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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Insights into Cardiorenal Metabolic Syndrome

edited by

Caterina Carollo

submission deadline 25 Feb 2026 | 3 articles | Viewed by 4654 | Submission Open

Keywords: cardiorenal medicine; diabetes; chronic renal failure; heart failure; cardiorenal syndrome; nephrocardiology

(This special issue belongs to the Section Cardiovascular Medicine)

Alzheimer’s Disease and Related Disorders: Recent Advances in Prevention, Diagnosis and Therapy

edited by

Daniel H. S. Silverman

submission deadline 25 Feb 2026 | 2 articles | Viewed by 3786 | Submission Open

Keywords: cognition; prodromal; Alzheimer’ s; Alzheimer; dementia; mild cognitive impairment; mild decline in cognition; disease-modifying; amyloid; tau; neuroinflammation; biomarkers; neuroimaging; PET; PET/CT; PET/MRI

(This special issue belongs to the Section Clinical Neurology)

Obesity Surgery—State of the Art

edited by Anna Casajoana

submission deadline 25 Feb 2026 | 2 articles | Viewed by 3384 | Submission Open

Keywords: obesity; bariatric surgery; metabolic surgery; diabetes mellitus type 2; GLP-1

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Recent Advances in Reconstructive Oral and Maxillofacial Surgery

edited by

Luciano Maria Catalfamo

submission deadline 25 Feb 2026 | 2 articles | Viewed by 3158 | Submission Open

Keywords: oral surgery; maxillofacial surgery; new technologies; free flap; reconstructive surgery; artificial intelligence

(This special issue belongs to the Section General Surgery)

Clinical Aspects and Outcomes in Contemporary Colorectal Surgery

edited by

Lior Segev

submission deadline 25 Feb 2026 | 3 articles | Viewed by 2975 | Submission Open

Keywords: colorectal surgery; colorectal cancer; Crohn’ s disease; ulcerative colitis; coloproctology; minimally invasive surgery

(This special issue belongs to the Section General Surgery)

Clinical Research in Palliative Care

edited by Cosimo Chelazzi

submission deadline 25 Feb 2026 | 2 articles | Viewed by 2650 | Submission Open

Keywords: cancer palliative care; total pain; advanced care planning; spiritual care; financial toxicity; cancer-related pain

(This special issue belongs to the Section Clinical Rehabilitation)

Updates in the Orthopedic Management of Foot Disorders: 2nd Edition

edited by

Carlo Biz

and

Pietro Ruggieri

submission deadline 25 Feb 2026 | 2 articles | Viewed by 2393 | Submission Open

Keywords: foot pathologies; diabetic feet; forefoot deformities; oncology surgery; foot tumors; minimally invasive surgery; percutaneous surgery; foot joint arthroscopy; stress fractures

(This special issue belongs to the Section Orthopedics)

Innovations in Advanced Echocardiography

edited by Rebecca T. Hahn and Alexandros Papachristidis

submission deadline 25 Feb 2026 | 1 articles | Viewed by 1663 | Submission Open

Keywords: advanced echocardiography; ultrafast ultrasound; contrast echocardiography; subharmonic aided pressure estima-tion; artificial intelligence; 3D echocardiography

(This special issue belongs to the Section Cardiology)

Non-Small-Cell Lung Cancer: Screening, Diagnosis and Treatment Options in the AI and Omics Era

edited by Miljana Tanić

submission deadline 25 Feb 2026 | 2 articles | Viewed by 1370 | Submission Open

Keywords: lung cancer; NSCLC; radiomics; digital pathology; electronic health records; tumor profiling; AI; machine learning; deep learning; liquid biopsy; early detection; diagnosis; prognosis; therapy; biomarkers; management

(This special issue belongs to the Section Respiratory Medicine)

Helicobacter pylori-Associated Intestinal Diseases and Beyond

edited by

Antonio Facciorusso

submission deadline 25 Feb 2026 | 1 articles | Viewed by 1015 | Submission Open

Keywords: IBD; Hp; stomach; celiac disease; diverticulosis; diverticulitis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Recent Advances in Clinical Pharmacology Based on Pharmacokinetics

edited by

Magdalena Cuciureanu

Cristina Ghiciuc

and

Nina Filip

submission deadline 25 Feb 2026 | Viewed by 972 | Submission Open

Keywords: PK/PD modeling; dose optimization; clinical decision-making tools; therapeutic drug monitoring; personalized medicine

