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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Sex- and Age-Related Differences in Exercise Response: Clinical Implications for Health and Disease

edited by

Rafael A. Casuso

submission deadline 26 Apr 2026 | 2 articles | Viewed by 1318 | Submission Open

Keywords: exercise intervention; clinical exercise physiology; sex differences; age-related response; metabolic disorders; personalized medicine; physical activity; chronic disease management

(This special issue belongs to the Section Sports Medicine)

Recent Advances in the Diagnosis and Treatment of Gastrointestinal Diseases

edited by

Ahamed Khalyfa

submission deadline 27 Apr 2026 | 5 articles | Viewed by 5219 | Submission Open

Keywords: advanced endoscopy; innovation in GI; pathophysiology of GI disorders; artificial intelligence in GI; gastrointestinal diseases

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Advancing Minimally Invasive Spine Surgery: A Special Edition on Endoscopic Spine Surgery

edited by

Adham M. Khalafallah

and Gregory W. Basil

submission deadline 28 Apr 2026 | 4 articles | Viewed by 7058 | Submission Open

Keywords: minimally invasive spine surgery (MIS); endoscopic spine surgery (ESS); spine surgery; percutaneous spine surgery; full-endoscopic spine surgery; biportal endoscopic spine surgery (BESS); unilateral biportal endoscopy (UBE); percutaneous endoscopic lumbar discectomy (PELD); endoscopic decompression; transforaminal endoscopic lumbar discectomy (TELD); interlaminar endoscopic lumbar discectomy (IELD); endoscopic lumbar fusion; endoscopic transforaminal lumbar interbody fusion (Endo-TLIF)

(This special issue belongs to the Section Clinical Neurology)

Recent Advances and Clinical Outcomes of Hip and Knee Arthroplasty

edited by

Andrea Volpin

submission deadline 28 Apr 2026 | 3 articles | Viewed by 2910 | Submission Open

Keywords: hip arthroplasty; knee arthroplasty; joint replacement; clinical outcomes; surgical innovation; patient recovery; prosthetics; perioperative care

(This special issue belongs to the Section Orthopedics)

Selected Papers from the 3rd International Online Conference on Clinical Medicine

edited by

Kent Doi

and

Francisco Guillen-Grima

submission deadline 28 Apr 2026 | 1 articles | Viewed by 1622 | Submission Open

Keywords: cardiology; cardiovascular medicine; nephrology; urology; emergency medicine; nuclear medicine & radiology; general surgery; clinical rehabilitation; respiratory medicine; anesthesiology

Current Trends in Hand Surgery

edited by

Alexandre Kaempfen

and Florian Frueh

submission deadline 28 Apr 2026 | 1 articles | Viewed by 1222 | Submission Open

Keywords: microsurgery; minimally invasive; arthroscopy; sonography; nerve surgery; joint replacement

(This special issue belongs to the Section Orthopedics)

Symptoms and Treatment of Cardiac Amyloidosis

edited by Syed Bukhari

submission deadline 28 Apr 2026 | Viewed by 276 | Submission Open

Keywords: cardiac amyloidosis; transthyretin amyloidosis; light chain amyloidosis; cardiac magnetic resonance; echocardiography; nuclear scintigraphy; endomyocardial biopsy; gene silencers; transthyretin stabilizers; immunotherapy

(This special issue belongs to the Section Cardiology)

Periodontal and Other Associated Oral Diseases: Diagnosis and Management in the Context of Systemic Pathology, 2nd Edition

edited by

Silvia Martu

Liliana-Georgeta Foia

and

Maria Alexandra Mârțu

submission deadline 30 Apr 2026 | 4 articles | Viewed by 8070 | Submission Open

Keywords: periodontitis; oral diseases; periimplantitis; biomarkers; cytokines; oxidative stress markers; PCR test; point-of-care test; CBCT; periodontal treatment; immunomodulatory therapy; local drug delivery

(This special issue belongs to the Section Otolaryngology)

Sequelae of COVID-19: Clinical to Prognostic Follow-Up

edited by

Mariana Tudoran

and

Cristina Tudoran

submission deadline 30 Apr 2026 | 6 articles | Viewed by 5537 | Submission Open

Keywords: COVID-19; post-COVID-19 syndromes; sequelae of COVID-19; pathophysiological pathways; multiorgan sequelae; long-term management of post-COVID-19 syndromes; quality of life; long-term prognosis of COVID-19

(This special issue belongs to the Section Vascular Medicine)

