Neuroendocrine Neoplasms: Epidemiology, Clinical Management, and Emerging Therapies
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".
Deadline for manuscript submissions: 15 November 2025 | Viewed by 90
Special Issue Editor
2. Gastroenterology & Hepatology, VA Boston Healthcare System, Jamaica Plain Campus, Jamaica Plain, MA 02130, USA
Interests: gastrointestinal hormones and receptors; neuroendocrinology and neuroendocrine tumors; gastric acid secretion and acid-related disorders; obesity and metabolism; functional bowel disorders, including irritable bowel syn-drome and opioid-induced constipation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neuroendocrine neoplasms (NENs) comprise a heterogenous group of rare epithelial neoplasms that can emanate from neuroendocrine cells in many organs, with the majority developing in the luminal gastrointestinal tract, pancreas, or lungs. The incidence of NENs has increased over the last three decades, most dramatically in older adults, with the highest increase in prevalence seen in GI NENs, according to the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database. This increase in incidence is attributed not only to the increased diagnosis of asymptomatic, early-stage disease (for instance, through the wider use of endoscopic procedures in the gastrointestinal tract), but also to the increased recognition and adoption of classification systems for these rare tumors by the WHO. Although uncommon, NENs remain a significant cause of mortality, particularly pulmonary NENs, which often present as aggressive high-grade carcinomas.
Most observations regarding risk factors and demographic profiles across site-specific NENs have been acquired from the SEER program database. Similarly, recent years have seen new insights into the diverse molecular landscape of various NENs, demonstrating the correspondingly diverse tumor biology of NENs at various anatomical sites. Therefore, the design of larger clinical trials for novel treatment options remains a significant challenge. In this Special Issue on NENs, we will address topics concerning the broad diversity of NENs (epidemiology and demographics, different anatomical sites, survival outcomes in different racial/ethnic groups, and risk factors) and their current and future management, including endoscopic approaches to gastrointestinal NENs and emerging therapeutic options based on precision medicine applications.
Dr. H. Christian Weber
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neuroendocrine neoplasms (NENs)
- epidemiology
- biomarkers for NENs
- targeted therapies for NENs
- carcinoid syndrome
- precision medicine
- gastrointestinal NENs
- advanced endoscopic approaches to NEN treatment
- imaging modalities for NENs
- survival risk factors in NENs
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
