Molecular Research and Insight into Endocannabinoid System
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 October 2025 | Viewed by 1024
Special Issue Editors
Interests: endocannabinoid system; psychiatry; animal models; alcohol addiction; cannabis use disorders
Special Issues, Collections and Topics in MDPI journals
Interests: cannabinoids; addiction; psychiatry; neurology; translational research; molecular biology; neuropsychopharmacology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Since the discovery of the main phytocannabinoids of the cannabis plant and then of the main components of the endocannabinoid system (ECS) (cannabinoid receptors (CB1r and CB2r), endogenous ligands (anandamide and 2-arachidonylglycerol) and both synthetic and metabolic enzymes) the wide distribution of this neuromodulatory system and its crucial involvement in the functional regulation of the central nervous system have become apparent. In this sense, there has been significant interest in recent decades in identifying and understanding the role of the ECS in physiological conditions and how it is altered in various psychiatric, neurological and addictive disorders. Similarly, emphasis has been placed on understanding the effects of functional manipulation of this system through phytocannabinoids and synthetic cannabinoids, focusing on the potential therapeutic benefits that could be derived for treating brain diseases.
Thus, it is crucial to learn more about the ECS-related molecular mechanisms involved to identify the targets that could play a relevant role, as well as the opportunities that this knowledge would offer in developing new therapeutic strategies based on the modulation of the different components that make up the ECS. In this sense, this Special Issue aims to collect original articles (basic or clinical) and reviews (narrative or systematic) that focus on molecular research, providing new insights about the role of the ECS in physiological or pathological conditions from a translational point of view through preclinical and/or clinical data.
Prof. Dr. Jorge Manzanares
Dr. Francisco Navarrete
Guest Editors
Manuscript Submission Information
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Keywords
- endocannabinoid system
- molecular research
- biomarker
- translational
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