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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Toxicology of Cyanobacterial Toxins
edited by
submission deadline 30 Nov 2026 | Viewed by 206 | Submission Open
Keywords: toxicology; cyanotoxins; cyanobacteria; harmful effects; health risk
(This special issue belongs to the Section Molecular Toxicology)
Bioactive Food Ingredients and Precision Nutrition: From Molecular Innovation to Clinical Relevance
edited by Lídia Pinheiro and
submission deadline 30 Nov 2026 | 1 articles | Viewed by 202 | Submission Open
Keywords: bioactive food ingredients; functional foods; nutraceuticals; precision nutrition; gut microbiota; delivery systems; omics technologies; AI in nutrition; personalized nutrition; immune modulation; neuroprotection
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Design, Synthesis, and Application of Functional Porous Materials
edited by Qinhe Pan, and
submission deadline 30 Nov 2026 | Viewed by 200 | Submission Open
Keywords: porous materials; functional guest species; functionalization; luminescence; electrochemistry; stimulus response; adsorption; sensing; photoelectric; catalysis
(This special issue belongs to the Section Materials Science)
Design, Synthesis and Development of Anticancer Drugs Targeting the Tumor Microenvironment
edited by
submission deadline 30 Nov 2026 | Viewed by 197 | Submission Open
Keywords: anticancer drugs; tumor microenvironment; in vivo model; cancer-associated fibroblast; tumor-associated macrophage; tumor hypoxia; tumor endothelial cells
(This special issue belongs to the Section Molecular Oncology)
Plant Natural Products: New Advances in the Discovery, Regulation, and Engineering submission deadline 30 Nov 2026 | Viewed by 195 | Submission Open
Keywords: polyphenols; glycoconjugates; plant protein; polysaccharides; crop production; processing wastes; circular economy; techno-economical evaluation
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms of Adipose Tissue Dysfunction
edited by
submission deadline 30 Nov 2026 | Viewed by 192 | Submission Open
Keywords: adipose tissue dysfunction; adipogenesis; immunometabolism and adipokines; mitochondrial dysfunction; extracellular vesicles; fibrosis and ECM remodeling; lipid metabolism; browning and beigeing; metabolic biomarkers and therapeutic targets; adipose-derived stem cells
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Smart and Sustainable Hydrogels for Environmental Applications
edited by Rolando Chamy
submission deadline 30 Nov 2026 | Viewed by 184 | Submission Open
Keywords: hydrogel; biomaterials; sustainable materials; regenerative medicine
(This special issue belongs to the Section Materials Science)
Molecular Interactions Between Bacteria and Viruses: Mechanisms and Pathogenic Insights
edited by Vasilis Petrakis
submission deadline 30 Nov 2026 | Viewed by 183 | Submission Open
Keywords: viral infections; HIV/AIDS; SARS-CoV-2; antibiotics; antimicrobial resistance; antiviral agents
(This special issue belongs to the Section Molecular Microbiology)
Next-Generation Sequencing Assays in Precision Oncology
edited by Kakoli Das, and Chuah Khoon Leong
submission deadline 30 Nov 2026 | Viewed by 180 | Submission Open
Keywords: precision oncology; NGS; genomics; transcriptomics; proteomics; molecular pathology; multi-omics integration
(This special issue belongs to the Section Molecular Oncology)
Pathogenesis of Pathogenic Fungi: The Era of AI and New Technologies
edited by
submission deadline 30 Nov 2026 | Viewed by 179 | Submission Open
Keywords: artificial intelligence; molecular diagnosis and detection; therapeutic targeting; resistance and prediction; host relationships; immunity
(This special issue belongs to the Section Molecular Microbiology)
Molecular Research on Foodborne Pathogens and Biofilms submission deadline 30 Nov 2026 | Viewed by 174 | Submission Open
Keywords: foodborne pathogens; biofilms; food
(This special issue belongs to the Section Molecular Microbiology)
Deep Learning Biomarkers for Cancer Therapy
edited by
submission deadline 30 Nov 2026 | Viewed by 174 | Submission Open
Keywords: deep learning; cancer biomarkers; precision oncology; histopathology; medical imaging; explainable AI; cancer detection; cancer segmentation; digital pathology; clinical decision support
(This special issue belongs to the Section Molecular Oncology)
Molecular Crosstalk Between Allergens, Microbes, and the Mucosal Immune System
edited by Stefanie Gilles
submission deadline 30 Nov 2026 | Viewed by 172 | Submission Open
Keywords: allergens and innate immunity; mucosal immune signaling; epithelial barrier and inflammation; pathogen-allergen crosstalk; bioaerosol exposure; allergen recognition mechanisms; environmental immunology
(This special issue belongs to the Section Molecular Immunology)
