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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Design of Bioactive Agents and Interaction with Biological Systems

edited by

Josef Jampilek

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1141 | Submission Open

Keywords: natural and synthetic compounds; bioactive agents and materials; design and discovery; targeting; intermolecular interactions; omics; structure and dynamics of biomolecules; theoretical analysis of biomolecular structures; analytical and biophysical methods; molecular biology/biochemistry; chemical biology/biological chemistry

(This special issue belongs to the Section Molecular Biology)

Targeting Metabolic Reprogramming: From Pathogenesis to Therapeutic Strategies

edited by

Beatriz García-Díaz

Alejandro Escamilla

and

Raquel Sanchez-Varo

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1129 | Submission Open

Keywords: metabolism; therapy; mitochondria; pathogenesis; bioenergetics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Vegetable Breeding and Molecular Research

edited by

Ai-Sheng Xiong

and

Mengyao Li

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1118 | Submission Open

Keywords: vegetable breeding; gene editing; omics; molecular breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research on Rhizobia

edited by

Socorro Mesa

, María J. Delgado and

Germán Tortosa

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1109 | Submission Open

Keywords: biodiversity; environmental factors; plant– rhizobia interaction; nitrogen fixation; regulation; signaling; symbiosis

(This special issue belongs to the Section Molecular Microbiology)

Antimicrobial Peptides in Reproductive Health and Disease

edited by

Ga-Hyun Son

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1099 | Submission Open

Keywords: antimicrobial peptides; preterm birth; molecular mechanisms; microbiome; immune system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antimicrobial Nanomaterials: Approaches, Strategies and Applications

edited by

Andrea Bernardos

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1079 | Submission Open

Keywords: nanotechnology; biocides; antimicrobials; controlled release; drug delivery; antimicrobial agents; antimicrobial resistance; infection; nanoparticles

(This special issue belongs to the Section Materials Science)

Genetics and Breeding for Sugar Crops

edited by Muqing Zhang

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1061 | Submission Open

Keywords: sugarcane; molecular genetics and breeding; plant pathology; stress biology; GWAS; QTL; precision breeding; molecular marker; gene editing; transgene

(This special issue belongs to the Section Molecular Plant Sciences)

Effects of Stressors During Pregnancy and Breastfeeding on the Child: Molecular Perspectives

edited by

Anna Weronika Sobańska

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1050 | Submission Open

Keywords: xenobiotics; drugs; gestation; breastfeeding; fetus; placenta; child’ s development; teratogenicity; central nervous system

(This special issue belongs to the Section Molecular Biology)

Arthritis: Focus on Pathologies, Symptoms and Therapy

edited by

Katarína Bauerová

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1036 | Submission Open

Keywords: rheumatoid arthritis; autoimmune; pathogenesis; strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanistic Insights, Therapeutic Potential, and Applications of Natural Bioactive Compounds

edited by

Jianqiang Xu

and

Yanshuo Han

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1015 | Submission Open

Keywords: oxidative stress; inflammation; chronic diseases; natural bioactive compounds; plant-derived molecules; redox homeostasis; anti-inflammatory mechanisms; antioxidant activity; drug discovery; synergistic effects; combination therapies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Phytochemicals of Natural Products: Source, Analysis, and Bioactivities

edited by

Yu-Kuo Chen

, Chi-I Chang and Chi-Chien Lin

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1012 | Submission Open

Keywords: phytochemicals; bioactive compounds; natural products; bioactivities; purification; chemoprevention; chemotherapy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Metabolomics in Coronary Artery Disease: From Pathogenesis to Personalized Medicine

edited by

Tomasz Urbanowicz

submission deadline 20 Dec 2025 | 1 articles | Viewed by 987 | Submission Open

Keywords: coronary artery disease (CAD); atherosclerosis; epicardial disease; CAD pathogenesis; personalized approach; drug response; metabolomic