Rehabilitation Strategies for Neurological Disorders: Advances and Insights

edited by Delia Cinteză and Mihai Berteanu

submission deadline 30 Apr 2026 | 5 articles | Viewed by 3726 | Submission Open

Keywords: neurorehabilitation; physical medicine; virtual reality; AI in rehabilitation medicine; robotic rehabilitation; telerehabilitation; advanced technologies; upper neuromotor lesions; peripheral neuropathies; wearable sensor devices; assessment; goal-setting; individual rehabilitation plan

(This special issue belongs to the Section Clinical Rehabilitation)

Interstitial Lung Diseases: New Treatments and Future Directions

edited by Justyna Fijołek

submission deadline 30 Apr 2026 | 1 articles | Viewed by 3643 | Submission Open

Keywords: Interstitial Lung Disease (ILD); pulmonary fibrosis; orphan lung disease; AAV-ILD; occupational ILD; rheumatic lung disease; treatment strategies; emerging therapies; precision medicine; future directions

(This special issue belongs to the Section Respiratory Medicine)

Advances in Gastroenterological Surgery

edited by Alan Biloslavo and Antonio La Greca

submission deadline 30 Apr 2026 | 3 articles | Viewed by 3386 | Submission Open

Keywords: mini-invasive surgery; technology; artificial intelligence; negative pressure; indocyanine green; ultrasound; GE surgery; emergency surgery; precision surgery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Diabetic Retinopathy Screening: Current Advances and Future Options

edited by

Alauddin Bhuiyan

and

Roland Theodore Smith

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1372 | Submission Open

Keywords: diabetic retinopathy; diabetic retinopathy screening; retinal imaging; age-related macular degeneration; artificial intelli-gence; image analysis; color fundus photography; optical coherence tomography imaging; telemedicine

(This special issue belongs to the Section Ophthalmology)

New Advances in the Management of Voice Disorders: 2nd Edition

edited by

Ben Barsties v. Latoszek

submission deadline 30 Apr 2026 | 1 articles | Viewed by 1334 | Submission Open

Keywords: voice disorders; laryngology; laryngoscope; acoustic analysis; dysphonia; voice surgery; diagnosis; treatment; rehabilitation; vocal folds; voice assessment/measures

(This special issue belongs to the Section Otolaryngology)

Clinical Challenges and Innovations in Cochlear Implantation and Hearing Rehabilitation

edited by

Meredith Holcomb

submission deadline 30 Apr 2026 | 1 articles | Viewed by 368 | Submission Open

Keywords: cochlear implant outcomes; clinical efficiency; barriers to care; cochlear implant surgery; cochlear implant referral; cochlear implant evaluation; cochlear implant candidacy; rehabilitation; rehabilitation strategies; quality of life

(This special issue belongs to the Section Otolaryngology)

Skin Cancers: Update on Clinical Treatment and Management

edited by Nazzaro Gianluca

submission deadline 30 Apr 2026 | Viewed by 203 | Submission Open

Keywords: basal cell carcinoma; squamous cell carcinoma; melanoma; skin cancers; dermoscopy; ultrasonography; immunotherapy; biomarker; prevention; diagnosis; treatment; innovative treatments; prognosis

(This special issue belongs to the Section Dermatology)

New Clinical Advances in Depressive Disorders and Treatment-Resistant Depression

edited by Giacomo d'Andrea and Miriam Olivola

submission deadline 30 Apr 2026 | Viewed by 135 | Submission Open

Keywords: treatment-resistant depression; MDD; ketamine; esketamine; rTMS; psylocibin; bipolar depression; clinical pheno-typing; precision psychiatry; biomarkers

(This special issue belongs to the Section Mental Health)

New Clinical Advances in Psoriasis and Psoriatic Arthritis: 2nd Edition

edited by

Diego Orsini

and Alessandra Narcisi

submission deadline 30 Apr 2026 | Viewed by 126 | Submission Open

Keywords: psoriasis; psoriatic arthritis; inflammatory skin disease; inflammatory autoimmune disease; immunotherapy; autoimmunity; comorbidities; therapeutic; diagnosis; treatment; management; biologics

(This special issue belongs to the Section Dermatology)

Orthopedic Approaches to Acute Trauma: Insights and Strategies in Trauma Care

edited by

Gianfilippo Caggiari

submission deadline 30 Apr 2026 | Viewed by 120 | Submission Open

Keywords: acute trauma; orthopedic surgery; fractures and dislocations; ligament injuries; cartilage lesions; post-traumatic degeneration; emergency trauma care; surgical and non-surgical management; rehabilitation strategies; musculo-skeletal injury outcomes

