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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Interdisciplinary Approach on the Oral Cavity Management Due to Musculoskeletal Conditions

edited by Cosmin Sinescu,

Elena Amaricai

and

Virgil-Florin Duma

submission deadline 31 Dec 2025 | 5 articles | Viewed by 19432 | Submission Open

Keywords: rehabilitation medicine; biomechanics; bruxism assessment; general medicine; dental medicine; biomedical imaging; musculoskeletal disorders; shoulder girdle; cervical region; physical therapy; therapeutic exercise; postural correction; dynamic balance; pediatric rehabilitation; sports medicine; quality of life research; general conditions with resonance in the oro-maxillo-facial sphere

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Symptoms and Treatment of Parkinson’s Disease

edited by

Christos Koros

and Nikolaos Papagiannakis

submission deadline 31 Dec 2025 | 5 articles | Viewed by 17445 | Submission Open

Keywords: Parkinson’ s disease; non-motor symptoms; clinical progression; cognitive assessment; genetics; remote monitoring; biomarkers; personalized medicine; device-aided treatments; disease-modifying therapies

(This special issue belongs to the Section Clinical Neurology)

Oral Health and Dental Care: Current Advances and Future Options

edited by

Massimo Amato

Federica Di Spirito

and Alessia Bramanti

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7535 | Submission Open

Keywords: oral health; dental care; technologies; innovation; dental materials

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Challenges in the Field of Psycho-Oncology: Insights from Research

edited by

Ana Bartolo

Sara Monteiro

, Tânia Brandão and Ricardo Teixeira

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6464 | Submission Open

Keywords: cancer; psycho-oncology; survivorship care; psychological distress; quality of life; sustainable development goals; global health; health disparities

(This special issue belongs to the Section Oncology)

New Trends and Challenges in Critical Care Management

edited by

Anna Wrzosek

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4154 | Submission Open

Keywords: critical care; intensive care; extracorporeal organ support; mechanical ventilation; personalized medicine; artificial intelligence; infections; antimicrobial resistance; COVID-19

(This special issue belongs to the Section Intensive Care)

Evidence-Based Diagnosis and Clinical Management of Low Back Pain

edited by

William J. Hanney

and

Michael Masaracchio

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3939 | Submission Open

Keywords: low back pain; classification systems; risk stratification; health services research; management strategies; timing and sequencing; prognosis; predictor; clinical decision making; primary care

(This special issue belongs to the Section Clinical Rehabilitation)

Rare Respiratory Diseases: A Personal and a Public Health Problem: 3rd Edition

edited by

Francisco Dasí

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3826 | Submission Open

Keywords: rare diseases; rare respiratory diseases; alpha-1 antitrypsin deficiency; primary ciliary dyskinesia; cystic fibrosis; idiopathic pulmonary fibrosis; lymphangioleiomyomatosis; interstitial lung diseases; pulmonary arterial hypertension

(This special issue belongs to the Section Respiratory Medicine)

Acute Kidney Injury: Latest Advances and Prospects

edited by

Emanuele de Simone

and Kianoush Kashani

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3678 | Submission Open

Keywords: acute kidney injury (AKI); sepsis; septic shock; renal replacement therapy; intensive care; specialized interventions; biomarkers; risk factors; “ Green Practice” ; nephrology; epidemiology; multidisciplinary approach

(This special issue belongs to the Section Nephrology & Urology)

Clinical Updates on Knee and Hip Arthroplasty

edited by Amarildo Smakaj and Elena Gasbarra

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3305 | Submission Open

Keywords: knee arthroplasty; hip arthroplasty; total joint replacement; minimally invasive arthroplasty; implant durability; postoperative rehabilitation; revision arthroplasty; prosthesis-related complications; periprosthetic joint infection; implant loosening

(This special issue belongs to the Section Orthopedics)

Advances in Clinical Approaches to Breast Cancer Diagnosis and Treatment

edited by

Lorenzo Scardina

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3202 | Submission Open

Keywords: breast cancer; diagnosis; precision medicine; molecular profiling; targeted therapy; breast-conserving surgery; minimally invasive techniques; artificial intelligence; personalized medicine; radiation therapy