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Rapeseed: Genetic Breeding, Key Trait Mining and Genome

edited by Hongbo Chao

submission deadline 20 Dec 2025 | 2 articles | Viewed by 962 | Submission Open

Keywords: rapeseed (Brassica napus L.); genetic breeding; genomic improvement; molecular markers; genome-wide association studies (GWAS); multi-omics integration; CRISPR gene editing; marker-assisted selection (MAS); stress resistance traits; yield and oil content improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Ovarian Cancer: Pathogenesis, Biomarkers and Treatment

edited by Alessandro Antonio Buda

submission deadline 20 Dec 2025 | 1 articles | Viewed by 959 | Submission Open

Keywords: ovarian cancer; radiotherapy; diagnosis; prevention; treatment; fertility sparing

(This special issue belongs to the Section Molecular Oncology)

Molecular Research of Abiotic Stress in Plants

edited by Deguo Han

submission deadline 20 Dec 2025 | 2 articles | Viewed by 955 | Submission Open

Keywords: abiotic stress; salt stress; drought stress; plant

(This special issue belongs to the Section Molecular Plant Sciences)

Antiviral Strategies Targeting Capsid Proteins: Intervention from Assembly to Function

edited by

Yuqing Wu

submission deadline 20 Dec 2025 | 2 articles | Viewed by 944 | Submission Open

Keywords: viral capsid protein; assembly modulator/intervention; virus variants; antiviral therapeutics; assembly– disassembly

(This special issue belongs to the Section Macromolecules)

Epilepsy: From Molecular Basis to Therapy, 2nd Edition

edited by

Henry Hing Cheong Lee

submission deadline 20 Dec 2025 | 1 articles | Viewed by 924 | Submission Open

Keywords: genetic epilepsy; post-traumatic epilepsy; neurodevelopmental disorder; glutamate; GABA; ionic homeostasis; disease-modifying therapy; in vitro; in vivo; animal model; gene replacement therapy; gene editing; protein misfolding; small molecule; pharmacokinetics; pharmacodynamics; translational research; biomarker; clinical trial

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Insights into Functional Nanomaterials: Application-Related Structural Analysis

edited by Zoltán Dudás

submission deadline 20 Dec 2025 | 1 articles | Viewed by 915 | Submission Open

Keywords: functional porous nanomaterials; structure– activity relationship; molecular structure; characterization; nanoporous materials

(This special issue belongs to the Section Molecular Nanoscience)

Imaging Molecules in Biomedical Research

edited by

Manuela Malatesta

submission deadline 20 Dec 2025 | 1 articles | Viewed by 902 | Submission Open

Keywords: biomedicine; histochemistry; immunohistochemistry; in situ hybridization; magnetic resonance imaging; optical imaging; photoacoustic imaging; ultrasound imaging; Raman microscopy

(This special issue belongs to the Section Biochemistry)

Cardioprotection and Mitochondrial Signaling: Insights from Molecular Mechanisms to Therapeutic Strategies

edited by Cecilia Zazueta

submission deadline 20 Dec 2025 | 1 articles | Viewed by 889 | Submission Open

Keywords: cardioprotection; mitochondrial signaling; mitochondrial dysfunction; heart failure; ischemia/reperfusion; mitochondria; reactive oxygen species

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Plant Reproductive Development

edited by Zsolt Pónya and

Iman Mirmazloum

submission deadline 20 Dec 2025 | 1 articles | Viewed by 864 | Submission Open

Keywords: plant reproduction; sexual reproduction; gamete recognition; zygote formation; embryogenesis; endosperm development; seed maturation; plant developmental biology; epigenetic regulation; gene expression; cellular signalling pathways; protein interactions; hormonal controls

(This special issue belongs to the Section Molecular Plant Sciences)

Treatment of Neurodegenerative Diseases with Natural Products

edited by

Eugene Huh

submission deadline 20 Dec 2025 | 1 articles | Viewed by 855 | Submission Open

Keywords: neurodegenerative diseases; natural product; misfolding protein aggregation; oxidative stress; neuroinflammation; autophagy; apoptosis; microbiota– gut– brain axis; therapeutic; prevention

