surgery; MIS; endoscopic spine surgery; intervertebral disc regeneration; precision medicine; spine care; spine fusion; osteobiologics
(This special issue belongs to the Section Orthopedics)
Cardiothoracic and Vascular Anesthesia—Clinical Management and Challenges
edited by Marko Zdravković and
submission deadline 31 Jan 2026 | 1 articles | Viewed by 573 | Submission Open
Keywords: cardiac anesthesia; thoracic anesthesia; vascular anesthesia; innovation; perioperative medicine; healthcare; outcomes; challenges
(This special issue belongs to the Section Anesthesiology)
Clinical Updates on Dyslipidemia
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 528 | Submission Open
Keywords: dyslipidemia; cardiovascular disease; prevention; treatment; risk factors
(This special issue belongs to the Section Cardiovascular Medicine)
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