Advances in Sepsis: Molecular and Biochemical Perspectives
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 115
Special Issue Editor
Interests: neutrophils/NETs; immunity; inflammation; thrombosis; fibrosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Sepsis stands out among critical conditions in contemporary clinical practice as a multifaceted challenge marked by a dysregulated host response to infection that can lead to organ dysfunction and mortality. The mechanisms underlying sepsis involve complex interactions between pathogens, immune cells, inflammatory mediators, and alterations in the microbiome, making the understanding of its pathophysiology imperative for effective management. As the interplay of these biological components varies widely from patient to patient, recognizing sepsis’s heterogeneity is crucial for tailoring therapeutic strategies. Traditional molecular and biochemical diagnostic approaches could delay appropriate treatment initiation.
There is still an urgent need to diagnose, stratify, and monitor sepsis early in order to develop novel and improved molecular diagnostic and biochemical techniques for gene expression, epigenetic modifications, proteomic and metabolic signatures, and machine learning algorithms, which may uncover features that offer novel insights into understanding immune dysfunctions.
These approaches will provide hope of discovering new biomarkers for the development of future therapies and, moreover, underline personalized therapeutic approaches in managing sepsis, because the traditional one-size-fits-all approach to sepsis management is increasingly deemed insufficient considering each individual patient’s inflammatory and immune status (different phenotype), such as their sepsis inflammatory endotype classification.
This Special Issue is Guest Edited by Dr. Akrivi Chrysanthopoulou, assisted by Dr. Asimina Safarika and Dr. Spyros Foutadakis (Hellenic Institute for the Study of Sepsis). We welcome original research manuscripts and review articles on the development of better diagnostic tools offering novel insights into the development of new therapeutic strategies in sepsis to improve the survival and quality of life of patients affected by this life-threatening condition.
Dr. Akrivi Chrysanthopoulou
Guest Editor
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Keywords
- sepsis
- outcome
- molecular diagnosis
- machine learning
- biochemical biomarkers
- targeted immunotherapy
- personalized medicine
- sepsis inflammatory endotypes
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