(This special issue belongs to the Section Pharmacology)

Hospital-Acquired Infections: Evolving Threats and Epidemiological Insights

edited by

Amir Nutman

submission deadline 25 Feb 2026 | 1 articles | Viewed by 772 | Submission Open

Keywords: hospital-acquired infections; healthcare-associated infections; antimicrobial resistance; multidrug-resistant organisms (MDRO); infection prevention and control; outbreak investigation; patient safety; healthcare epidemiology

(This special issue belongs to the Section Infectious Diseases)

Clinical Advances of Retinal and Vitreous Diseases: Current Status and Prospect

edited by Lorenzo De Angelis, Francesco Barca and Stanislao Rizzo

submission deadline 25 Feb 2026 | 1 articles | Viewed by 521 | Submission Open

Keywords: vitreoretinal surgery; retinal multimodal imaging; gene therapy; retinal diseases; age-related macular degeneration; vascular retinal disease; imaging technologies in ophthalmology

(This special issue belongs to the Section Ophthalmology)

Application of Echocardiography in Clinical Practice

edited by

Shemy Carasso

submission deadline 25 Feb 2026 | 1 articles | Viewed by 315 | Submission Open

Keywords: echocardiography; three-dimensional imaging; mechanical imaging; strain; artificial intelligence; interventional echocardiography; POCUS; hand-held echocardiography; cancer therapy and cardiotoxicity

(This special issue belongs to the Section Cardiovascular Medicine)

Advancing Clinical Medicine Through Artificial Intelligence (AI) and Digital Technology: 2nd Edition

edited by

Antonio Jorge Forte

Syed Ali Haider

and

Mark Lifson

submission deadline 25 Feb 2026 | Viewed by 246 | Submission Open

Keywords: artificial intelligence; clinical medicine; medical imaging; precision medicine; clinical decision support systems; patient care; healthcare practices; early disease detection; patient outcomes

(This special issue belongs to the Section Intensive Care)

Evidence-Based Physiotherapy: Prospects and Challenges

edited by Roman Nowobilski and

Maciej Płaszewski

submission deadline 25 Feb 2026 | Viewed by 242 | Submission Open

Keywords: evidence-based practice; physiotherapy; critique; certainty of evidence; clinical practice guidelines; implementa-tion; clinical settings; clinical practice; clinical processing

(This special issue belongs to the Section Clinical Rehabilitation)

Clinical Research Progress in Diabetes and Cardiovascular Diseases

edited by

Ken-ichi Aihara

submission deadline 25 Feb 2026 | Viewed by 152 | Submission Open

Keywords: diabetes; cardiovascular diseases; risk factor; vascular function; diagnosis; treatment

(This special issue belongs to the Section Cardiovascular Medicine)

Plastic and Reconstructive Surgery: Clinical Advances and Future Opportunities

edited by Rami S Kantar

submission deadline 25 Feb 2026 | Viewed by 130 | Submission Open

Keywords: plastic surgery; reconstructive surgery; cleft lips; palates; post-traumatic reconstruction; facial transplantation; craniofacial surgery; cleft surgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Current Advances and Future Perspectives of Sepsis and Septic Shock

edited by Filippo Mearelli and Gianni Biolo

submission deadline 25 Feb 2026 | Viewed by 120 | Submission Open

Keywords: sepsis; epidemiology; biomarkers; diagnosis; predictive models; prognostication

(This special issue belongs to the Section Emergency Medicine)

Segmentectomy and Lobectomy in Early-Stage Lung Cancer Management

edited by Yujin Kudo

submission deadline 25 Feb 2026 | Viewed by 115 | Submission Open

Keywords: lung cancer; segmentectomy; lobectomy; thoracic surgery; early-stage NSCLC; oncologic outcomes; pulmonary function; surgical planning

(This special issue belongs to the Section Respiratory Medicine)

Spinal Surgery: Recent Advances and Future Perspectives

edited by

Yoshiharu Kawaguchi

submission deadline 25 Feb 2026 | Viewed by 114 | Submission Open

Keywords: spine surgery; diagnostic technology; AI; images; biomarkers; genetics; robotic surgery; minimum invasive surgery; pain control; VR

(This special issue belongs to the Section Orthopedics)

Allergic and Eosinophilic Diseases: Diagnosis, Treatment and Management (Second Edition)

edited by Aikaterini Detoraki

submission deadline 25 Feb 2026 | Viewed by 114 | Submission Open

Keywords: allergy; eosinophilic diseases; immunology; clinical immunology; asthma; diagnosis; treatment; management

