Current Research on Autophagy in Aging and Age Related Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 20 November 2026 | Viewed by 2014
Editor
Special Issue Information
Dear Colleagues,
Aging is one of the greatest biological challenges with far-reaching social and economic consequences. As life expectancy increases, so does the prevalence of age-related diseases such as cancer, Alzheimer's disease, cardiovascular disorders, and diabetes. Understanding the molecular mechanisms of aging paves the way for targeted therapies and strategies to extend healthspan.
Aging results from a complex interplay of molecular processes, including DNA damage, epigenetic modifications, telomere attrition, and cumulative cellular stress. Among the key protective mechanisms, autophagy plays a critical role in maintaining cellular homeostasis by eliminating defective mitochondria, misfolded proteins, and toxic aggregates. This tightly regulated self-degradative process enhances stress resistance and supports longevity, whereas its dysregulation accelerates aging and contributes to disease.
In this Special Issue of IJMS we focus on recent advances in understanding the role of autophagy in aging and its impact on age-related diseases. Suitable topics include, but are not limited to, contributions that explore underlying mechanisms, potential therapeutic interventions, and broader implications for promoting longevity and healthy aging.
Dr. Tímea Sigmond
Guest Editor
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Keywords
- autophagy
- aging
- molecular mechanisms
- age related diseases
- mitochondria
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