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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Macrophages in Cancers
edited by
submission deadline 20 Oct 2025 | 1 articles | Viewed by 1367 | Submission Open
Keywords: tumor-associated macrophages; tumor microenvironment; monocytes; cancer; cancer therapy; bisphosphonates; cytokines; chemokines; immune response; therapeutic resistance; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Research on Mitochondrial Genetics and Epigenetics
edited by Arianna Montanari
submission deadline 20 Oct 2025 | 1 articles | Viewed by 1365 | Submission Open
Keywords: mitochondrial DNA dynamics; retrograde regulation; epigenetic modulators; mitochondrial diseases; cellular homeostasis
(This special issue belongs to the Section Molecular Biology)
Medicinal Mechanisms of Biologically Active Compounds in Cancer submission deadline 20 Oct 2025 | 2 articles | Viewed by 1303 | Submission Open
Keywords: biologically active compounds; cancer treatment; apoptosis; tumor growth; natural products; oxidative stress
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Insights into Microbial Dynamics in Agroforestry for Resilience and Climate Adaptation submission deadline 20 Oct 2025 | 1 articles | Viewed by 1278 | Submission Open
Keywords: agroforestry; soil microbes; plant-microbe interactions; microbial influence; microbiomes; insect-microbe interactions; horizontal gene transfer
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research and Insight into Endocannabinoid System submission deadline 20 Oct 2025 | 1 articles | Viewed by 1201 | Submission Open
Keywords: endocannabinoid system; molecular research; biomarker; translational
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Opioid Research
edited by Matthew E. Layton
submission deadline 20 Oct 2025 | 2 articles | Viewed by 1199 | Submission Open
Keywords: methadone; buprenorphine; hyperbaric oxygen; complementary/alternative/integrative treatments; patient-centered outcomes
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Signatures in Autism Spectrum Disorders
edited by
submission deadline 20 Oct 2025 | 1 articles | Viewed by 1176 | Submission Open
Keywords: epigenetics; ncRNA; mRNA; cytokines; mitochondria; inflammation; autism
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Perspectives on the Synthesis and Application of Hydrogel Materials
edited by
submission deadline 20 Oct 2025 | 1 articles | Viewed by 1175 | Submission Open
Keywords: hydrogels; molecular basis; polymeric networks; supermolecular chemistry; three-dimensional structure; mechanical strength; rheologic properties; biomaterial
(This special issue belongs to the Section Materials Science)
Diabetes and Metabolic Dysfunction submission deadline 20 Oct 2025 | 2 articles | Viewed by 1114 | Submission Open
Keywords: diabetes; metabolic dysfunction; glucose metabolism; metabolic disturbances; complications
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Systemic and Mucosal Inflammation in Colorectal Cancer: Underlying Factors, Significance, and Related Biomarkers, 2nd Edition
edited by
submission deadline 20 Oct 2025 | 1 articles | Viewed by 1101 | Submission Open
Keywords: molecular changes; colorectal cancer; normal mucosa; apoptotic proteins; inflammatory mechanism; adenoma– carcinoma sequence; cancer biomarkers
(This special issue belongs to the Section Molecular Oncology)
Advances and Insights in Tumorogenesis and Tumor Metastasis
edited by
submission deadline 20 Oct 2025 | 1 articles | Viewed by 1090 | Submission Open
Keywords: tumorigenesis; metastasis; biomarkers
(This special issue belongs to the Section Molecular Oncology)
Latest Review Papers in Physical Chemistry and Chemical Physics 2024
edited by
submission deadline 20 Oct 2025 | 1 articles | Viewed by 1054 | Submission Open
Keywords: heterogeneous structures; alignment and surface phenomena; quantum theory; statistical and classical mechanics; molecular structure; chemical kinetics; dynamics; kinetics; photochemistry; spectroscopy
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Novel Therapeutic Strategies in Diabetes submission deadline 20 Oct 2025 | 2 articles | Viewed by 1023 | Submission Open
Keywords: diabetes mellitus; type 1 and type 2 diabetes; GLP1-RA; SGLT2i; smart pen and CSII; micro and macrovascular complications; cardiovascular risk; diabetic foot
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research in Epilepsy
edited by
submission deadline 20 Oct 2025 | 1 articles | Viewed by 955 | Submission Open
