Molecular Crosstalk Between Metabolic Dysregulation and Neuropsychiatric Disorders: Novel Therapeutic Perspectives
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 5
Special Issue Editors
Interests: neuropharmacology; antidepressant drugs; metabolic disorders; neurodegenerative diseases; experimental pharmacology
Special Issue Information
Dear Colleagues,
Metabolic dysregulation associated with obesity, insulin resistance, and type 2 diabetes, plays a critical role in the onset and progression of neuropsychiatric disorders such as depression, anxiety, and cognitive decline. These conditions frequently coexist and share complex molecular crosstalk, involving neuroinflammation, oxidative stress, mitochondrial dysfunction, altered neurotransmission, impaired neuroendocrine signaling, and gut–brain axis dysregulation. Despite the existence of numerous pharmacological and non-pharmacological treatment options, many patients with neuropsychiatric disorders do not respond to current therapies, and the underlying molecular mechanisms remain unclear.
The objective of this Special Issue is to collate pioneering research that explores the converging molecular pathways between metabolic dysfunction and neuropsychiatric disorders, along with the therapeutic targeting of these pathways. Contributions that elucidate specific mechanistic links between metabolic disturbances and neuropsychiatric pathophysiology, present novel pharmacological and non-pharmacological interventions, translational and experimental studies, and innovative treatment modalities are particularly welcomed. We hereby extend an invitation to submit original research articles and comprehensive reviews. These submissions should be aimed at delivering a focused and forward-looking perspective on novel therapeutic opportunities at the intersection of metabolism and brain health.
We look forward to receiving your valuable contributions to this Special Issue.
Dr. Aleksandra Szopa
Dr. Anna D. Serefko
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- metabolic dysregulation
- neuropsychiatric disorders
- molecular crosstalk
- neuroinflammation
- mitochondrial dysfunction
- neuroendocrine signaling
- gut–brain axis
- innovative therapeutic strategies
- natural compounds
- drug repurposing
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