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Research in Probiotic Yeasts: Molecular Aspects

edited by

Maurizio Ciani

and Francesca Comitini

submission deadline 20 Dec 2025 | 1 articles | Viewed by 854 | Submission Open

Keywords: probiotic yeasts; molecular mechanisms; mycocins active; compounds; functional compounds

(This special issue belongs to the Section Molecular Microbiology)

Drug Delivery Systems in Veterinary Medicine: Innovations and Applications

edited by

Hualin Fu

submission deadline 20 Dec 2025 | 1 articles | Viewed by 854 | Submission Open

Keywords: design of novel veterinary drug delivery systems; methods of preparing a veterinary drug delivery system; mechanisms of action of veterinary drug delivery systems; impact of veterinary drug delivery systems on in vivo processes of veterinary drugs; clinical evaluation of veterinary drug delivery systems

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insights: Transitioning Fertility Research from the Laboratory to Clinical Practice

edited by Ekaterini Domali

submission deadline 20 Dec 2025 | 1 articles | Viewed by 844 | Submission Open

Keywords: IVF/ICSI; male infertility; female infertility; fertility outcomes; endocrine disruptors; oxidative and reductive stress; molecular biology; biomarkers; proteomics; metabolomics; and transcriptomics; cell lines; early pregnancy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pharmacokinetics of Psychoactive Substances: Molecular and Forensic Aspects

edited by

Angelo Montana

and

Fabrizio Lo Faro

submission deadline 20 Dec 2025 | Viewed by 835 | Submission Open

Keywords: psychoactive substances; pharmacokinetics; forensic Toxicology; forensic pathology; toxicological biomarkers; cerebral damage; in vitro; in vivo; and in silico models; new Psychoactive Substances (NPS); new synthetic opioids; liquid chromatography-high resolution mass spectrometry (LC-HRMS/MS); liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography; tandem mass spectrometry (GC-MS/MS)

(This special issue belongs to the Section Molecular Pharmacology)

Viral Diseases of the Respiratory System—Molecular Mechanisms and Pathogenesis: 3rd Edition

edited by

Andreas Beineke

submission deadline 20 Dec 2025 | 1 articles | Viewed by 773 | Submission Open

Keywords: respiratory diseases; pneumonia; pneumotropic viruses; pathogenesis; host– pathogen interaction; pulmonary pathology; immunopathology; immunity; disease prevention; treatment; zoonotic diseases; antiviral therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Development of Dopaminergic Neurons, 4th Edition

edited by

Yasemin M. Akay

submission deadline 20 Dec 2025 | 2 articles | Viewed by 766 | Submission Open

Keywords: neuron; dopamine; mDA; signalling pathways; human stem cell

(This special issue belongs to the Section Molecular Neurobiology)

Biocomposite Hydrogels for Biomedical Applications

edited by

Leonard Ionut Atanase

submission deadline 20 Dec 2025 | 1 articles | Viewed by 753 | Submission Open

Keywords: hydrogels; biocomposite; micro/nanoparticles; electrospun fibers; inorganic particles; tissue engineering; drug delivery; 3D printing

(This special issue belongs to the Section Materials Science)

Recent Advances in Protein Folding and Misfolding

edited by

Ho-Jin Lee

submission deadline 20 Dec 2025 | Viewed by 738 | Submission Open

Keywords: protein folding; protein misfolding; 3D protein structure; CRISPR/Cas 9

(This special issue belongs to the Section Molecular Biophysics)

Emerging Insights into Phytohormone Signaling in Plants

edited by Meng Zhang

submission deadline 20 Dec 2025 | 1 articles | Viewed by 715 | Submission Open

Keywords: phytohormone; signal transduction; evolutionary and functional diversity; implications for plant science and agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

