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Molecular Research on Skin Disease: From Pathology to Therapy, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 October 2025 | Viewed by 677

Special Issue Editor


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Guest Editor
Laboratory of Biological Chemistry, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Interests: epigenetics; genetics; transcriptomics; cutaneous lymphomas
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Special Issue Information

Dear Colleagues,

Skin diseases, both benign and malignant, are considered a major health problem due to their high prevalence and associated morbidity. This is expected to worsen in the future due to the increase in the population’s average life expectancy.

Over the last years, accumulating data on cellular and molecular pathways has increased our knowledge regarding the pathogenesis of skin diseases and helped to introduce novel therapeutic strategies. Nevertheless, many questions remain unanswered, e.g., the identification of patients who will benefit from each therapy or the effect of the combination of genetic and environmental factors. The importance of epigenetic changes in an organ constantly exposed to the environment is underestimated. A comprehensive characterization of genetic, epigenetic, and transcriptional aberrations by high-throughput analysis methodologies is needed to further elucidate the crosstalk of these changes in the development of skin diseases.

This Special Issue is open to basic and translational research articles, as well as reviews, that cover recent advances in the identification of mechanisms, biomarkers, or putative therapeutic targets in this field.

Dr. Elisavet Georgiou
Guest Editor

Manuscript Submission Information

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Keywords

  • genetic
  • epigenetic
  • DNA methylation
  • skin disease
  • genetic
  • gene expression

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Published Papers (1 paper)

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Review

31 pages, 837 KiB  
Review
Extracellular Vesicles and Their Role in Skin Inflammatory Diseases: From Pathogenesis to Therapy
by Xuan Lei, Sabine Ring, Shiying Jin, Sonali Singh and Karsten Mahnke
Int. J. Mol. Sci. 2025, 26(8), 3827; https://doi.org/10.3390/ijms26083827 - 18 Apr 2025
Viewed by 399
Abstract
Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are released into the extracellular space by almost all known cell types. They facilitate communication between cells by transferring bioactive molecules, which impact both physiological processes and the development of diseases. EVs play a [...] Read more.
Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are released into the extracellular space by almost all known cell types. They facilitate communication between cells by transferring bioactive molecules, which impact both physiological processes and the development of diseases. EVs play a crucial role in the pathogenesis of various diseases by participating in multiple pathological processes. They contribute to disease progression by triggering cytokine release, modulating immune cell activity, and inducing inflammatory and immune responses. Beyond their pathological implications, EVs also offer significant therapeutic potential. Both natural and engineered EVs show great potential in the fields of targeted therapy, drug delivery, and immune modulation in dermatological applications. The development of EV-based treatments is showing promise in advancing patient outcomes, particularly in chronic inflammatory and immune-mediated skin conditions. This review comprehensively examined the biogenesis, classification, and functional roles of EVs, including advanced methods for their isolation and characterization. Furthermore, we summarized recent studies highlighting the involvement of EVs in four major inflammatory skin diseases: psoriasis, atopic dermatitis, systemic lupus erythematosus, and wound healing. Full article
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