(This special issue belongs to the Section Orthopedics)

Advances in Clinical Craniofacial Reconstructive Surgery

edited by Rami S. Kantar

submission deadline 30 Apr 2026 | Viewed by 119 | Submission Open

Keywords: craniofacial; craniofacial conditions; craniofacial surgery; cleft; cleft lip; cleft palate; reconstructive surgery; craniofacial anomalies

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Insight into Infectious Disease Epidemiology and Public Health

edited by

Francesco Rosiello

and Filomena Pietrantonio

submission deadline 30 Apr 2026 | Viewed by 94 | Submission Open

Keywords: gender medicine; health management; public health; infectious disease; sindemics

(This special issue belongs to the Section Infectious Diseases)

Surgical Insights into Foot and Ankle Diseases

edited by Konstantinos Tsikopoulos

submission deadline 30 Apr 2026 | Viewed by 82 | Submission Open

Keywords: lower limb surgery; infection research; foot and ankle

(This special issue belongs to the Section Orthopedics)

Clinical Updates and New Perspectives of Chronic Pain

edited by Yohannes W. Woldeamanuel

submission deadline 30 Apr 2026 | Viewed by 81 | Submission Open

Keywords: circadian rhythms; chronic pain; clock genes; neuroinflammation; chronotherapy; migraine; cancer survivors; sex differences; racial disparities; personalized medicine

(This special issue belongs to the Section Clinical Neurology)

Advances in Cardiovascular Computed Tomography (CT)

edited by

David C. Rotzinger

submission deadline 30 Apr 2026 | Viewed by 74 | Submission Open

Keywords: computed tomography angiography; cardiovascular imaging; contrast media; spectral computed tomography; quantitative imaging; coronary artery disease; aortic disease; pulmonary embolism; structural heart disease

(This special issue belongs to the Section Cardiovascular Medicine)

Head and Neck Cancer: Clinical Diagnostics and Treatments

edited by Matti Anniko

submission deadline 30 Apr 2026 | Viewed by 67 | Submission Open

Keywords: head and neck cancer; treatment; surgery; chemotherapy; immunotherapy; diagnostics

(This special issue belongs to the Section Otolaryngology)

Antithrombotic Therapy in Special and Overlooked Populations with Cardiovascular Diseases

edited by

Leonardo De Luca

submission deadline 30 Apr 2026 | Viewed by 55 | Submission Open

Keywords: antithrombotic therapy; high-risk patients; PCI; bleeding risk; atrial fibrillation; individualized treatment; real-world evidence; complex cardiovascular disease

(This special issue belongs to the Section Cardiovascular Medicine)

Congenital Heart Disease in Adults (ACHD): Diagnosis, Therapy, and Clinical Management

edited by Mirosław Kowalski

submission deadline 30 Apr 2026 | Viewed by 25 | Submission Open

Keywords: congenital cardiac defect in adults; right ventricular failure; strain echocardiography; ventricular mechanics; cardiac resynchronizing therapy (CRT); Fontan operation; protein-losing enteropathy (PLE)

(This special issue belongs to the Section Cardiology)

Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) and Concomitant Illnesses: Diagnostic and Therapeutic Implications

edited by Kamran Qureshi and Lewis Frey

submission deadline 30 Apr 2026 | Viewed by 23 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease (MASLD); metabolic dysfunction-associated steatohepatitis (MASH); chronic liver diseases; metabolic syndrome; viral hepatitis; autoimmune liver diseases

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

The Role of Cardiac Rehabilitation After Myocardial Infarction, Coronary Artery Bypass Surgery, and in Other Cardiac Diseases

edited by

Aneta Aleksova

submission deadline 1 May 2026 | 3 articles | Viewed by 5762 | Submission Open

Keywords: cardiac rehabilitation; coronary artery disease; myocardial infarction; coronary artery bypass surgery; heart failure; ventricular assist device; heart transplantation; cardiomyopathies; cardiac remodeling; illness perception; treatment adherence; gender difference; biomarkers; endothelial function

(This special issue belongs to the Section Cardiology)

Recent Advancements in Periodontal and Peri-Implant Disease Management

edited by

João Martins de Mello-Neto

and Leticia Helena Theodoro

submission deadline 5 May 2026 | Viewed by 241 | Submission Open

Keywords: periodontal disease; peri-implantitis; periodontal medicine; complications and management

