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Clinical Research in Management of Corneal Diseases
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Clinical Research in Management of Corneal Diseases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: closed (15 May 2026) | Viewed by 1445

Special Issue Editors

Prof. Dr. Massimo Busin

E-Mail Website
Guest Editor
Department of Translational Medicine, University of Ferrara, Ferrara, Italy
Interests: corneal surgery; corneal transplantation; lamellar keratoplasty; deep anterior lamellar keratoplasty; descemet membrane endothelial keratoplasty; descemet stripping automated endothelial keratoplasty
Special Issues, Collections and Topics in MDPI journals
Dr. Angeli Christy Yu

E-Mail Website
Co-Guest Editor
Department of Translational Medicine, University of Ferrara, Ferrara, Italy
Interests: corneal surgery; corneal transplantation; lamellar keratoplasty; deep anterior lamellar keratoplasty; descemet membrane endothelial keratoplasty; descemet stripping automated endothelial keratoplasty

Special Issue Information

Dear Colleagues,

Corneal diseases remain a significant global cause of visual impairment, with advancements in surgical techniques, diagnostics, and therapeutic strategies continually reshaping clinical practice. This Special Issue, “Clinical Research in Management of Corneal Diseases”, aims to highlight the latest innovations and evidence-based approaches in corneal surgery and transplantation.

The field of corneal surgery has witnessed remarkable progress, not only in terms of refinement of corneal transplantation techniques but also other surgical innovations and treatment paradigms. The integration of artificial intelligence and even robotics is promising. 

This Special Issue welcomes original research articles, comprehensive reviews, and clinical studies in corneal surgery. We invite researchers and clinicians to contribute their expertise and insights to this Special Issue, fostering a deeper understanding of the evolving landscape of corneal disease management.

Prof. Dr. Massimo Busin
Guest Editor

Dr. Angeli Christy Yu
Co-Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • corneal surgery
  • corneal transplant
  • lamellar keratoplasty
  • deep anterior lamellar keratoplasty
  • descemet membrane endothelial keratoplasty
  • descemet stripping automated endothelial keratoplasty
  • corneal neurotization

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

11 pages, 1310 KB  
Article
Changes in Corneal Densitometry and Relationship to Corneal Topographical Parameters in Accelerated Corneal Crosslinking for the Treatment of Keratoconus
by Yifan Du, Hanyu Jiang, Fei Mo, Ying Li and Yang Jiang
J. Clin. Med. 2026, 15(8), 3137; https://doi.org/10.3390/jcm15083137 - 20 Apr 2026
Viewed by 296
Abstract
Background/Objectives: To evaluate changes in corneal topography and densitometry (CD) 3 months after accelerated corneal collagen crosslinking (CXL) for keratoconus and to investigate influencing factors. Methods: Twenty-one (41 eyes) patients with KC who underwent accelerated epithelium-off CXL were included in this [...] Read more.
Background/Objectives: To evaluate changes in corneal topography and densitometry (CD) 3 months after accelerated corneal collagen crosslinking (CXL) for keratoconus and to investigate influencing factors. Methods: Twenty-one (41 eyes) patients with KC who underwent accelerated epithelium-off CXL were included in this retrospective observational study; preoperative and 3-month postoperative CD and corneal topographic parameters measured by Pentacam HR were collected. The changes in corneal topographic parameters and CD before and after CXL were subsequently compared, and the correlation between age, corneal topographic parameters and CD changes was analysed. Results: Except for TCT (p = 0.026), no significant changes were observed in topographic parameters (p > 0.05). There was a significant increase in total CD (tCD), CD 0–2 mm and CD 2–6 mm from the whole, anterior and central corneal layers after CXL compared to pre-operation (p < 0.05). The results of the correlating factors showed that age was positively associated with changes in tCD, CD 0–2 mm, and CD 2–6 mm from the whole, anterior and central corneal layer (p < 0.05), which was fully consistent with the regions treated by CXL. Other factors showed only marginal associations and were not consistent with the regions treated by CXL. Conclusions: An increase in CD can be observed in patients with KC at 3 months after undergoing accelerated CXL, and this is particularly focused on the 0–2 mm and 2–6 mm regions of the anterior and central corneal layers. The degree of change in CD was influenced by age, which may suggest differences in corneal response to CXL in KC of different ages. Full article
(This article belongs to the Special Issue Clinical Research in Management of Corneal Diseases)
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12 pages, 2398 KB  
Article
Multicenter European Data of Anatomical Parameters of the Anterior Eye Segment Measured with an Optical Biometer
by Ava Niknahad, Hyeck-Soo Son, Gerd U. Auffarth, Louise Blöck, Giacomo Savini, Catarina P. Coutinho, Joaquín Fernández and Grzegorz Łabuz
J. Clin. Med. 2025, 14(22), 8192; https://doi.org/10.3390/jcm14228192 - 19 Nov 2025
Viewed by 752
Abstract
Background/Objectives: Normative values of ocular parameters can be influenced by a variety of factors. This study evaluates the relationship of axial length (AL), anterior and posterior corneal curvature, anterior chamber, and corneal thickness variables with age, spherical equivalent (SE), and gender. Methods [...] Read more.
Background/Objectives: Normative values of ocular parameters can be influenced by a variety of factors. This study evaluates the relationship of axial length (AL), anterior and posterior corneal curvature, anterior chamber, and corneal thickness variables with age, spherical equivalent (SE), and gender. Methods: A retrospective cohort study at three hospitals identified patients from June 2019 to July 2022. Eyes with no prior history of surgery and anterior segment pathology were included, with one eye per patient being examined by Pentacam AXL Wave (Oculus, Germany). Results: The 1075 patients included had a mean age of 52.9 (± 19.5 years), with 41.5% (446) identified as males. Compared to all variables, anterior chamber angle was most strongly associated with age, with a Spearman’s correlation coefficient (r) of −0.62 (p < 0.001), while AL was most strongly correlated with SE (r = −0.75, p < 0.001). The mean radius of anterior corneal curvature showed a significant positive correlation with SE (r = 0.08, p = 0.013). Between the two genders, males had larger median anterior chamber volume (157.8 versus 147.9 mm3, p < 0.001), depth (p < 0.05 internal and external), AL (24.2 versus 23.7 mm, p < 0.001), and flatter corneas (p < 0.05 anteriorly and posteriorly) compared to females. Conclusions: Age and SE were significantly negatively correlated with AL and anterior chamber parameters. While males showed longer AL and deeper and larger anterior chambers, females had steeper corneas but similar anterior chamber angles. The differences warrant considering age, SE, and gender when interpreting a patient’s examinations against normative data. Full article
(This article belongs to the Special Issue Clinical Research in Management of Corneal Diseases)
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