Bioactive Peptides from Natural Sources: Pharmacological Effects, Recombinant Expression, Modification, Molecular Mechanisms, and Therapeutic Potential
edited by Linchun Shi
submission deadline 30 Nov 2026 | Viewed by 169 | Submission Open
Keywords: bioactive peptides; functional peptides; antimicrobial peptides; host-defense peptides; venom peptides; ribosomally synthesized and post-translationally modified peptides; peptide precursor gene families; comparative genomics; phylogeny; structure– activity relationship
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Newest Antibacterial Applications of Metal Nanoparticles
edited by
submission deadline 30 Nov 2026 | Viewed by 165 | Submission Open
Keywords: metal oxides; hydroxyapatites; antibacterial; gram positive; gram negative; nanoparticles; antibacterial; antibacterial resistance; bioactivity; biocompatibility; metal-based nanoparticles
(This special issue belongs to the Section Molecular Nanoscience)
Trace Elements in Nutrition and Health Research submission deadline 30 Nov 2026 | Viewed by 161 | Submission Open
Keywords: trace elements; essential elements; toxic trace elements; micronutrient homeostasis; bioavailability; nutrient interactions; deficiency and overload; human health; disease prevention
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Pharmacology and Biological Activities of Natural and Derivatives Bioactive Compounds submission deadline 30 Nov 2026 | Viewed by 157 | Submission Open
Keywords: molecular pharmacology; therapeutic potential; natural compounds; synthetic derivatives of natural compounds; biological activity; mechanism of action; molecular docking; anticancer; antimicrobial; pharmacokinetics; pharmacodynamics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Ferroptosis: Mechanisms and Roles in Diseases
edited by Yuquan Chen
submission deadline 30 Nov 2026 | Viewed by 156 | Submission Open
Keywords: ferroptosis; iron metabolism; lipid peroxidation; oxidative stress; endocrine diseases; metabolic disorders; environmental exposures; circadian rhythm; redox signaling; cell death
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Encephalitis: Mechanisms, Models, and Treatment Strategies submission deadline 30 Nov 2026 | Viewed by 154 | Submission Open
Keywords: encephalitis; neuroinflammation; host– pathogen interactions; central nervous system; experimental models; comparative medicine; veterinary medicine; human medicine; molecular mechanisms; treatment strategies
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Pharmacognosy and Phytochemical Profiling in Natural Product Research
edited by Kamran Ashraf
submission deadline 30 Nov 2026 | Viewed by 153 | Submission Open
Keywords: molecular pharmacognosy; phytochemical profiling; natural products; bioactive compounds; metabolomics; chemometrics; LC– MS/MS; GC– MS; molecular mechanisms; drug discovery
(This special issue belongs to the Section Molecular Plant Sciences)
Current Research in DNA Methylation
edited by Mikhail M. Baryshev
submission deadline 30 Nov 2026 | Viewed by 153 | Submission Open
Keywords: DNA methylation; cancer-specific DNA methylation; epigenetics; lncRNA; CpG; CHG; CHH; CCWGG methylation types; chromatin remodeling
(This special issue belongs to the Section Biochemistry)
Interaction Between Gut Microbiota and Food Bioactive Compounds
edited by
submission deadline 30 Nov 2026 | Viewed by 150 | Submission Open
Keywords: gut microbiota; bioactive compounds; microbial metabolites; host– microbe interactions; molecular mechanisms; host signaling pathways; nutritional intervention; gut– diet– health axis; microbiota modulation; metagenomic/metatransxriptomics; prebiotics/probiotics/synbiotics; intestinal barrier function
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Research on Molecular Mechanisms of Food Quality Regulation
edited by Jun Yan
submission deadline 30 Nov 2026 | Viewed by 147 | Submission Open
Keywords: food quality regulation; molecular mechanism; omics technology; food macromolecules; postharvest preservation; gene transcription regulation
(This special issue belongs to the Section Molecular Biology)
Latest Research on Mixed Biofilms: Bacterial and Antimicrobial submission deadline 30 Nov 2026 | Viewed by 147 | Submission Open
Keywords: antimicrobial resistance (AMR); biofilms; mixed-species biofilms; microbial interactions; anti-biofilm strategies; microbial virulence; host– pathogen interactions; microbiome; omics approaches (proteomics; genomics; metabolomics); infectious diseases
(This special issue belongs to the Section Molecular Microbiology)
Mesenchymal Stem Cells: Evolving Concepts and Their Functions in Regeneration and Repair Processes
edited by Rodrigo Somoza
submission deadline 30 Nov 2026 | Viewed by 145 | Submission Open
Keywords: mesenchymal stem cells; medicinal signaling cells; pericytes; immunomodulation; paracrine signaling; regenerative medicine; perivascular niche; extracellular vesicles; allogeneic cell therapy