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advancements and Challenges in Reconstructive Urology and Urethral Surgery

edited by

Francesco Chierigo

submission deadline 10 May 2026 | 3 articles | Viewed by 3362 | Submission Open

Keywords: reconstructive urology; urethral surgery; urethroplasty; minimally invasive surgery; robotic-assisted surgery; urinary tract reconstruction; surgical innovation; patient-reported outcomes

(This special issue belongs to the Section Nephrology & Urology)

Advances in Chronic Pain and Related Management

edited by

Sabine Sator

submission deadline 10 May 2026 | Viewed by 136 | Submission Open

Keywords: chronic pain; musculoskeletal pain; neuropathic pain; fibromyalgia syndrome; somatoform disorder; post-COVID syndrome; small fiber disease; invasive pain therapy; vagus stimulation

(This special issue belongs to the Section Anesthesiology)

Quality of Life in Patients with Gynecological Cancers

edited by

Katarzyna Plagens-Rotman

Piotr Merks

and Monika Englert-Golon

submission deadline 10 May 2026 | Viewed by 82 | Submission Open

Keywords: quality of life; gynecology oncology; ovarian cancer; breast cancer; cervical cancer; endometrial cancer; women; gynecological diseases; oncological diseases

(This special issue belongs to the Section Obstetrics & Gynecology)

Prevention and Management of Sexual Dysfunction

edited by Grażyna Jarząbek-Bielecka and Katarzyna Plagens-Rotman

submission deadline 10 May 2026 | Viewed by 68 | Submission Open

Keywords: sexual health; sexual dysfunction; reproductive health; general sexuology; sexological care

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Innovations, Biomarkers, and Challenges in Cancer Immunotherapy

edited by

Mohammad Mousaei Ghasroldasht

and Mahzad Akbarpour

submission deadline 10 May 2026 | Viewed by 66 | Submission Open

Keywords: next-generation cellular therapies; CAR-NK cell therapy; CAR-T cell therapy; combination strategies; exosomes; T-cell engagers; oncolytic viruses; cancer immunotherapy; biomarkers for therapy response; translational immunotherapy; tumor microenvironment modulation; immune evasion mechanisms

(This special issue belongs to the Section Oncology)

Challenging ICU Dogma: Where Routine Practice and Evidence Collide

edited by

Yujiro Matsuishi

and Nobutake Shimojo

submission deadline 10 May 2026 | Viewed by 39 | Submission Open

Keywords: critical care; intensive care unit (ICU); clinical dogma; de-implementation; medical reversal; routine practices; clinical decision-making

(This special issue belongs to the Section Intensive Care)

Revolutionizing Arrhythmia Therapy: Novel Approaches in Pacing and Defibrillation

edited by

Amato Santoro

and

Alberto Palazzuoli

submission deadline 10 May 2026 | Viewed by 34 | Submission Open

Keywords: cardiac resynchronization therapy; conduction system pacing; left bundle branch area pacing; S-ICD; EV-ICD

(This special issue belongs to the Section Cardiology)

Advances in the Management of Chronic Lymphocytic Leukemia

edited by

Alberto Fresa

and

Luca Laurenti

submission deadline 12 May 2026 | 1 articles | Viewed by 533 | Submission Open

Keywords: chronic lymphocytic leukemia; lymphoproliferative disorders; prognostic factors; targeted therapy; CAR T cell; elderly patients; comorbidities

(This special issue belongs to the Section Hematology)

Chronic Kidney Disease Management: Integrating Pharmacotherapy, Biomarkers, and Lifestyle Interventions for Improved Outcomes

edited by

Ioannis Bellos

submission deadline 15 May 2026 | 2 articles | Viewed by 1910 | Submission Open

Keywords: nephrology; chronic kidney disease; cardiovascular risk; risk stratification; biomarkers; evidence-based treatment

(This special issue belongs to the Section Nephrology & Urology)

Thyroid Disorders: New Clinical Diagnosis and Management

edited by

Ioannis P. Iakovou

Rodis D. Paparodis

and

Nicholaos G. Angelopoulos

submission deadline 15 May 2026 | Viewed by 984 | Submission Open

Keywords: thyroid disorders; clinical diagnosis; ultrasound; elastography; thyroid cancer; thyroiditis; hyperthyroidism; hypothyroidism; advanced imaging

(This special issue belongs to the Section Endocrinology & Metabolism)