Development and Validation of New Analytical Methods for the Determination of Drugs and Their Metabolites

edited by

Anna Petruczynik

submission deadline 20 Dec 2025 | 1 articles | Viewed by 709 | Submission Open

Keywords: drugs; drug formulations; pharmacokinetics; metabolism studies; analytical techniques

(This special issue belongs to the Section Molecular Pharmacology)

Electron Transport Mechanism in Optoelectronic Materials

edited by Paolo Umari

submission deadline 20 Dec 2025 | Viewed by 685 | Submission Open

Keywords: photovoltaics; density functional theory; quantum chemistry; optoelectronic devices; semiconductors; polymers; charge transport

(This special issue belongs to the Section Materials Science)

Role of Ion Channels in Human Health and Diseases

edited by

Sheng-Nan Wu

submission deadline 20 Dec 2025 | Viewed by 682 | Submission Open

Keywords: sodium current; potassium current; ion channel kinetics; excitable cells; treatments; pathophysiology

(This special issue belongs to the Section Molecular Biology)

Naturally Occurring Bioactive Compounds, Neuroinflammation and Cognitive Dysfunction: Molecular and Biochemical Mechanisms

edited by

Tosin Olasehinde

submission deadline 20 Dec 2025 | 1 articles | Viewed by 674 | Submission Open

Keywords: neuroinflammation; cognitive dysfunction; medicinal plants; bioactive compounds; neurodegenerative diseases; molecular mechanisms; anti-inflammatory

(This special issue belongs to the Section Molecular Toxicology)

Latest Advances in Diabetes Research and Practice

edited by Ezekiel Uba Nwose

submission deadline 20 Dec 2025 | 1 articles | Viewed by 660 | Submission Open

Keywords: diabetes mellitus; cardiovascular risk; metabolic syndrome; antioxidants; oxidative stress; antiplatelet monitoring; evidence-based medicine; laboratory medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Immune-Liver Axis—from Disease Pathogenesis to Therapeutic Target

edited by

Beata Kasztelan-Szczerbińska

submission deadline 20 Dec 2025 | 1 articles | Viewed by 644 | Submission Open

Keywords: immune response; inflammation; liver disease; liver injury; liver cirrhosis; immune-related liver disease; alcohol-related liver disease; metabolic dysfunction-associated steatotic liver disease (MASLD); Wilson’ s disease; hemochromatosis; liver cancer

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights into Virus-Host Immune Interactions

edited by

Claudia Vanetti

submission deadline 20 Dec 2025 | 1 articles | Viewed by 628 | Submission Open

Keywords: viral diseases; virus– host interactions; vaccination; interferon signalling; antibody responses; viral proteins; SARS-CoV-2

(This special issue belongs to the Section Molecular Immunology)

RNA Editing/Modification in Health and Disease

edited by Valeriana Cesarini and

Piergiorgio La Rosa

submission deadline 20 Dec 2025 | 1 articles | Viewed by 607 | Submission Open

Keywords: RNA editing; RNA transport and localization; miRNAs; siRNAs; lncRNAs

(This special issue belongs to the Section Molecular Genetics and Genomics)

Latest Molecular Research on Polymer Coatings

edited by

Joanna Karasiewicz

submission deadline 20 Dec 2025 | 1 articles | Viewed by 595 | Submission Open

Keywords: synthesis of specialty compounds; specialty compounds in industrial treatment; amphiphilic compounds; wettability (including solids and biomaterials); antimicrobial activity; surface activity; superwetting; high hydrophobic/hydrophilic/olrophobic/olephilic properties; special applications: self-cleaning; anti-icing; self-healing; biocidal; etc.