(This special issue belongs to the Section Molecular Biology)
Molecular Insights Through Bioinformatics and Machine Learning: Precision-Driven Discovery of Drugs, Nutraceuticals, and Insecticides submission deadline 30 Nov 2026 | Viewed by 131 | Submission Open
Keywords: computational bioactive compound discovery; density functional theory (DFT); antioxidant mechanisms; natural product-based drug discovery; AI-driven molecular modeling
(This special issue belongs to the Section Molecular Informatics)
Molecular Advances in the Diagnosis and Treatment of Cardiovascular Disease and Diabetes Mellitus
edited by Ovidiu Nicolae Pop and
submission deadline 30 Nov 2026 | Viewed by 127 | Submission Open
Keywords: cardiovascular disease; diabetes mellitus; molecular medicine; precision medicine; cardiometabolic disease; biomarkers; inflammation; oxidative stress; epigenetics; non-coding rna; sglt2 inhibitors; glp-1 receptor agonists; gene therapy; regenerative medicine; translational therapeutics; personalized medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Transcription Factors in Plant Gene Expression Regulation, 3rd Edition
edited by
submission deadline 30 Nov 2026 | Viewed by 120 | Submission Open
Keywords: plant trans-factor  ; cis-active sequence  ; post-translational modification  ; dimerization and oligomerization  ; DNA modules
(This special issue belongs to the Section Molecular Plant Sciences)
Natural Bioactives Targeting Molecular Mechanisms in Neurological Disorders: From Pathophysiology to Therapy
edited by Jinatta Jittiwat
submission deadline 30 Nov 2026 | Viewed by 117 | Submission Open
Keywords: natural bioactives; molecular mechanisms; neurological disorders; oxidative stress; neuroinflammation; therapeutic targeting; neuroprotection; mitochondrial dysfunction; apoptosis
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms of Nerve Injury and Regeneration
edited by Barbara Hausott
submission deadline 30 Nov 2026 | Viewed by 116 | Submission Open
Keywords: nerve injury; regeneration; sensory neuron; motoneuron; Schwann cell; macrophage; neutrophin; cytokine; transcription factor; microrna
(This special issue belongs to the Section Molecular Neurobiology)
Plant Reproductive Genetics and Genomics in Crop Breeding submission deadline 30 Nov 2026 | Viewed by 113 | Submission Open
Keywords: genetics; heredity; agronomy; maize breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Plant Viruses: Discovery and Genetic Diversity
edited by
submission deadline 30 Nov 2026 | Viewed by 111 | Submission Open
Keywords: novel virus; discovery; high-throughput sequencing; diversity; population geneticss; evolutionary dynamic
(This special issue belongs to the Section Molecular Plant Sciences)
Plant–Microbe Interactions Driving Abiotic Stress Adaptation
edited by Saeed Ur Rahman and Nan Hui
submission deadline 30 Nov 2026 | Viewed by 107 | Submission Open
Keywords: plant– microbe interactions; abiotic stress; rhizosphere microbiome; stress tolerance; horticultural crops; molecular mechanisms; plant growth-promoting microbes; omics approaches; sustainable agriculture; signaling pathways
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular and Cellular Mechanisms in Fibrotic Interstitial Lung Diseases
edited by Eirini Vasarmidi
submission deadline 30 Nov 2026 | Viewed by 100 | Submission Open
Keywords: interstitial lung diseases; rare lung diseases; autoimmune lung diseases; pulmonary fibrosis; molecular pathways; biomarkers; bronchoalveolar lavage; genetics in lung fibrosis; familial fibrosis; pathogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Translational Pharmacogenomics and Precision Medicine: From Discovery to Application
edited by
submission deadline 30 Nov 2026 | Viewed by 100 | Submission Open
Keywords: pharmacogenomics; personalized medicine; drug discovery; cancer genetics; wellness; nutrigenomics; mindfulness; genome; health; dentistry; education; microbiome
(This special issue belongs to the Section Molecular Genetics and Genomics)
Bioinformatics and Phylogenetics of Molecular Pathways and Human Diseases
edited by
submission deadline 30 Nov 2026 | Viewed by 99 | Submission Open
Keywords: bioinformatics; phylogenetics; molecular pathways; human disease; multi-omics integration; biomarker discovery; disease knowledge graph
(This special issue belongs to the Section Molecular Informatics)
Regulatory Networks and Gene Expression Pathways in Bacteria
edited by Miguel A. Ares
submission deadline 30 Nov 2026 | Viewed by 98 | Submission Open
Keywords: bacterial gene expression; regulatory networks; transcription factors; sigma factors; two-component systems; quorum sensing; non-coding RNAs; host– pathogen interactions; bacterial adaptation; RNA-seq
(This special issue belongs to the Section Molecular Microbiology)
