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Systemic and Mucosal Inflammation in Colorectal Cancer: Underlying Factors, Significance, and Related Biomarkers, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: closed (30 March 2025) | Viewed by 1042

Special Issue Editor

Special Issue Information

Dear Colleagues,

Colorectal cancer (CRC) is the fourth most common tumor type in the world. Genetic and environmental factors contribute to the carcinogenesis of colorectal epithelial cells. It is widely accepted that the persistence of chronic inflammation, such as inflammatory bowel disease, is one of the most important environmental factors in the formation of CRC and that unbalanced cell proliferation and cell death can lead to carcinogenesis. The function of the immune system and the genetic and acquired molecular mechanisms by which it regulates the phenotype, function, or fate of tumor cells are still much debated. However, it is certain that multiple mechanisms are involved in cellular stress and determine cell survival and death. Although somatic genetic changes and subsequent clonal expansion and the polymeric framework leading to cancer can be provided by colorectal adenoma–carcinoma sequences, much controversy remains regarding changes that may occur in the early stages of CRC in morphologically normal tissues.

Dr. Paola Sena
Guest Editor

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Keywords

  • molecular changes
  • colorectal cancer
  • normal mucosa
  • apoptotic proteins
  • inflammatory mechanism
  • adenoma–carcinoma sequence
  • cancer biomarkers

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Published Papers (1 paper)

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Research

14 pages, 805 KiB  
Article
Relationship Between Systemic Inflammatory Response Exponents, Levels of ADAM10, ADAM17 Proteins and Selected Clinical Parameters in Patients with Colorectal Cancer: Original Research Study
by Magdalena Sikora-Skrabaka, Katarzyna Weronika Walkiewicz, Dariusz Waniczek, Joanna Katarzyna Strzelczyk and Ewa Nowakowska-Zajdel
Int. J. Mol. Sci. 2025, 26(3), 1104; https://doi.org/10.3390/ijms26031104 - 27 Jan 2025
Viewed by 813
Abstract
Chronic inflammation is a confirmed risk factor for colorectal cancer (CRC). Indicators of systemic inflammatory response (SIR), such as neutrophil-to-lymphocyte ratio (NLR) or platelet-to-lymphocyte ratio (PLR), are easily accessible indicators of the generalized inflammatory response. At the molecular level, inflammation-related carcinogenesis involves proteins [...] Read more.
Chronic inflammation is a confirmed risk factor for colorectal cancer (CRC). Indicators of systemic inflammatory response (SIR), such as neutrophil-to-lymphocyte ratio (NLR) or platelet-to-lymphocyte ratio (PLR), are easily accessible indicators of the generalized inflammatory response. At the molecular level, inflammation-related carcinogenesis involves proteins from the adamalysin family: ADAM10 and ADAM17. The aim of the study was to assess NLR and PLR and their relationship with selected clinical parameters in CRC patients, as well as the correlation between ADAM10 and ADAM17 in tumor tissue and matched surgical margins with NLR and PLR values. Tumor tissue material matched surgical margins, and blood was collected from 66 patients who underwent surgery because of CRC. The concentrations of ADAM10 and ADAM17 in the collected material were tested using the enzyme-linked immunosorbent assay (ELISA) method. SIR parameters (NLR, PLR) were also determined. The results were statistically analyzed and compared with selected clinical parameters. Results: The study showed that PLR was lower in patients with comorbid cardiovascular diseases (CVD). In patients who underwent preoperative treatment, both the NLR and PLR values were higher than in patients who underwent primary surgery. There was also a negative correlation between ADAM17 concentrations in the surgical margin and PLR values. In conclusion, the presence of additional diseases such as CVD or diabetes mellitus type 2 (DMT2) or the use of preoperative treatment should be taken into account when assessing SIR parameters in CRC patients. Moreover, no clear correlations have been found between ADAM10 and ADAM17 and SIR parameters. Full article
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