Keywords: epilepsy; epileptogenesis; antiepileptic drugs; drug resistance; interactions of antiepileptic drugs; multi-omics in epilepsy
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), 2nd Edition submission deadline 20 Oct 2025 | Viewed by 934 | Submission Open
Keywords: ME/CFS; PASC; long COVID-19; inflammation; innate immunity; adaptive immunity; mast cell activation; post-infection syndrome; metabolism; autoantibodies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Crop Biotic and Abiotic Stress Tolerance: 4th Edition
edited by
submission deadline 20 Oct 2025 | 2 articles | Viewed by 933 | Submission Open
Keywords: biotic and abiotic stress tolerance; QTL/gene mapping and clones; gene editing; marker-assisted selection; genomic breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Biomaterials and Therapeutics for Pulp-Dentin Complex Regeneration submission deadline 20 Oct 2025 | Viewed by 922 | Submission Open
Keywords: biomaterials; dental materials; regenerative dentistry; pulp regeneration scaffolds; tissue engineering
(This special issue belongs to the Section Materials Science)
Molecular Studies of Muscle Contraction
edited by
submission deadline 20 Oct 2025 | 1 articles | Viewed by 907 | Submission Open
Keywords: muscle contraction; actin; myosin; thin and thick filament; cytoskeletal anchoring protein
(This special issue belongs to the Section Molecular Biophysics)
Molecular Research on Skin Disease: From Pathology to Therapy, 2nd Edition
edited by
submission deadline 20 Oct 2025 | 1 articles | Viewed by 879 | Submission Open
Keywords: genetic; epigenetic; DNA methylation; skin disease; genetic; gene expression
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Insights in Multiple Sclerosis (MS) and Neuroimmunology: 2nd Edition
edited by
submission deadline 20 Oct 2025 | 1 articles | Viewed by 869 | Submission Open
Keywords: neurodegeneration; neuroimmunology; macrophage; T-cell; B-cell; antibody; neurons; oligodendrocytes; axon; axonal damage; cell death; multiple sclerosis
(This special issue belongs to the Section Molecular Immunology)
Novel Insights into Microglia Heterogeneity and Neurodegeneration submission deadline 20 Oct 2025 | 1 articles | Viewed by 863 | Submission Open
Keywords: microglia; synapses; stress; aging; heterogeneity; CNS; single-cell RNA sequencing; neurodegenerative diseases
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Perspective in Autoimmune Diseases
edited by Andrés González-García and
submission deadline 20 Oct 2025 | 1 articles | Viewed by 829 | Submission Open
Keywords: interferon; cytokines; lupus nephritis; lupus; type I interferon; vasculitis; IgG4-related disease; B cell; NETs; IL-6; biomarkers
(This special issue belongs to the Section Molecular Immunology)
Structural and Functional Insights into Membrane Transporters: A Tribute to Dr. Ernest Wright
edited by Jeff Abramson
submission deadline 20 Oct 2025 | 1 articles | Viewed by 818 | Submission Open
Keywords: membrane transporters; membrane protein; glucose transport; cell membrane; interface reaction
(This special issue belongs to the Section Molecular Biology)
New Molecular Mechanisms of Genotoxicity
edited by Francesca Marcon and
submission deadline 20 Oct 2025 | Viewed by 794 | Submission Open
Keywords: DNA damage; DNA repair; genotoxicity; carcinogenesis; chronic degenerative diseases; human health; molecular mechanisms
(This special issue belongs to the Section Molecular Toxicology)
Next-Gen Tissue Engineering in Disease Modelling, Drug Discovery and Immunotherapeutics submission deadline 20 Oct 2025 | 1 articles | Viewed by 767 | Submission Open
Keywords: tissue engineering; 3D cell culture; biomaterials; disease modelling; immunotherapy; cell-based therapies; organ-on-a-chip
(This special issue belongs to the Section Molecular Biology)
New Molecular Progression of Movement Disorders submission deadline 20 Oct 2025 | 1 articles | Viewed by 753 | Submission Open
Keywords: movement disorders; molecular mechanisms; neurodegenerative diseases; therapeutic targets; biomarkers; neuroinflammation; protein misfolding; mitochondrial dysfunction; environmental factors; genetic factors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biological Activities and Structure–Activity Relationships of Natural and Non-Natural Compounds
edited by
submission deadline 20 Oct 2025 | 1 articles | Viewed by 747 | Submission Open
Keywords: natural compounds; synthetic compounds; biological activities; structure– activity relationship (SAR); bioavailability; toxicity; computational modeling; drug delivery; nanomedicine