The Balance of the Microbiome and Human Health: A Molecular Perspective
edited by
submission deadline 30 Nov 2026 | Viewed by 95 | Submission Open
Keywords: host– microbiome interactions; molecular mechanisms; metabolite signaling; multi-omics integration; genome-scale metabolic models (GEMs); machine learning; spatial microbiome; precision intervention; microbiome– drug interaction; personalized nutrition
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms of Neuropsychiatric Disorders
edited by Marina Mitrovic, and
submission deadline 30 Nov 2026 | Viewed by 95 | Submission Open
Keywords: neurological disorders; psychiatric disorders; pathophysiological mechanisms; apoptosis; oxidative stress; inflammation; neurotransmitters; neurotrophins; pharmacotherapy; transcranial stimulation
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insights in Cardiovascular Disease
edited by
submission deadline 30 Nov 2026 | Viewed by 89 | Submission Open
Keywords: heart failure; gut microbiome dysbiosis-cardiotoxicity; diabetic cardiomyopathy; cardiovascular aging; chemotherapy associated cardiotoxicity; autophagy; mitochondrial dysfunction; rhythmic disorders; risk factors; ion channels; energy metabolism; cardiac hypertension; echocardiography; remodelling; transplantation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Diagnosis and Treatments of Diabetes Mellitus: 3rd Edition submission deadline 30 Nov 2026 | Viewed by 89 | Submission Open
Keywords: metabolic disorders; diabetes mellitus; inflammation; neurotransmitter; inflammatory biomarkers; molecular target; molecular diagnostics; therapeutics; insulin resistance
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Vascular Calcification: Molecular Regulation, Inflammation and Translational Perspectives
edited by
submission deadline 30 Nov 2026 | Viewed by 89 | Submission Open
Keywords: vascular calcification; inflammation; calcium-phosphate alterations; osteogenic differentiation; vascular smooth muscle cells; cardiovascular disease
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Addiction and Substance Abuse Disorders
edited by Martin O. Job
submission deadline 30 Nov 2026 | Viewed by 85 | Submission Open
Keywords: psychostimulant use disorders; opioid use disorders; addiction; biomarkers; phenotypes; heterogeneity; genomics; epigenetics; metabolomics; translational research
(This special issue belongs to the Section Molecular Neurobiology)
Abiotic Stresses in Plants: An Update
edited by Krzysztof Michał Tokarz
submission deadline 30 Nov 2026 | Viewed by 82 | Submission Open
Keywords: extreme temperatures; floods; photosynthetic apparatus; salinity; secondary metabolites; UV radiation; water shortages
(This special issue belongs to the Section Molecular Plant Sciences)
Cyclodextrins: Properties and Applications, 4th Edition submission deadline 30 Nov 2026 | Viewed by 82 | Submission Open
Keywords: cyclodextrins; controlled release systems; structure modification; thermodynamic properties; transport properties
(This special issue belongs to the Section Macromolecules)
New Insights into Immune Dysregulation Disorders: Second Edition
edited by
submission deadline 30 Nov 2026 | Viewed by 80 | Submission Open
Keywords: immune dysregulation disorders; autoimmune conditions; primary immunodeficiencies; autoinflammatory disorders
(This special issue belongs to the Section Molecular Immunology)
Metabolomics in Functional Foods and Nutritional Health submission deadline 30 Nov 2026 | Viewed by 79 | Submission Open
Keywords: metabolomics; functional foods; bioactive compounds; nutritional health; systems biology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
State-of-the-Art Molecular Pharmacology in Thailand submission deadline 30 Nov 2026 | Viewed by 78 | Submission Open
Keywords: molecular pharmacology; pharmacogenomics; bioactive natural products; drug discovery and design; molecular targets; precision medicine; signal transduction; cholangiocarcinoma therapeutics; neuropharmacology
(This special issue belongs to the Section Molecular Pharmacology)
Research Advances in Vegetable Breeding and Genetics
edited by
submission deadline 30 Nov 2026 | Viewed by 78 | Submission Open
Keywords: vegetable; breeding; genetics; genomics; gene editing; marker-assisted selection; stress resistance; quality improvement; crop improvement; horticulture  
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Pharmacogenomics and Drug Repositioning submission deadline 30 Nov 2026 | Viewed by 77 | Submission Open
Keywords: risk prediction; gene– drug interactions; genetic polymorphisms; repurposed drugs; integrative analytics; variant mapping; predictive modeling; molecular docking; cheminformatics; genotype-guided therapy; real-world evidence
(This special issue belongs to the Section Molecular Pharmacology)
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