(This special issue belongs to the Section Oncology)

Clinical Therapeutic Advances in Bone Fractures

edited by Simon Hackl and Eva Simone Steinhausen

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3001 | Submission Open

Keywords: stem cells; biomechanics; fracture fixation; orthobiologics; rehabilitation; personalized medicine; 3D printing; im-plant coating; nonunion; fracture-related infection

(This special issue belongs to the Section Orthopedics)

Advances in Gastroenterology and Hepatology: Bridging Basic Science, Clinical Insights, and Translational Medicine

edited by

Abdulrahman Ismaiel

and

Ștefan Lucian Popa

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2676 | Submission Open

Keywords: hepatology; gastroenterology; IBD; IBS; MASLD; liver cirrhosis; artificial intelligence; disorders of gut– brain interaction; cancer; gut microbiota; diagnosis; management

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Emerging Clinical Insights into Adolescent Behavioral Development and Mental Health

edited by

Ainzara Favini

and Anne-Marie Iselin

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1760 | Submission Open

Keywords: adolescence; behavioral development; clinical maladjustment; adolescents’ mental health; innovative clinical approach; adolescents’ emotional problems; clinical settings; innovative developmental research; adolescents’ symptoms

(This special issue belongs to the Section Mental Health)

Pregnancy Complications and Maternal-Perinatal Outcomes

edited by

Angelo Sirico

submission deadline 31 Dec 2025 | 3 articles | Viewed by 1746 | Submission Open

Keywords: pregnancy; high-risk; GDM; preeclampsia; fetal growth restriction; diabetes; placenta; ultrasound

(This special issue belongs to the Section Obstetrics & Gynecology)

Novel Advanced Imaging in Cardiology: Current Status and Future Directions

edited by

Moshe Rav-Acha

and

Arik Wolak

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1515 | Submission Open

Keywords: cardiac imaging; cardiac magnetic resonance; echocardiography; computed tomography; trans-thoracic echocardiography global longitudinal strain (GLS) analyses; radiomics

(This special issue belongs to the Section Cardiovascular Medicine)

Children and Adolescent Mood Disorders: Risks and Treatment

edited by

Angelo Fraschetti

and

Emanuela Mari

submission deadline 31 Dec 2025 | Viewed by 1509 | Submission Open

Keywords: emotional dysregulation; mood disorders; adolescence; anxiety; depression; addiction; psychotherapy; pharmacological treatments; prevention programs

(This special issue belongs to the Section Mental Health)

Clinical Updates on Prenatal Diagnosis

edited by Valentina D'Ambrosio

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1225 | Submission Open

Keywords: fetal anomalies; twin pregnancy; fetal therapy; prenatal genetic testing; genome sequencies

(This special issue belongs to the Section Obstetrics & Gynecology)

Recent Progress and Future Directions in Orthopedic Oncology

edited by

Giuseppe Papalia

and Carmine Zoccali

submission deadline 31 Dec 2025 | 1 articles | Viewed by 898 | Submission Open

Keywords: orthopedic oncology; bone tumors; limb-sparing surgery; reconstruction techniques; 3D-printed implants; navigation and robotics; precision medicine in musculoskeletal oncology

(This special issue belongs to the Section Orthopedics)

Perioperative Management in Thoracic Surgery: Current Advances and Future Perspectives

edited by

Roberto Cascone

and

Alfonso Fiorelli

submission deadline 31 Dec 2025 | 1 articles | Viewed by 884 | Submission Open

Keywords: thoracic surgery; perioperative care; ERAS; minimally invasive surgery; interventional pulmonology; preoperative assessment; postoperative management; surgical outcomes; multidisciplinary approach; technology in surgery

(This special issue belongs to the Section Respiratory Medicine)

Innovations in Psychosis and Schizophrenia: New Findings and Implications

edited by

Gabriele Nibbio

submission deadline 31 Dec 2025 | 1 articles | Viewed by 748 | Submission Open

Keywords: schizophrenia; psychosis; psychopathology; neurobiology; assessment; pharmacological treatment; psychosocial interventions

(This special issue belongs to the Section Mental Health)

