Skeletal Muscle Aging: Mechanisms, Biomarkers, and Interventions
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 March 2026
Special Issue Editor
Interests: exercise; aging; whole body vibration; musculoskeletal diseases; osteoporosis; sarcopenia; neurodegeneration; quality of life
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Skeletal muscle aging is a complex and multifactorial process characterized by progressive atrophy, reduced contractile function, and impaired metabolic plasticity, ultimately leading to sarcopenia and frailty. The molecular hallmarks of aged muscle include mitochondrial dysfunction, increased reactive oxygen species production, chronic low-grade inflammation, and altered satellite cell dynamics. Recent advances in molecular biology have identified novel pathways governing mitochondrial quality control, protein homeostasis, and inflammatory signalling in aged skeletal muscle. However, numerous determinants involved in muscle aging remain unknown, highlighting the need to further investigate the molecular mechanisms underlying skeletal muscle aging. This Special Issue of the International Journal of Molecular Sciences gathers original research articles and reviews that dissect the molecular determinants of skeletal muscle aging, with the aim of identifying mechanistic insights and therapeutic strategies to preserve muscle function across the lifespan.
Dr. Ida Cariati
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- • skeletal muscle aging • sarcopenia • muscle metabolism • mitochondrial dysfunction • inflammation • exercise adaptation • muscle adaptation
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