(This special issue belongs to the Section Immunology & Rheumatology)

Clinical Updates of Diagnosis and Treatment in Chronic Kidney Disease (CKD)

edited by

Juan F. Navarro-González

, Carmen Mora-Fernández and

Javier Donate-Correa

submission deadline 25 Feb 2026 | Viewed by 112 | Submission Open

Keywords: CKD; CKD progression; biomarkers; disease-modifying treatments; diabetic kidney disease; cardiorenal disease; glomerunephritis; genetic kidney diseases

(This special issue belongs to the Section Nephrology & Urology)

Clinical Update on the Diagnosis and Treatment of Heart Failure

edited by Giulia Nardi and Alessio Mattesini

submission deadline 26 Feb 2026 | 5 articles | Viewed by 12790 | Submission Open

Keywords: ejection fraction; acute heart failure; multidisciplinary management; right heart failure; left ventricle remodeling systems; HF percutaneous treatment; pharmacotherapy; HF prevention; cardiomyopathies

(This special issue belongs to the Section Cardiovascular Medicine)

Advances in Arrhythmia Diagnosis and Management

edited by Zoltán Csanádi

submission deadline 26 Feb 2026 | 7 articles | Viewed by 9297 | Submission Open

Keywords: catheter ablation; atrial fibrillation; ventricular tachycardia; conduction system pacing; cardiac resynchronization; sudden cardiac death

(This special issue belongs to the Section Cardiology)

Pancreatic Cancer: Novel Strategies of Diagnosis and Treatment

edited by

Camelia Cristina Diaconu

and

Gina Gheorghe

submission deadline 26 Feb 2026 | 2 articles | Viewed by 2599 | Submission Open

Keywords: pancreatic cancer; chronic pancreatitis; pancreatic intraepithelial neoplasia; gastroenterology; clinical innovative diagnostic; clinical treatment strategies

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Orthodontics: State of the Art and Perspectives

edited by

Camelia Szuhanek

and

Irina Nicoleta Zetu

submission deadline 27 Feb 2026 | 9 articles | Viewed by 13357 | Submission Open

Keywords: orthodontics; digital orthodontics; intraoral scanners; facial scanners; treatment planning; interdisciplinary treatment; orthodontic implants

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Unraveling Myopia: Current Science, Clinical Impact, and Future Horizons

edited by Neeraj K Singh and Pablo De Gracia

submission deadline 27 Feb 2026 | 2 articles | Viewed by 2275 | Submission Open

Keywords: accommodation; contact lenses; ophthalmic lenses; myopia progression; epidemiology; myopia control interventions; pharmaceutical treatments; environmental and behavioral risk factors; imaging innovations in myopia

(This special issue belongs to the Section Ophthalmology)

Harnessing Photobiomodulation Light for Therapeutic or Prevention of Human Diseases

edited by

Reem Hanna

submission deadline 28 Feb 2026 | 6 articles | Viewed by 25868 | Submission Open

Keywords: neurorehabilitation; supportive care for cancer; reproductive health; dental and oral diseases; viral and bacterial diseases; wound care; dermatology; sports rehabilitation; bone and musculoskeletal diseases; PBM mechanism; ophthalmology; stem cells and regenerative medicine; pain and addiction management; PBM-tissue interaction

Advances in Child Neurology

edited by

Giuseppina Sgandurra

and

Marco Carotenuto

submission deadline 28 Feb 2026 | 6 articles | Viewed by 17189 | Submission Open

Keywords: pediatric neurological disorders; pediatric sleep disorders; pediatric epilepsy; autoimmune encephalitis; pediatric acute-onset neuropsychiatric syndrome (PANS); pediatric headaches; RASopathies; neurogenetic disorders; developmental coordination disorder (DCD); pedaitric neurological rehabilitation; AI application for diagnosis and therapeutic management of pediatric neurological diseases

(This special issue belongs to the Section Clinical Pediatrics)

Headache Disorders: New Advances in Management and Treatment Strategies: 2nd Edition

edited by

Andreas A. Argyriou

Emmanouil V. Dermitzakis

and

Vikelis Michail

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1973 | Submission Open

Keywords: headache; migraine; cluster headache; tension-type headache; post-traumatic headache; calcitonin gene-related peptide; monoclonal antibodies; preventive therapy; acute treatment; pathophysiology; neuromodulation; pain management; drug development; gepants; ditan