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Yeast Modeling in Metabolism and Cell Cycle Research submission deadline 20 Oct 2025 | Viewed by 746 | Submission Open
Keywords: yeast modeling; metabolism; cell cycle development; microbial fermentation; bioactive compounds; probiotics; drug targets
(This special issue belongs to the Section Molecular Biology)
Complications of Pregnancy: The Importance of Omics-Based Diagnosis and Therapeutic Approaches submission deadline 20 Oct 2025 | 1 articles | Viewed by 717 | Submission Open
Keywords: pregnancy complications; epigenetics; omics; miRNA-based therapies; microbiome analysis; early diagnosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Functional Products for Health Prevention and Promotion
edited by
submission deadline 20 Oct 2025 | 1 articles | Viewed by 714 | Submission Open
Keywords: functional foods; food fortification; biofortification; bioactive food ingredients; human nutrition; nutrition and immunity; health prevention; chronic non-communicable diseases; epigenetics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Regulation of Ion Channels and Transporters
edited by
submission deadline 20 Oct 2025 | 1 articles | Viewed by 708 | Submission Open
Keywords: ion channels; ion transporters; cardiovascular disease; inflammatory disease; cancers; neurogenerative disease; disease microenvironment; drug discovery; drug resistance
(This special issue belongs to the Section Molecular Biology)
Molecular Research on Chronic Kidney Disease
edited by
submission deadline 20 Oct 2025 | Viewed by 696 | Submission Open
Keywords: CKD; CVD; CKD-MBD; oxidative stress; inflammation; fibrosis; biochemical markers
(This special issue belongs to the Section Molecular Biology)
Molecular Regulatory Mechanisms in the Hypoxic Environment
edited by Irene Filippi
submission deadline 20 Oct 2025 | 1 articles | Viewed by 666 | Submission Open
Keywords: hypoxia; hypoxia-inducible factors (HIFs); angiogenesis; metabolic adaptation; autophagy; cell survival; chronic obstructive pulmonary disease (COPD); cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Stem Cells in Tissue Engineering
edited by Ichiro Takada
submission deadline 20 Oct 2025 | 1 articles | Viewed by 653 | Submission Open
Keywords: stem cells; transcription factors; transcription co-regulators; chromatin remodeling factors; chromatin receptors; nuclear maintenance and differentiation; iPS cells; iPS-T/NK; tissue engineering
(This special issue belongs to the Section Molecular Biology)
Challenges of Acute Ischemic Stroke
edited by
submission deadline 20 Oct 2025 | 1 articles | Viewed by 628 | Submission Open
Keywords: stroke; endovascular treatment; intravenous thrombolysis; futile recanalization; microvascular therapy
(This special issue belongs to the Section Molecular Neurobiology)
Advanced Molecular Research in Benign and Malignant Lung Disease
edited by Biniam Kidane
submission deadline 20 Oct 2025 | 1 articles | Viewed by 604 | Submission Open
Keywords: benign lung disease; lung cancer; molecular biology; inflammation; metastasis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Uncovering the Basis of Plant Nutrient Uptake, Interactions and Homeostasis: Molecular Mechanisms and Their Applications
edited by
submission deadline 20 Oct 2025 | Viewed by 588 | Submission Open
Keywords: nutrient transport; homeostasis; nutrient signaling and pathways; nitrogen use efficiency; acronutrients; micronutrients; plant nutrition
(This special issue belongs to the Section Molecular Plant Sciences)
The Molecular Basis of Extracellular Vesicles in Health and Diseases—2nd Edition
edited by Taral R. Lunavat
submission deadline 20 Oct 2025 | 1 articles | Viewed by 582 | Submission Open
Keywords: exosomes; microvesicles; extracellular vesicles; genetic material; therapeutics; diagnostics; biomarkers; molecular pathway; liquid biopsy; metabolism; omics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Iodinated Compounds and Molecular Iodine in Human Disease
edited by
submission deadline 20 Oct 2025 | 1 articles | Viewed by 555 | Submission Open
Keywords: iodine; iodinated compounds; oxidized iodine; oxidized iodine supplement
(This special issue belongs to the Section Biochemistry)
Multi-Omics Approaches to Disentangle Pathomechanisms in Neurological Disease submission deadline 20 Oct 2025 | Viewed by 495 | Submission Open
