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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Macrophages in Cancers

edited by

Pierre Tennstedt

submission deadline 20 Oct 2025 | 1 articles | Viewed by 1361 | Submission Open

Keywords: tumor-associated macrophages; tumor microenvironment; monocytes; cancer; cancer therapy; bisphosphonates; cytokines; chemokines; immune response; therapeutic resistance; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Research on Mitochondrial Genetics and Epigenetics

edited by Arianna Montanari

submission deadline 20 Oct 2025 | 1 articles | Viewed by 1353 | Submission Open

Keywords: mitochondrial DNA dynamics; retrograde regulation; epigenetic modulators; mitochondrial diseases; cellular homeostasis

(This special issue belongs to the Section Molecular Biology)

Medicinal Mechanisms of Biologically Active Compounds in Cancer

edited by

Karthik Gourishetti

submission deadline 20 Oct 2025 | 2 articles | Viewed by 1278 | Submission Open

Keywords: biologically active compounds; cancer treatment; apoptosis; tumor growth; natural products; oxidative stress

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Insights into Microbial Dynamics in Agroforestry for Resilience and Climate Adaptation

edited by

Amrita Chakraborty

and

Amit Roy

submission deadline 20 Oct 2025 | 1 articles | Viewed by 1270 | Submission Open

Keywords: agroforestry; soil microbes; plant-microbe interactions; microbial influence; microbiomes; insect-microbe interactions; horizontal gene transfer

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research and Insight into Endocannabinoid System

edited by

Jorge Manzanares

and

Francisco Navarrete

submission deadline 20 Oct 2025 | 1 articles | Viewed by 1189 | Submission Open

Keywords: endocannabinoid system; molecular research; biomarker; translational

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Opioid Research

edited by Matthew E. Layton

submission deadline 20 Oct 2025 | 2 articles | Viewed by 1172 | Submission Open

Keywords: methadone; buprenorphine; hyperbaric oxygen; complementary/alternative/integrative treatments; patient-centered outcomes

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Perspectives on the Synthesis and Application of Hydrogel Materials

edited by

Jieping Fan

submission deadline 20 Oct 2025 | 1 articles | Viewed by 1168 | Submission Open

Keywords: hydrogels; molecular basis; polymeric networks; supermolecular chemistry; three-dimensional structure; mechanical strength; rheologic properties; biomaterial

(This special issue belongs to the Section Materials Science)

Molecular Signatures in Autism Spectrum Disorders

edited by

Nikolay Mehterov

submission deadline 20 Oct 2025 | 1 articles | Viewed by 1167 | Submission Open

Keywords: epigenetics; ncRNA; mRNA; cytokines; mitochondria; inflammation; autism

(This special issue belongs to the Section Molecular Neurobiology)

Systemic and Mucosal Inflammation in Colorectal Cancer: Underlying Factors, Significance, and Related Biomarkers, 2nd Edition

edited by

Paola Sena

submission deadline 20 Oct 2025 | 1 articles | Viewed by 1095 | Submission Open

Keywords: molecular changes; colorectal cancer; normal mucosa; apoptotic proteins; inflammatory mechanism; adenoma– carcinoma sequence; cancer biomarkers

(This special issue belongs to the Section Molecular Oncology)

Diabetes and Metabolic Dysfunction

edited by

Vasilis Tsimihodimos

submission deadline 20 Oct 2025 | 2 articles | Viewed by 1090 | Submission Open

Keywords: diabetes; metabolic dysfunction; glucose metabolism; metabolic disturbances; complications

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances and Insights in Tumorogenesis and Tumor Metastasis

edited by

Sayem Miah

submission deadline 20 Oct 2025 | 1 articles | Viewed by 1088 | Submission Open

Keywords: tumorigenesis; metastasis; biomarkers

(This special issue belongs to the Section Molecular Oncology)

Latest Review Papers in Physical Chemistry and Chemical Physics 2024

edited by

Victor Borovkov

submission deadline 20 Oct 2025 | 1 articles | Viewed by 1039 | Submission Open

Keywords: heterogeneous structures; alignment and surface phenomena; quantum theory; statistical and classical mechanics; molecular structure; chemical kinetics; dynamics; kinetics; photochemistry; spectroscopy

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Novel Therapeutic Strategies in Diabetes

edited by

Aikaterini Andreadi

submission deadline 20 Oct 2025 | 2 articles | Viewed by 980 | Submission Open

Keywords: diabetes mellitus; type 1 and type 2 diabetes; GLP1-RA; SGLT2i; smart pen and CSII; micro and macrovascular complications; cardiovascular risk; diabetic foot

