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Advances and Insights in Tumorogenesis and Tumor Metastasis

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 October 2025 | Viewed by 1077

Special Issue Editor

Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Interests: cell signaling; molecular cancer biology; chromatin biology; tumorogenesis; tumor metastasis

Special Issue Information

Dear Colleagues,

The interplay of tumorigenesis and metastasis remains one of the most significant challenges in cancer research, further complicated by the multifaceted nature of cancer progression and an incomplete understanding of metastatic processes. Technological advances have illuminated crucial genetic and proteomic variations distinguishing cancerous tissues from their normal counterparts. Despite this development, several obstacles, including a lack of precise molecular mechanisms of tumor metastasis and validated biomarkers, make it difficult to select suitable candidates for clinical trials that effectively target both tumorigenesis and metastasis. Efforts to unravel the precise molecular mechanisms of tumor spread and develop accurate preclinical models are imperative for the careful design of clinical trials to improve patient outcomes. In this Special Issue, we welcome manuscripts aimed at advancing our understanding of the mechanisms behind cancer's initiation and metastasis, uncovering novel molecular targets, as well as the development of accurate preclinical models that may foster clinical trial advancements and navigate therapy development challenges.

Dr. Sayem Miah
Guest Editor

Manuscript Submission Information

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Keywords

  • tumorigenesis
  • metastasis
  • biomarkers

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Published Papers (1 paper)

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Research

15 pages, 2523 KiB  
Article
Tumor Regulatory Effect of 15-Hydroxyprostaglandin Dehydrogenase (HPGD) in Triple-Negative Breast Cancer
by Joselyn Padilla, Bok-Soon Lee, Allen Kim, Yea-In Park, Avani Bansal and Jiyoung Lee
Int. J. Mol. Sci. 2025, 26(5), 1912; https://doi.org/10.3390/ijms26051912 - 23 Feb 2025
Viewed by 632
Abstract
Prostaglandin regulation is known to play a pivotal role in tumorigenesis; however, the contributions of the prostaglandin-metabolizing enzyme 15-hydroxyprostaglandin dehydrogenase (HPGD) to cancer development remain poorly understood. In this study, we investigate the effects of HPGD on cell viability, proliferation, anchorage-independent growth, and [...] Read more.
Prostaglandin regulation is known to play a pivotal role in tumorigenesis; however, the contributions of the prostaglandin-metabolizing enzyme 15-hydroxyprostaglandin dehydrogenase (HPGD) to cancer development remain poorly understood. In this study, we investigate the effects of HPGD on cell viability, proliferation, anchorage-independent growth, and migration in triple-negative breast cancer (TNBC), an aggressive subtype of breast cancer. Overexpression of HPGD in human TNBC cells resulted in both positive and negative regulation of cell proliferation and colony formation, with these effects occurring independent of prostaglandin E2 (PGE2). In contrast, overexpression of the mouse homolog, Hpgd, in murine TNBC cells led to a consistent but modest reduction in cell viability and colony formation, indicating that HPGD activity varies depending on species and cell line context. Notably, TNBC cells expressing a mutant form of Hpgd (Hpgdmut), which lacks the ability to bind PGE2, exhibited similar functional outcomes in cell viability and colony formation as those expressing wild-type Hpgd (HpgdWT). These findings suggest that HPGD may exert its tumorigenic effects through non-enzymatic mechanisms, potentially by involving modulation of KRAS signaling in human TNBC cells. Our results highlight the diverse roles of HPGD in cancer biology, particularly in the context of TNBC, and point to non-enzymatic pathways as a significant aspect of its tumorigenic activity. Full article
(This article belongs to the Special Issue Advances and Insights in Tumorogenesis and Tumor Metastasis)
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