Advancements and Challenges in Reconstructive Urology and Urethral Surgery

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".

Deadline for manuscript submissions: 30 October 2025 | Viewed by 224

Special Issue Editor


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Guest Editor
Department of Urology, ASST Santi Paolo e Carlo, University of Milan, Milan, Italy
Interests: reconstructive urology; urologic oncology; prostate cancer
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Special Issue Information

Dear Colleagues,

Reconstructive urology and urethral surgery are pivotal fields in modern urology, addressing complex functional and structural abnormalities of the urinary tract. Despite significant advancements in surgical techniques, biomaterials, and postoperative management, many challenges remain, including high recurrence rates, patient-reported outcomes, and long-term functional success. This Special Issue aims to highlight recent innovations, emerging technologies, and best practices in reconstructive urology, particularly in urethral surgery, with the goal of improving patient outcomes and advancing the field.

We invite original research articles, systematic reviews, and meta-analyses that explore novel surgical techniques, tissue engineering approaches, minimally invasive solutions, and long-term follow-up data in reconstructive urology. Studies assessing the impact of robotic-assisted surgery, patient-centered outcomes, and complications management are particularly encouraged. Additionally, contributions focusing on multidisciplinary approaches integrating urology, plastic surgery, and regenerative medicine will be welcomed.

We encourage researchers, clinicians, and experts in urology, andrology, and surgical innovation to submit their work, fostering a comprehensive and collaborative discussion on the future of reconstructive urology and urethral surgery.

Dr. Francesco Chierigo
Guest Editor

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Keywords

  • reconstructive urology
  • urethral surgery
  • urethroplasty
  • minimally invasive surgery
  • robotic-assisted surgery
  • urinary tract reconstruction
  • surgical innovation
  • patient-reported outcomes

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Published Papers (1 paper)

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Research

13 pages, 1239 KiB  
Article
Impact of Urethroplasty on Erectile Function: A Multicenter Analysis of the International Index of Erectile Function Score Changes Across Different Etiologies of Urethral Stricture
by Mikołaj Frankiewicz, Łukasz Białek, Marta Rydzińska, Michał Skrzypczyk, Rafał Pęksa, Marcin Folwarski, Adam Kaftan, Jakub Krukowski, Adam Kałużny, Marcin Matuszewski and Trauma and Reconstructive Urology Working Party of the European Association of Urology Young Academic Urologists
J. Clin. Med. 2025, 14(9), 2936; https://doi.org/10.3390/jcm14092936 - 24 Apr 2025
Viewed by 122
Abstract
Background/Objectives: Urethral stricture disease, characterized by narrowing of the urethra due to scar tissue, affects urinary and sexual health. While urethroplasty is the standard treatment, its impact on erectile function is less understood. This study examines changes in International Index of Erectile [...] Read more.
Background/Objectives: Urethral stricture disease, characterized by narrowing of the urethra due to scar tissue, affects urinary and sexual health. While urethroplasty is the standard treatment, its impact on erectile function is less understood. This study examines changes in International Index of Erectile Function (IIEF) scores post-urethroplasty across various stricture etiologies, identifies predictors of erectile function outcomes, and explores recovery trajectories following surgery. Methods: This multicenter retrospective study included 103 patients who underwent urethroplasty between 2017 and 2023. Preoperative and postoperative IIEF scores at 3 and 6 or 12 months were analyzed. Stricture etiologies included pelvic fracture urethral injury, transurethral resection, catheterization, idiopathic, and hypospadias. The Wilcoxon signed-rank test and multivariate regression models were used to assess changes in IIEF scores and identify significant predictors. Results: Preoperative erectile function and patient age were significant predictors of postoperative outcomes. Younger patients and those with higher baseline IIEF scores experienced better erectile function post-surgery. Long-term outcomes (6 to 12 months) were significantly worse for strictures involving both penile and bulbar regions. Multivariate analysis showed higher pre-surgery IIEF scores and younger age were associated with better outcomes both short-term (R2 = 0.562) and long-term (R2 = 0.507). Diabetes was associated with worse erectile function outcomes at 3 months post-surgery. Conclusions: Younger patients and those with higher baseline IIEF scores have better erectile function outcomes following urethroplasty. Complex strictures involving both penile and bulbar regions adversely affect long-term outcomes. Additionally, the presence of diabetes is correlated with diminished erectile function in the short-term postoperative period. Full article
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