New Advance in Xenobiotic Toxicology
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".
Deadline for manuscript submissions: 30 April 2026
Special Issue Editor
Special Issue Information
Dear Colleagues,
Understanding xenobiotic toxicity has become increasingly critical as humans and ecosystems are continuously exposed to a growing diversity of synthetic and naturally occurring chemical compounds. Xenobiotics—including pharmaceuticals, environmental pollutants, industrial chemicals, food additives, and botanical toxins—interact with cellular pathways in ways that can profoundly influence metabolic homeostasis, inflammation, oxidative stress, and long-term disease risk. Recent scientific advances have revealed complex mechanisms of xenobiotic biotransformation, the role of genetic and epigenetic factors in modulating susceptibility, and the impact of chronic low-dose exposure on human health. At the same time, innovations in high-throughput screening, omics-based approaches, and advanced in vitro models such as organoids and microphysiological systems have expanded our ability to detect and characterize toxic effects with greater precision. Given the increasing global concern over environmental contamination, emerging pollutants, and the safety of consumer products, advancing our understanding of xenobiotic toxicity is essential for improving risk assessment, informing regulatory decisions, and guiding the development of safer chemicals and therapeutic strategies.
We are pleased to invite you to contribute to this Special Issue which will focus on recent studies investigating xenobiotic toxicity, with particular emphasis on elucidating the molecular mechanisms using new approaches such as high-throughput screening, omics-based approaches, advanced in vitro models, new approach methodologies (NAMs), in vivo alternative models, among others. Despite increasing concern about human and environmental exposure to xenobiotics, for many compounds there remains limited knowledge regarding their molecular targets. Studies that clarify these interactions are, therefore, essential and highly encouraged, as they provide critical insights into the mechanisms of toxicity, inform risk assessment, and support the development of safer chemicals and therapeutic strategies.
In this Special Issue, original research articles, case-reports, and reviews are welcome.
Dr. Marcelo Arbo
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- xenobiotics
- toxicity tests
- biotransformation
- drug effects
- signal transduction
- environmental pollutants
- chemically induced- injury
- toxicogenomics
- biomarkers
- risk assessment
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