Clinical Research in Management of Corneal Diseases

edited by Massimo Busin and Angeli Christy Yu

submission deadline 15 May 2026 | 1 articles | Viewed by 414 | Submission Open

Keywords: corneal surgery; corneal transplant; lamellar keratoplasty; deep anterior lamellar keratoplasty; descemet membrane endothelial keratoplasty; descemet stripping automated endothelial keratoplasty; corneal neurotization

(This special issue belongs to the Section Ophthalmology)

Clinical Management of Attention Deficit Hyperactivity Disorder (ADHD)

edited by

Alessandro Pallucchini

submission deadline 15 May 2026 | Viewed by 237 | Submission Open

Keywords: ADHD; addiction; neurodevelopmental disorders; levomethadone

(This special issue belongs to the Section Mental Health)

Neuroendocrine Neoplasms: Epidemiology, Clinical Management, and Emerging Therapies

edited by

H. Christian Weber

submission deadline 15 May 2026 | Viewed by 236 | Submission Open

Keywords: neuroendocrine neoplasms (NENs); epidemiology; biomarkers for NENs; targeted therapies for NENs; carcinoid syndrome; precision medicine; gastrointestinal NENs; advanced endoscopic approaches to NEN treatment; imaging modalities for NENs; survival risk factors in NENs

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Mechanisms and Management of Intracerebral Hemorrhage

edited by Emanuela Crobeddu

submission deadline 15 May 2026 | Viewed by 191 | Submission Open

Keywords: intracerebral hemorrhage; arteriovenous malformation (AVM); dural arteriovenous fistula (DAVF); cavernoma; neuroinflammation; blood– brain barrier; hematoma evacuation; neuroprotection; imaging technologies; vascular lesions

(This special issue belongs to the Section Clinical Neurology)

Clinical Updates on Pediatric Surgery

edited by Carlos Theodore Huerta and Eduardo Alfonso Perez

submission deadline 15 May 2026 | Viewed by 167 | Submission Open

Keywords: pediatric surgery; robotic-assisted surgery; artificial intelligence; enhanced recovery after surgery; minimally inva-sive surgery; augmented reality

(This special issue belongs to the Section Clinical Pediatrics)

Pediatric Pulmonology: Current Hurdles and Future Perspectives

edited by Isabel Delgado-Pecellín and Anselmo Andrés-Martín

submission deadline 15 May 2026 | Viewed by 132 | Submission Open

Keywords: interstitial lung diseases; neonatal screening; complex chronic patients; home mechanical ventilation; severe asthma; telemonitoring; lung development; cystic fibrosis; genetics

(This special issue belongs to the Section Clinical Pediatrics)

Clinical Updates on Maternal Fetal Medicine: 2nd Edition

edited by

Roberta Granese

and

Gabriele Tonni

submission deadline 15 May 2026 | Viewed by 123 | Submission Open

Keywords: diabetes in pregnancy; hypertension in pregnancy; cholestasis in pregnancy; endocrine disorder in pregnancy; sepsis in pregnancy

(This special issue belongs to the Section Obstetrics & Gynecology)

Damage Control Surgery: New Insights into Resuscitation, Operative Strategies and Complications

edited by

Bruno de La Villéon

submission deadline 15 May 2026 | Viewed by 111 | Submission Open

Keywords: damage control surgery; damage control resuscitation; polytrauma management; massive transfusion protocol; hemorrhagic shock; trauma laparotomy; staged laparotomy; temporary abdominal closure; multidisciplinary trauma care

(This special issue belongs to the Section General Surgery)

Root Canal Treatment and Healing Outcomes: Clinical Application of Endodontic Biomaterials and Postoperative Management

edited by

Fausto Zamparini

Carlo Prati

and

Andrea Spinelli

submission deadline 15 May 2026 | Viewed by 89 | Submission Open

Keywords: root canal treatment; healing outcomes; endodontic biomaterials; bioceramic sealers; postoperative management; clinical evidence; periapical healing; post operative pain; dentistry

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Heart Failure: Challenges and Future Options

edited by Pedro Caravaca-Pérez and Marta Farrero-Torres

submission deadline 15 May 2026 | Viewed by 58 | Submission Open

Keywords: heart failure; cardiorenal syndrome; heart transplantation; ventricular assist devices; biomarkers; precision medicine; advanced therapies; diuretic resistance; risk stratification; multidisciplinary care

(This special issue belongs to the Section Cardiovascular Medicine)

Displaying special issue 1151-1200 on page 24 of 31.

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