Journal of Clinical Medicine

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Prof. Dr. Kent Doi

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Guest Editor

Department of Acute Care Medicine, University of Tokyo, Tokyo, Japan
Interests: emergency medicine; critical care medicine; intensive care medicine; fluorescence microscopy; cell biology; molecular biology; neuroscience; acute kidney injury and sepsis
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Francisco Guillen-Grima

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Guest Editor

1. Department of Preventive Medicine, Clinica Universidad de Navarra, University of Navarra, 31008 Pamplona, Spain
2. Navarra Medical Research Institute (IdiSNA), 31008 Pamplona, Spain
3. Center for Biomedical Research Network Epidemiology and Public Health, (CIBERESP), 28029 Madrid, Spain
4. Department of Health Sciences, Public University of Navarra, 31008 Pamplona, Spain
Interests: epidemiology; preventive medicine; public health; methodology
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Special Issue Information

Dear Colleagues,

The 3rd International Online Conference on Clinical Medicine (IOCCM 2025) (https://sciforum.net/event/IOCCM2025), organized by MDPI’s open access journal Journal of Clinical Medicine (Impact Factor 3.0), will take place online from November 17 to 19, 2025. This conference aims to offer a virtual platform for leading scientists to share their latest research discoveries and participate in stimulating discussions. The main topics of the conference include the following:

• Cardiology & Cardiovascular Medicine;
• Nephrology & Urology;
• Emergency Medicine;
• Nuclear Medicine & Radiology;
• General Surgery;
• Clinical Rehabilitation;
• Pulmonology;
• Anesthesiology.

Below are the key dates relating to the conference:

- Abstract Submission: 18 August 2025
- Acceptance Notification: 20 September 2025
- Registration Deadline: 3 November 2025

This Special Issue aims to compile extended versions of the proceedings papers from the conference. Participation in the conference and the publication of abstracts are free of charge. Researchers submitting an abstract to the conference can publish an article in this Special Issue with a discount on the article processing charge if the abstract is accepted.

Prof. Dr. Kent Doi
Prof. Dr. Francisco Guillen-Grima
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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14 pages, 233 KiB

Open AccessReview

The Clinical and Medico-Legal Aspects in the Challenge of Transfusion-Free Organ Transplants: A Scoping Review

by Matteo Bolcato, Ludovico Fava, Aryeh Shander, Christoph Zenger, Kevin M. Trentino, Mario Chisari, Vanessa Agostini, Ivo Beverina, Giandomenico Luigi Biancofiore and Vincenzo De Angelis

J. Clin. Med. 2025, 14(15), 5444; https://doi.org/10.3390/jcm14155444 - 1 Aug 2025

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Abstract

Background: Patient blood management (PBM) strategies have been shown to significantly reduce the use of blood products and enabled surgical procedures to be carried out safely without the need for transfusions. This evidence has raised questions about the possibilities of the “extreme” application of PBM strategies for complex surgical interventions, such as organ transplants, even in patients in whom it is not possible to proceed with transfusion. The aim of this scoping review was to identify and describe the current evidence available in the medical literature on the transplant of the four main solid organs: kidney, heart, liver, and lung in patients declining blood transfusions. Methods: A comprehensive literature search was conducted using PubMed from January 2000 to February 2025. Only articles reporting cases, case series, population samples, or comparative studies describing solid organ transplantation without the use of blood components were included. The results are presented separately for each solid organ. Results: Kidney: Nine studies were included, seven of which reported case reports or case series of kidney or kidney–pancreas transplants, and two articles were comparative studies. Liver: Nine studies reported bloodless liver transplants, eight were case reports or case series, and one was a comparative observational study. Heart: Five studies were included, four of which were case reports of heart transplants; in addition there was a comparative study describing eight heart transplants without the use of blood components to 16 transfusable transplant patients. Lung: Five studies reporting lung transplant without transfusion were reported, four of which were case reports performed in the absence of deaths, and two of which were bilateral. Furthermore, there was an article describing two single lung transplants without the use of blood components compared to ten transfusable transplant patients. Conclusions: The analysis performed demonstrates the possibility, depending on the organ, of performing solid organ transplant procedures without the use of blood components in selected and carefully prepared patients by experienced multidisciplinary teams. Full article

(This article belongs to the Special Issue Selected Papers from the 3rd International Online Conference on Clinical Medicine)

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