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research in Epilepsy

edited by

Kinga Borowicz

submission deadline 20 Oct 2025 | 1 articles | Viewed by 951 | Submission Open

Keywords: epilepsy; epileptogenesis; antiepileptic drugs; drug resistance; interactions of antiepileptic drugs; multi-omics in epilepsy

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), 2nd Edition

edited by

Vincent C. Lombardi

submission deadline 20 Oct 2025 | Viewed by 933 | Submission Open

Keywords: ME/CFS; PASC; long COVID-19; inflammation; innate immunity; adaptive immunity; mast cell activation; post-infection syndrome; metabolism; autoantibodies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Crop Biotic and Abiotic Stress Tolerance: 4th Edition

edited by

Fazhan Qiu

submission deadline 20 Oct 2025 | 2 articles | Viewed by 925 | Submission Open

Keywords: biotic and abiotic stress tolerance; QTL/gene mapping and clones; gene editing; marker-assisted selection; genomic breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Biomaterials and Therapeutics for Pulp-Dentin Complex Regeneration

edited by

Paulo J. Palma

and

Marco C. Bottino

submission deadline 20 Oct 2025 | Viewed by 901 | Submission Open

Keywords: biomaterials; dental materials; regenerative dentistry; pulp regeneration scaffolds; tissue engineering

(This special issue belongs to the Section Materials Science)

Molecular Studies of Muscle Contraction

edited by

Massimo Reconditi

submission deadline 20 Oct 2025 | 1 articles | Viewed by 901 | Submission Open

Keywords: muscle contraction; actin; myosin; thin and thick filament; cytoskeletal anchoring protein

(This special issue belongs to the Section Molecular Biophysics)

Insights in Multiple Sclerosis (MS) and Neuroimmunology: 2nd Edition

edited by

Michael C. Levin

submission deadline 20 Oct 2025 | 1 articles | Viewed by 859 | Submission Open

Keywords: neurodegeneration; neuroimmunology; macrophage; T-cell; B-cell; antibody; neurons; oligodendrocytes; axon; axonal damage; cell death; multiple sclerosis

(This special issue belongs to the Section Molecular Immunology)

Molecular Research on Skin Disease: From Pathology to Therapy, 2nd Edition

edited by

Elisavet Georgiou

submission deadline 20 Oct 2025 | 1 articles | Viewed by 846 | Submission Open

Keywords: genetic; epigenetic; DNA methylation; skin disease; genetic; gene expression

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Insights into Microglia Heterogeneity and Neurodegeneration

edited by

Maria Anttonietta Panaro

submission deadline 20 Oct 2025 | 1 articles | Viewed by 836 | Submission Open

Keywords: microglia; synapses; stress; aging; heterogeneity; CNS; single-cell RNA sequencing; neurodegenerative diseases

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Perspective in Autoimmune Diseases

edited by Andrés González-García and

Montserrat Fernández-Guarino

submission deadline 20 Oct 2025 | 1 articles | Viewed by 821 | Submission Open

Keywords: interferon; cytokines; lupus nephritis; lupus; type I interferon; vasculitis; IgG4-related disease; B cell; NETs; IL-6; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Structural and Functional Insights into Membrane Transporters: A Tribute to Dr. Ernest Wright

edited by Jeff Abramson

submission deadline 20 Oct 2025 | 1 articles | Viewed by 786 | Submission Open

Keywords: membrane transporters; membrane protein; glucose transport; cell membrane; interface reaction

(This special issue belongs to the Section Molecular Biology)

New Molecular Mechanisms of Genotoxicity

edited by Francesca Marcon and

Roberta Meschini

submission deadline 20 Oct 2025 | Viewed by 784 | Submission Open

Keywords: DNA damage; DNA repair; genotoxicity; carcinogenesis; chronic degenerative diseases; human health; molecular mechanisms

(This special issue belongs to the Section Molecular Toxicology)

Next-Gen Tissue Engineering in Disease Modelling, Drug Discovery and Immunotherapeutics

edited by

Hugo Ronaldo Freitas Caires

submission deadline 20 Oct 2025 | 1 articles | Viewed by 764 | Submission Open

Keywords: tissue engineering; 3D cell culture; biomaterials; disease modelling; immunotherapy; cell-based therapies; organ-on-a-chip

(This special issue belongs to the Section Molecular Biology)

New Molecular Progression of Movement Disorders

edited by

Michał Latalski

and

Pilar Gomez-Garre

submission deadline 20 Oct 2025 | 1 articles | Viewed by 749 | Submission Open

Keywords: movement disorders; molecular mechanisms; neurodegenerative diseases; therapeutic targets; biomarkers; neuroinflammation; protein misfolding; mitochondrial dysfunction; environmental factors; genetic factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Yeast Modeling in Metabolism and Cell Cycle Research

edited by

Teodora Emilia Coldea

submission deadline 20 Oct 2025 | Viewed by 743 | Submission Open

Keywords: yeast modeling; metabolism; cell cycle development; microbial fermentation; bioactive compounds; probiotics; drug targets