Clinical Challenges and Advances in Dry Eye Disease and Meibomian Gland Dysfunction

edited by

Salvatore Troisi

and

Livio Vitiello

submission deadline 31 Dec 2025 | 1 articles | Viewed by 404 | Submission Open

Keywords: dry eye disease; ocular surface; corneal disease; conjunctival disease; ocular biomarkers; patient-centered care; advanced diagnostics; regenerative medicine; artificial intelligence; therapeutic innovations

(This special issue belongs to the Section Ophthalmology)

Orthopedic Oncology Updates and Controversial Issues

edited by Yehuda Kollender and Ron Batash

submission deadline 31 Dec 2025 | Viewed by 337 | Submission Open

Keywords: soft tissue sarcoma; bone sarcoma; oligometastatic; atypical behavior tumor; cryosurgery; rare diseases; surgery; radiation therapy; immunotherapy; chemotherapy

(This special issue belongs to the Section Orthopedics)

Updates on Treatment of Chronic Kidney Disease: Novel Approaches and Future Directions

edited by Pietro C. Dattolo and

Aris Tsalouchos

submission deadline 31 Dec 2025 | 1 articles | Viewed by 251 | Submission Open

Keywords: chronic kidney disease; CKD treatment; SGLT2 inhibitors; GLP-1 receptor agonists; non-steroidal MRAs; precision medicine; renal replacement therapy; novel therapeutics; clinical trials; nephrology

(This special issue belongs to the Section Nephrology & Urology)

Advances in Gene Therapy for Retinal Diseases

edited by Tahreem Aman Mir

submission deadline 31 Dec 2025 | Viewed by 221 | Submission Open

Keywords: gene therapy; inherited retinal degenerations; age-related macular degeneration; diabetic retinopathy

(This special issue belongs to the Section Ophthalmology)

Paradigms, Advances and Future Directions in Oral Medicine

edited by

Pia Lopez-Jornet

submission deadline 31 Dec 2025 | 1 articles | Viewed by 191 | Submission Open

Keywords: oral medicine; oral potentially malignant disorders; leukoplakia; oral lichen planus; orofacial pain; biopsy and liquid biopsy; biomarkers

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Trends in Diagnostic Radiology

edited by Wolfram Schwindt, Benjamin Noto and Anne Helfen

submission deadline 31 Dec 2025 | Viewed by 189 | Submission Open

Keywords: diagnostic imaging; radiology; nuclear medicine; hybrid imaging; artificial intelligence; radiomics; quantitative imaging; theranostics; imaging biomarkers; clinical applications

(This special issue belongs to the Section Nuclear Medicine & Radiology)

The Atrial Fibrillation–Heart Failure Interconnection: Challenges and Innovations in Diagnosis and Treatment

edited by

Roberto De Ponti

and

Michele Golino

submission deadline 31 Dec 2025 | Viewed by 152 | Submission Open

Keywords: atrial fibrillation; catheter ablation; ventricular dysfunction; myocardial remodeling; diastolic dysfunction; biomarkers; anti-arrhythmia agents; risk assessment; artificial intelligence; telemedicine

(This special issue belongs to the Section Cardiovascular Medicine)

Progress in the Multimodal Treatment of Pancreatic Disease

edited by

Gennaro Nappo

submission deadline 31 Dec 2025 | Viewed by 149 | Submission Open

Keywords: pancreatic diseases; pancreatic cancer; multimodal treatment; neoadjuvant therapy; imaging techniques; minimally invasive surgery; immunotherapy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Optimizing Outcomes in Deep Vein Thrombosis: A Focus on Interventional Management

edited by Adam Gwozdz

submission deadline 31 Dec 2025 | Viewed by 117 | Submission Open

Keywords: deep vein thrombosis; post-thrombotic syndrome; venous patency; emerging technology; vascular surgery

(This special issue belongs to the Section Vascular Medicine)

Broadening the Knowledge of Autism Spectrum Disorder in Adulthood: Advances in Diagnosis, Assessment and Treatment

edited by

Camilla Gesi

submission deadline 5 Jan 2026 | 1 articles | Viewed by 2637 | Submission Open

Keywords: autism spectrum disorder; adulthood; autism; comorbidity; gender; age-adjusted