(This special issue belongs to the Section Clinical Neurology)

Tumor Microenvironment—Current Status and Therapeutic Targets

edited by

Rashi Kalra

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1290 | Submission Open

Keywords: tumor microenvironment (TME); cancer immunology; immune checkpoint inhibitors; cancer biology; targeted therapies

(This special issue belongs to the Section Oncology)

Clinical Updates in Cardiovascular Computed Tomography (CT)

edited by

Antonella Meloni

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1215 | Submission Open

Keywords: cardiovascular CT; coronary CTA; plaque imaging; artificial intelligence; low-dose imaging; structural heart disease; cardiac imaging; high-risk plaque; atherosclerosis; coronary artery disease; valve calcification; thrombus detection

(This special issue belongs to the Section Cardiovascular Medicine)

New Insights into Head and Neck Surgery—2nd Edition

edited by

Gábor Dénes Répássy

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1191 | Submission Open

Keywords: otorhinolaryngology; head and neck surgery; ear surgery; sinonasal surgery; skull base surgery; salivary gland surgery; thyroid gland surgery; head and neck cancer surgery

(This special issue belongs to the Section General Surgery)

Clinical Therapeutic Advances of Mitral Regurgitation

edited by Angelo Squeri

submission deadline 28 Feb 2026 | 2 articles | Viewed by 984 | Submission Open

Keywords: mitral regurgitation; mitral valve prolapse; cardiovascular interventions; heart surgery; echocardiography; mag-netic resonance imaging; computed tomography

(This special issue belongs to the Section Cardiovascular Medicine)

Towards a New Paradigm: Opioid-Free and Opioid-Sparing Strategies in Modern Anesthesia

edited by

Kassiani Theodoraki

submission deadline 28 Feb 2026 | 2 articles | Viewed by 957 | Submission Open

Keywords: opioid-free anesthesia; opioid-sparing strategies; multimodal analgesia; regional anesthesia; non-opioid analgesics; enhanced recovery after surgery (ERAS); perioperative pain management; postoperative analgesia; anesthesia innovation; chronic pain prevention; patient-centered anesthesia; clinical outcomes in anesthesia

(This special issue belongs to the Section Anesthesiology)

Neuromuscular Diseases and Musculoskeletal Disorders

edited by

Anna Christakou

submission deadline 28 Feb 2026 | 2 articles | Viewed by 931 | Submission Open

Keywords: neuromuscular diseases; osteoporosis; fractures; muscle weakness; muscle intolerance; shoulder dysfunction; myopathy; physiotherapy; rehabilitation

(This special issue belongs to the Section Clinical Neurology)

Current Trends in Urogynecology: 3rd Edition

edited by

Tomasz Rechberger

submission deadline 28 Feb 2026 | 1 articles | Viewed by 364 | Submission Open

Keywords: urogynecological surgery (uterovaginal prolapse; urinary incontinence; fistulas); OAB; pharmacology; physiotherapy; LUTS

(This special issue belongs to the Section Obstetrics & Gynecology)

Emerging Therapies: Clinical Trials and Insights in Psoriasis

edited by

Beata Kowalewska

and Elżbieta Krajewska-Kułak

submission deadline 28 Feb 2026 | 1 articles | Viewed by 363 | Submission Open

Keywords: psoriasis; clinical trials; biomarkers; psychodermatology; treatment; modern therapy; individualized therapy

(This special issue belongs to the Section Dermatology)

New Advances and Clinical Outcomes of Pediatric Endocrinology

edited by

Gerdi Tuli

submission deadline 28 Feb 2026 | Viewed by 363 | Submission Open

Keywords: congenital hypothyroidism; rare bone diseases; growth hormone deficiency; endocrine sequelae of cancer treatments; disorders of sex development; central diabetes insipidus; gender dysphoria

(This special issue belongs to the Section Clinical Pediatrics)

Epidemiology Associated Risks and Intervention Strategies of Childhood Obesity

edited by

María M. Morales Suárez-Varela

Antonio Castillo-Paredes

and Eduardo Guzmán-Muñoz

submission deadline 28 Feb 2026 | Viewed by 293 | Submission Open

Keywords: childhood obesity; overweight; eating disorders; nutritional programs; psychological interventions; physical activity exercise; sport; physical well-being; mental well-being; quality of life