(This special issue belongs to the Section Molecular Biology)

Biological Activities and Structure–Activity Relationships of Natural and Non-Natural Compounds

edited by

Eleonora Russo

submission deadline 20 Oct 2025 | 1 articles | Viewed by 742 | Submission Open

Keywords: natural compounds; synthetic compounds; biological activities; structure– activity relationship (SAR); bioavailability; toxicity; computational modeling; drug delivery; nanomedicine

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Regulation of Ion Channels and Transporters

edited by

Susumu Ohya

submission deadline 20 Oct 2025 | 1 articles | Viewed by 702 | Submission Open

Keywords: ion channels; ion transporters; cardiovascular disease; inflammatory disease; cancers; neurogenerative disease; disease microenvironment; drug discovery; drug resistance

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Functional Products for Health Prevention and Promotion

edited by

Aneta Koronowicz

submission deadline 20 Oct 2025 | 1 articles | Viewed by 698 | Submission Open

Keywords: functional foods; food fortification; biofortification; bioactive food ingredients; human nutrition; nutrition and immunity; health prevention; chronic non-communicable diseases; epigenetics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research on Chronic Kidney Disease

edited by

Sohel Julovi

submission deadline 20 Oct 2025 | Viewed by 693 | Submission Open

Keywords: CKD; CVD; CKD-MBD; oxidative stress; inflammation; fibrosis; biochemical markers

(This special issue belongs to the Section Molecular Biology)

Complications of Pregnancy: The Importance of Omics-Based Diagnosis and Therapeutic Approaches

edited by

Alejandra Garcia-Gasca

submission deadline 20 Oct 2025 | 1 articles | Viewed by 678 | Submission Open

Keywords: pregnancy complications; epigenetics; omics; miRNA-based therapies; microbiome analysis; early diagnosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Regulatory Mechanisms in the Hypoxic Environment

edited by Irene Filippi

submission deadline 20 Oct 2025 | 1 articles | Viewed by 654 | Submission Open

Keywords: hypoxia; hypoxia-inducible factors (HIFs); angiogenesis; metabolic adaptation; autophagy; cell survival; chronic obstructive pulmonary disease (COPD); cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Stem Cells in Tissue Engineering

edited by Ichiro Takada

submission deadline 20 Oct 2025 | 1 articles | Viewed by 639 | Submission Open

Keywords: stem cells; transcription factors; transcription co-regulators; chromatin remodeling factors; chromatin receptors; nuclear maintenance and differentiation; iPS cells; iPS-T/NK; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Challenges of Acute Ischemic Stroke

edited by

Marta Iacobucci

submission deadline 20 Oct 2025 | 1 articles | Viewed by 624 | Submission Open

Keywords: stroke; endovascular treatment; intravenous thrombolysis; futile recanalization; microvascular therapy

(This special issue belongs to the Section Molecular Neurobiology)

Uncovering the Basis of Plant Nutrient Uptake, Interactions and Homeostasis: Molecular Mechanisms and Their Applications

edited by

Alessio Aprile

submission deadline 20 Oct 2025 | Viewed by 584 | Submission Open

Keywords: nutrient transport; homeostasis; nutrient signaling and pathways; nitrogen use efficiency; acronutrients; micronutrients; plant nutrition

(This special issue belongs to the Section Molecular Plant Sciences)

Advanced Molecular Research in Benign and Malignant Lung Disease

edited by Biniam Kidane

submission deadline 20 Oct 2025 | 1 articles | Viewed by 562 | Submission Open

Keywords: benign lung disease; lung cancer; molecular biology; inflammation; metastasis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Molecular Basis of Extracellular Vesicles in Health and Diseases—2nd Edition

edited by Taral R. Lunavat

submission deadline 20 Oct 2025 | 1 articles | Viewed by 559 | Submission Open

Keywords: exosomes; microvesicles; extracellular vesicles; genetic material; therapeutics; diagnostics; biomarkers; molecular pathway; liquid biopsy; metabolism; omics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Iodinated Compounds and Molecular Iodine in Human Disease

edited by

Carmen Aceves

submission deadline 20 Oct 2025 | 1 articles | Viewed by 529 | Submission Open

Keywords: iodine; iodinated compounds; oxidized iodine; oxidized iodine supplement

(This special issue belongs to the Section Biochemistry)