(This special issue belongs to the Section Mental Health)

Advances in Diagnosis and Management of Pancreatobiliary Disorders—2nd Edition

edited by

Francesca Lodato

submission deadline 9 Jan 2026 | 3 articles | Viewed by 3093 | Submission Open

Keywords: pancreas diseases; pancreatic tumors; biliary tract diseases and neoplams; ERCP; EUS; cholangioscopy

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Clinical Advances in Pancreatobiliary Diseases

edited by

Kyong Joo Lee

submission deadline 9 Jan 2026 | 1 articles | Viewed by 847 | Submission Open

Keywords: pancreatobiliary diseases; EUS; ERCP; interventional endoscopy; targeted therapy; pancreatobiliary cancer

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Advance in Chronic Total Occlusion Percutaneous Coronary Intervention

edited by Anbukarasi Maran and Kevin Croce

submission deadline 9 Jan 2026 | Viewed by 131 | Submission Open

Keywords: chronic total occlusion (CTO); percutaneous coronary intervention (PCI); innovative techniques; guidewire technology; retrograde PCI; interventional cardiology

(This special issue belongs to the Section Cardiovascular Medicine)

Heart Disease and Chronic Inflammatory Conditions: New Insights

edited by Ofer Kobo and Gilad Margolis

submission deadline 10 Jan 2026 | 4 articles | Viewed by 12847 | Submission Open

Keywords: heart diseases; chronic inflammatory; rheumatoid arthritis; cardiovascular disease; inflammatory bowel disease

(This special issue belongs to the Section Cardiology)

Clinical Guidelines in Critical Care Medicine

edited by

Ana Vujaklija Brajković

Andrej Markota

and Daniela Bandic-Pavlovic

submission deadline 10 Jan 2026 | 3 articles | Viewed by 6167 | Submission Open

Keywords: critical illness; immunocompromised host; biomarkers; thrombocytopenia; blood coagulation disorders; multiple trauma; diagnostic imaging

(This special issue belongs to the Section Intensive Care)

Heart Failure and Coronary Artery Diseases: Cardiovascular Complications and Comorbidities

edited by

Dhrubajyoti Bandyopadhyay

Vikash Jaiswal

and

Adrija Hajra

submission deadline 10 Jan 2026 | 3 articles | Viewed by 4230 | Submission Open

Keywords: heart failure; acute myocardial infarction; coronary artery diseases; cardiac imaging; biomarkers; artificial intelligence

(This special issue belongs to the Section Cardiovascular Medicine)

From Acute Injury to Personalized Prevention—Developing Modern Strategies

edited by

Markus Gesslein

and

Eduard Kurz

submission deadline 10 Jan 2026 | 2 articles | Viewed by 1982 | Submission Open

Keywords: orthopedics; acute injury; personalized prevention; innovative methodologies; musculoskeletal disorders; musculoskeletal injury; conservative therapy; functional testing; intervention

(This special issue belongs to the Section Orthopedics)

Advancements in Spinal Oncology: The Current Landscape

edited by Aladine Elsamadicy and

Daniel M. Sciubba

submission deadline 10 Jan 2026 | 1 articles | Viewed by 1845 | Submission Open

Keywords: spinal oncology; patient outcomes; primary bone tumor; spine metastases; intradural tumors

(This special issue belongs to the Section Clinical Neurology)

Pelvic Organ Prolapse: Clinical Advances and Challenges

edited by

Barbara Bodner-Adler

submission deadline 10 Jan 2026 | 1 articles | Viewed by 270 | Submission Open

Keywords: pelvic organ prolapse; pessary treatment; uterus-preserving prolapse surgery; clinical management; clinical treatment

(This special issue belongs to the Section Obstetrics & Gynecology)

Advanced Physiotherapy Practice in Patients with Musculoskeletal Disorders

edited by

Filippo Maselli

and

Firas Mourad

submission deadline 10 Jan 2026 | Viewed by 155 | Submission Open

Keywords: differential diagnosis; physiotherapy; rehabilitation; multidisciplinary; effectiveness; musculoskeletal disorders; screening for referral; manual therapy; exercise; cognitive behavioral therapy; pain neuroscience