Keywords: neurological diseases; molecular mechanisms; neurodegeneration; omics; bioinformatics; disease biomarkers; biochemical pathways; diagnostic and therapeutic targets
(This special issue belongs to the Section Molecular Neurobiology)
Application of Biomarkers in Spinal Muscular Atrophy (SMA)
edited by
submission deadline 20 Oct 2025 | Viewed by 478 | Submission Open
Keywords: spinal muscular atrophy; nervous system diseases; therapeutics; drug discovery and development; natural history
(This special issue belongs to the Section Molecular Neurobiology)
Correlation Between Oxidative Stress and Inflammation
edited by Margarete Dulce Bagatini
submission deadline 20 Oct 2025 | Viewed by 477 | Submission Open
Keywords: autoimmune diseases; neurodegenerative diseases; purinergic system; inflammatory processes and oxidative stress
(This special issue belongs to the Section Biochemistry)
Advanced Research on the Detection of Small Metabolites in Biological Fluids
edited by
submission deadline 20 Oct 2025 | Viewed by 477 | Submission Open
Keywords: metabolomic; biological fluids; GC/MS; HPLC/MS; NMR
(This special issue belongs to the Section Molecular Biology)
Pathogenic Proteins in Neurodegenerative Diseases: From Pathogenesis to Therapeutic Innovations
edited by and
submission deadline 20 Oct 2025 | 1 articles | Viewed by 470 | Submission Open
Keywords: Alzheimer’ s disease; Parkinson’ s disease; amyotrophic lateral sclerosis; frontotemporal dementia; lewy bodies dementia; amyloid β -protein; τ -protein; α -synuclein; TDP-43; neurotransmitter; neuropeptide; protein misfolding; protein Homeostasis; neuroinflammatory proteins; post-translational modifications
(This special issue belongs to the Section Molecular Neurobiology)
New Insights into Kidney Diseases—2nd Edition
edited by
submission deadline 20 Oct 2025 | 1 articles | Viewed by 467 | Submission Open
Keywords: kidney disease; focal segmental glomerulosclerosis; genetic kidney disease; minimal change disease; nephrotic syndrome; podocyte
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Pediatric Brain Tumors: Unraveling the Complexity of Pathogenesis and Identifying New Therapeutic Targets
edited by Xiao-Nan Li and Holly Lindsay
submission deadline 20 Oct 2025 | Viewed by 461 | Submission Open
Keywords: brain tumor; pediatric tumor biology; molecular subtyping; radiation therapy; genetic and epigenetic abnormalities; tumorigenesis investigation; targeted therapy; diagnostic markers; therapy resistance; tumor relapse
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Chromatin Structure and Dynamics
edited by Stephanie Portillo-Ledesma
submission deadline 20 Oct 2025 | Viewed by 456 | Submission Open
Keywords: chromatin structure and dynamics; genome architecture; epigenetic regulation
(This special issue belongs to the Section Biochemistry)
Current Insights for the Development of Emerging Photovoltaics Through Molecular Research submission deadline 20 Oct 2025 | Viewed by 444 | Submission Open
Keywords: molecular photovoltaics; perovskite solar cells; quantum dot solar cells; organic solar cells; dye-sensitized solar cells; molecular design and engineering; molecular semiconductors
(This special issue belongs to the Section Materials Science)
New Insights into Airway Smooth Muscle: From Function to Dysfunction
edited by
submission deadline 20 Oct 2025 | Viewed by 439 | Submission Open
Keywords: contraction; proliferation; migration; airway hyperresponsiveness; airway remodeling; β 2-adrenergic receptors; muscarinic receptor; Th2 inflammation; non-Th2 inflammation; oxidative stress; lysophospholipids; intracellular signal transduction processes; Ca2+ signaling; interactions with other cells (inflammatory cells and epithelium); asthma; COPD
(This special issue belongs to the Section Molecular Biology)
Exploring Amazon Bioactives: Novel Anti-Pathogen Therapeutics and Pharmaceutical Breakthroughs
edited by Marta Chagas Monteiro, and Pedro Roosevelt Romão
submission deadline 20 Oct 2025 | Viewed by 429 | Submission Open
Keywords: waste biomass; thermochemical processes; bio-oils; phenolic compounds; anti-inflammatory actions; antiviral mechanisms; cancer; cytokine/chemokine regulation; inflammatory conditions/diseases; innate immunity; immune response; immunomodulatory and anti-infective effects; immunomodulation; immunotoxicology; medicinal chemistry; neglected tropical diseases; parasitic disease; purinergic signaling
(This special issue belongs to the Section Bioactives and Nutraceuticals)
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