Multi-Omics Approaches to Disentangle Pathomechanisms in Neurological Disease

edited by

Francesco Pezzini

and

Stefano Doccini

submission deadline 20 Oct 2025 | Viewed by 493 | Submission Open

Keywords: neurological diseases; molecular mechanisms; neurodegeneration; omics; bioinformatics; disease biomarkers; biochemical pathways; diagnostic and therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Correlation Between Oxidative Stress and Inflammation

edited by Margarete Dulce Bagatini

submission deadline 20 Oct 2025 | Viewed by 477 | Submission Open

Keywords: autoimmune diseases; neurodegenerative diseases; purinergic system; inflammatory processes and oxidative stress

(This special issue belongs to the Section Biochemistry)

Advanced Research on the Detection of Small Metabolites in Biological Fluids

edited by

Stefania Garzoli

submission deadline 20 Oct 2025 | Viewed by 476 | Submission Open

Keywords: metabolomic; biological fluids; GC/MS; HPLC/MS; NMR

(This special issue belongs to the Section Molecular Biology)

Application of Biomarkers in Spinal Muscular Atrophy (SMA)

edited by

Maria Gavriilaki

submission deadline 20 Oct 2025 | Viewed by 472 | Submission Open

Keywords: spinal muscular atrophy; nervous system diseases; therapeutics; drug discovery and development; natural history

(This special issue belongs to the Section Molecular Neurobiology)

New Insights into Kidney Diseases—2nd Edition

edited by

Kan Katayama

submission deadline 20 Oct 2025 | 1 articles | Viewed by 463 | Submission Open

Keywords: kidney disease; focal segmental glomerulosclerosis; genetic kidney disease; minimal change disease; nephrotic syndrome; podocyte

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Pediatric Brain Tumors: Unraveling the Complexity of Pathogenesis and Identifying New Therapeutic Targets

edited by Xiao-Nan Li and Holly Lindsay

submission deadline 20 Oct 2025 | Viewed by 460 | Submission Open

Keywords: brain tumor; pediatric tumor biology; molecular subtyping; radiation therapy; genetic and epigenetic abnormalities; tumorigenesis investigation; targeted therapy; diagnostic markers; therapy resistance; tumor relapse

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Chromatin Structure and Dynamics

edited by Stephanie Portillo-Ledesma

submission deadline 20 Oct 2025 | Viewed by 454 | Submission Open

Keywords: chromatin structure and dynamics; genome architecture; epigenetic regulation

(This special issue belongs to the Section Biochemistry)

Current Insights for the Development of Emerging Photovoltaics Through Molecular Research

edited by

Dimitris A. Chalkias

Elias Stathatos

and

Aikaterini K. Andreopoulou

submission deadline 20 Oct 2025 | Viewed by 441 | Submission Open

Keywords: molecular photovoltaics; perovskite solar cells; quantum dot solar cells; organic solar cells; dye-sensitized solar cells; molecular design and engineering; molecular semiconductors

(This special issue belongs to the Section Materials Science)

Pathogenic Proteins in Neurodegenerative Diseases: From Pathogenesis to Therapeutic Innovations

edited by

Minseok Song

and

Nidhi Puranik

submission deadline 20 Oct 2025 | 1 articles | Viewed by 437 | Submission Open

Keywords: Alzheimer’ s disease; Parkinson’ s disease; amyotrophic lateral sclerosis; frontotemporal dementia; lewy bodies dementia; amyloid β -protein; τ -protein; α -synuclein; TDP-43; neurotransmitter; neuropeptide; protein misfolding; protein Homeostasis; neuroinflammatory proteins; post-translational modifications

(This special issue belongs to the Section Molecular Neurobiology)

New Insights into Airway Smooth Muscle: From Function to Dysfunction

edited by

Hiroaki Kume

submission deadline 20 Oct 2025 | Viewed by 436 | Submission Open

Keywords: contraction; proliferation; migration; airway hyperresponsiveness; airway remodeling; β 2-adrenergic receptors; muscarinic receptor; Th2 inflammation; non-Th2 inflammation; oxidative stress; lysophospholipids; intracellular signal transduction processes; Ca2+ signaling; interactions with other cells (inflammatory cells and epithelium); asthma; COPD

(This special issue belongs to the Section Molecular Biology)

Exploring Amazon Bioactives: Novel Anti-Pathogen Therapeutics and Pharmaceutical Breakthroughs

edited by Marta Chagas Monteiro,

Nélio Teixeira Machado

and Pedro Roosevelt Romão

submission deadline 20 Oct 2025 | Viewed by 429 | Submission Open

Keywords: waste biomass; thermochemical processes; bio-oils; phenolic compounds; anti-inflammatory actions; antiviral mechanisms; cancer; cytokine/chemokine regulation; inflammatory conditions/diseases; innate immunity; immune response; immunomodulatory and anti-infective effects; immunomodulation; immunotoxicology; medicinal chemistry; neglected tropical diseases; parasitic disease; purinergic signaling

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Displaying special issue 2801-2850 on page 57 of 69.

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