(This special issue belongs to the Section Clinical Rehabilitation)

Advances in Vascular and Endovascular Surgery: Second Edition

edited by

Fadi Taher

and Afshin Assadian

submission deadline 11 Jan 2026 | 4 articles | Viewed by 3328 | Submission Open

Keywords: vascular surgery; endovascular surgery; aortic surgery; peripheral arterial disease; vascular imaging; EVAR; FEVAR; vascular access; vascular education; aneurysms

(This special issue belongs to the Section Vascular Medicine)

Clinical Updates in Physiotherapy for Musculoskeletal Disorders

edited by

Santiago Navarro Ledesma

submission deadline 15 Jan 2026 | 10 articles | Viewed by 27257 | Submission Open

Keywords: musculoskeletal disorders; physiotherapy interventions; lifestyle; psychoneuroimmunology; chronic pain; inflammation; physical therapy

(This special issue belongs to the Section Clinical Rehabilitation)

Physical Therapy in Neurorehabilitation

edited by

Marianna Papadopoulou

and

George K. Papadimas

submission deadline 15 Jan 2026 | 8 articles | Viewed by 20948 | Submission Open

Keywords: physical therapy; transcutaneous electrical nerve stimulation (TENS); muscle strengthening; balance exercising; pain; quality of life; neurodegenerative disorders; neuromuscular disorders; stroke; demyelinating disorders

(This special issue belongs to the Section Clinical Neurology)

Innovative Systemic Treatments for Atopic Dermatitis

edited by

Luigi Gargiulo

submission deadline 15 Jan 2026 | 5 articles | Viewed by 16076 | Submission Open

Keywords: atopic dermatitis; atopic eczema; JAK inhibitors; anti-IL-4; anti-IL-13; dupilumab; tralokinumab; lebrikizumab; abrocitinib; upadacitinib; baricitinib

(This special issue belongs to the Section Dermatology)

Clinical Application of Biomarkers in Cancers

edited by

Monica Florescu

submission deadline 15 Jan 2026 | 3 articles | Viewed by 13959 | Submission Open

Keywords: cancer biomarkers; early detection; personalized therapy; biomarker validation; advanced technologies; clinical implementation

(This special issue belongs to the Section Clinical Laboratory Medicine)

Current Trends and Prospects of Critical Emergency Medicine

edited by Quincy K. Tran

submission deadline 15 Jan 2026 | 8 articles | Viewed by 8269 | Submission Open

Keywords: critically ill patients; critical care; resuscitation; emergency medicine; trends; prospects; outcomes

(This special issue belongs to the Section Emergency Medicine)

Advances in Pulmonary Disease Management and Innovation in Treatment

edited by

Monica Steluța Marc

and

Florin Mihaltan

submission deadline 15 Jan 2026 | 4 articles | Viewed by 6790 | Submission Open

Keywords: severe asthma; COPD; sleep-related breathing disorders; respiratory tract infections; innovative respiratory therapies; translational pulmonary research; pulmonary vascular disease; interstitial lung disease; eHealth in respiratory care

(This special issue belongs to the Section Respiratory Medicine)

Clinical Advances in Assessment Measures and Theoretical Models of Caregivers' Sensitivity and Contingency: 2nd Edition

edited by

Silvia Cimino

submission deadline 15 Jan 2026 | 3 articles | Viewed by 4761 | Submission Open

Keywords: clinical caregiving; sensitivity assessment; contingency modeling; caregiver– patient interactions; mental health outcomes; novel assessment measures; therapeutic responsiveness; caregiver interventions; clinical well-being; care recipient support

(This special issue belongs to the Section Intensive Care)

Pulmonary Embolism—Current and Novel Approaches

edited by Roy Beigel and Shlomi Matetzky

submission deadline 15 Jan 2026 | 3 articles | Viewed by 4616 | Submission Open

Keywords: pulmonary embolism; treatment; coagulation; venous thrombosis; thrombolysis; anticoagulation; risk stratification

(This special issue belongs to the Section Respiratory Medicine)

Clinical Advances in Minimally Invasive Urologic Surgery

edited by