(This special issue belongs to the Section Materials Science)

Physiological and Pathophysiological Aspects of Intracellular and Extracellular Modulator Proteases

edited by

Takuro Miyazaki

submission deadline 20 Dec 2025 | 1 articles | Viewed by 593 | Submission Open

Keywords: a disintegrin and metalloproteinase domain-containing protein; calpain; ectoproteinase; inflammasome; secretase

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Age-Related Cognitive Decline

edited by

Cristovam Wanderley Picanço Diniz

submission deadline 20 Dec 2025 | Viewed by 584 | Submission Open

Keywords: cognitive decline; molecular mechanisms; aging individuals; therapeutic targets; neuroinflammation; oxidative stress; protein aggregation; vascular changes

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Esophageal Inflammation, Injury, and Repair

edited by Anisa Shaker

submission deadline 20 Dec 2025 | 1 articles | Viewed by 581 | Submission Open

Keywords: GERD; eosinophilic esophagitis; achalasia; esophageal cancer; barrett’ s esophagus; microbiome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Cancer Stem Cells

edited by

Sabrina Battista

submission deadline 20 Dec 2025 | Viewed by 563 | Submission Open

Keywords: self-renewal; microenvironment; plasticity; epigenetics; epithelial-mesenchymal transition; heterogeneity; targeting; dormancy

(This special issue belongs to the Section Biochemistry)

Advances in the Pathogenesis of Allergic Diseases: From Mechanisms to Therapeutics

edited by Clinton B. Mathias and Michiko K. Oyoshi

submission deadline 20 Dec 2025 | 1 articles | Viewed by 545 | Submission Open

Keywords: food allergy; allergic mechanisms; asthma; allergic disease; mast cells; ILC2s; Th2 cells; eosinophils; IL-4; IL-33; IL-13

(This special issue belongs to the Section Molecular Immunology)

Innovative Approaches in Organic Synthesis and Functional Materials: From Design to Biological Impact

edited by

Antonio Rescifina

and

Chiara Zagni

submission deadline 20 Dec 2025 | 1 articles | Viewed by 544 | Submission Open

Keywords: organic synthesis; bioactive molecules; functional materials; molecular informatics; biological activity; molecular docking; computational chemistry; drug design; medicinal chemistry; quantitative structure– activity relationships (QSARs); environmental applications; sustainable chemistry; natural products

(This special issue belongs to the Section Molecular Informatics)

Rethinking Fat: A Deeper Dive into the Diversity and Dynamic Roles of Adipose Tissue

edited by

Ahmed Bettaieb

submission deadline 20 Dec 2025 | Viewed by 535 | Submission Open

Keywords: adipose tissue biology; stem cell commitment and differentiation; thermogenic adipocytes; genetic regulation; metabolic homeostasis; selective targeting

(This special issue belongs to the Section Molecular Biology)

DNA Virus Infection: HPV-Related Cancers, Pathology, Biomarkers and Immunotherapy

edited by

Dimitris Tsakogiannis

submission deadline 20 Dec 2025 | Viewed by 530 | Submission Open

Keywords: HPV; molecular diagnostics; HPV ctDNA; cancer; mutations; viral oncogenicity; immunotherapy; biomarkers; oncology; cancer treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Trends in the Research of Molecules Involved in Skin Inflammation and Dermatologic Conditions

edited by

Liborija Lugovic-Mihic

submission deadline 20 Dec 2025 | 1 articles | Viewed by 523 | Submission Open

Keywords: atopic dermatitis; contact dermatitis; psoriasis; urticaria; eczema; acne; rosacea; seborrheic dermatitis; drug-induced reaction; prurigo nodularis; lichen; hidradenitis suppurativa; alopecia; chronic urticaria; skin tumor; angioedema; venous ulcer; HPV skin manifestations; skin infection; vitiligo

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathophysiology of Hair Loss

edited by

Kwang-Hyun Park

submission deadline 20 Dec 2025 | Viewed by 508 | Submission Open

Keywords: Hair Loss; Pathophysiology; Molecular Mechanisms; Genetic Mutations; Signaling Pathways; Nutrient Interactions; Personalized Therapies; Targeted Drug Delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 2801-2850 on page 57 of 70.

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