(This special issue belongs to the Section Clinical Pediatrics)

Current and Emerging Treatment Options in Chronic Liver Diseases

edited by Chandana B. Herath and Michael Praktiknjo

submission deadline 28 Feb 2026 | 1 articles | Viewed by 199 | Submission Open

Keywords: liver disease; liver fibrosis; liver cirrhosis; portal hypertension; liver cancer; therapies; immunological therapies for liver cancer; diabetic liver; type 2 diabetes and obesity; spontaneous bacterial peritonitis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Hysterectomy Surgery—Recent Developments and Emerging Trends

edited by

Anastasia Prodromidou

Themos Grigoriadis

and Dimitrios Zacharakis

submission deadline 28 Feb 2026 | Viewed by 191 | Submission Open

Keywords: hysterectomy; minimally invasive hysterectomy; robotic surgery; vaginal hysterectomy; surgical innovation; perioperative care

(This special issue belongs to the Section Obstetrics & Gynecology)

Inflammatory Bowel Disease: Clinical Pathogenesis and Management Strategies

edited by

Francesco Colombo

submission deadline 28 Feb 2026 | Viewed by 77 | Submission Open

Keywords: epithelial barrier dysfunction; intestinal microbiota dysbiosis; minimally invasive surgery in IBDs; disease monitoring; perianal disease treatment; surgical complications in IBD; prehabilitation; stoma formation and management; timing of surgery in IBDs; risk stratification for IBD surgery; patient-reported outcomes post-surgery

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Recent Advances in Prevention, Management, and Rehabilitation of Head and Neck Injuries

edited by

Giovanni Barassi

, Pier Enrico Gallenga and

Roberta Di Pietro

submission deadline 5 Mar 2026 | 2 articles | Viewed by 2685 | Submission Open

Keywords: neck injuries; whiplash injuries; head injuries; concussion; neck pain; cervicalgia; post-concussive syndrome; post-concussive symptoms; vision disorders; hearing disorders; emergency care; emergency therapies; physical medicine and rehabilitation; musculoskeletal rehabilitation; sports medicine

(This special issue belongs to the Section Sports Medicine)

Sleep and Circadian Rhythms in Patients with Physical and Mental Disorders

edited by

Argyro Pachi

Ioannis Ilias

and

Athanassios Tselebis

submission deadline 10 Mar 2026 | 5 articles | Viewed by 13313 | Submission Open

Keywords: sleep; circadian rhythms; insomnia; depression; physical health; mental health; circadian medicine; chronotype; chronotherapy; melatonin

(This special issue belongs to the Section Mental Health)

Clinical Advancements in Kidney Transplantation

edited by Louise Benning

submission deadline 10 Mar 2026 | 6 articles | Viewed by 10884 | Submission Open

Keywords: kidney transplantation; immunosuppression; immune monitoring; biomarkers; rejection; machine perfusion; graft survival

(This special issue belongs to the Section Nephrology & Urology)

New Insights in the Endovascular Treatment of Aortic Type A Dissection

edited by

Markus Kofler

submission deadline 10 Mar 2026 | 2 articles | Viewed by 4907 | Submission Open

Keywords: aortic dissection; endovascular treatment; type A dissection; thoracic aorta; stent graft; minimally invasive surgery; hybrid procedures; complications; long-term outcomes; patient selection

(This special issue belongs to the Section Cardiology)

Clinical Diagnosis and Management of Corneal Diseases

edited by

Eirini-Kanella Panagiotopoulou

Georgios Labiris

and Panagiota Ntonti

submission deadline 10 Mar 2026 | 2 articles | Viewed by 851 | Submission Open

Keywords: corneal imaging; corneal disease diagnosis; corneal therapeutics; regenerative corneal treatments; artificial intelligence in corneal diagnostics; corneal cross-linking; lamellar keratoplasty

(This special issue belongs to the Section Ophthalmology)

Bladder Cancer: Clinical Diagnosis and Treatment

edited by Răzvan Bardan and Bogdan Petrut

submission deadline 10 Mar 2026 | Viewed by 167 | Submission Open

Keywords: bladder cancer; non-muscle invasive bladder cancer (NMIBC); muscle-invasive bladder cancer (MIBC); urinary biomarkers; immunotherapy; risk stratification; surgical treatment; AI in urology; personalized medicine

(This special issue belongs to the Section Nephrology & Urology)

Displaying special issue 751-800 on page 16 of 32.

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