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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Insights of Metabolomics
edited by
submission deadline 31 Oct 2026 | Viewed by 105 | Submission Open
Keywords: pathway; metabolites; metabolomics; LC; GC; NMR; mechanism; statistical analysis
(This special issue belongs to the Section Biochemistry)
Molecular Biomarkers and AI in Cardiac Electrophysiology
edited by Kenneth C. Bilchick
submission deadline 31 Oct 2026 | Viewed by 103 | Submission Open
Keywords: cardiac electrophysiology; molecular biomarkers; artificial intelligence; machine learning; atrial fibrillation; ventricular arrhythmia; sudden cardiac death; electrocardiography (ECG); cardiac imaging; precision medicine
(This special issue belongs to the Section Molecular Biology)
T Cells in Cancer: From Effectors to Regulators and Therapeutic Targeting
edited by
submission deadline 31 Oct 2026 | Viewed by 103 | Submission Open
Keywords: T-cell in cancer; tumor microenvironment (TME); T cell exhaustion; oncogenic signaling pathways; cancer immunotherapy; immunometabolism
(This special issue belongs to the Section Molecular Immunology)
Metal Complexes: From Synthesis to Pharmacological Studies and Application
edited by Joksimović Nenad and
submission deadline 31 Oct 2026 | Viewed by 102 | Submission Open
Keywords: metal complexes; medicinal inorganic chemistry; bioactive ligands; pharmacological activity; molecular docking; biomolecular interactions; anticancer agents; antimicrobial activity; coordination chemistry; structure– activity relationship
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Insights into Cancer Biomarkers and Targeted Therapies in Solid Tumors
edited by Michele Ghidini
submission deadline 31 Oct 2026 | Viewed by 101 | Submission Open
Keywords: cancer biomarkers; target therapies; solid tumors; mutations; molecular biology; immunotherapy; TKI inhibitors; monoclonal antibodies; NGS; molecular panel
(This special issue belongs to the Section Molecular Oncology)
The Microbiome: Bridging Human Health and Natural Ecosystems
edited by
submission deadline 31 Oct 2026 | Viewed by 97 | Submission Open
Keywords: microbiome; human health; natural ecosystems; gut microbiome; environmental microbiomes; gut– brain axis; soil microbiome; 16S sequencing; aquatic microbiome; climate change; One Health; probiotics; metagenomics; microbial diversity; therapeutic interventions
(This special issue belongs to the Section Molecular Microbiology)
Antibody-Based Therapeutics for Autoimmune Diseases
edited by
submission deadline 31 Oct 2026 | Viewed by 97 | Submission Open
Keywords: autoimmune diseases; antibody-based therapeutics; autoantibodies; immunotherapy; precision medicine
(This special issue belongs to the Section Molecular Immunology)
Toward an Integrated Understanding of Circadian and Neuroendocrine Interactions in Health and Disease submission deadline 31 Oct 2026 | Viewed by 97 | Submission Open
Keywords: chronobiology; circadian system; neuroendocrine system; multidirectional crosstalk; neurons; endocrine cells; endocrine regulation; zeitgebers; hormones; neurotransmitters; homeostasis; diseases
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
New Insights into Gastroesophageal Tumors
edited by and Luisa Foltran
submission deadline 31 Oct 2026 | Viewed by 96 | Submission Open
Keywords: gastric cancer; esophageal cancer; biomarkers; target therapy; immunotherapy; NGS
(This special issue belongs to the Section Molecular Oncology)
Progress in Functional Genomics and Regulation of Gene Expression
edited by Alejandro Bravo-Patino
submission deadline 31 Oct 2026 | Viewed by 94 | Submission Open
Keywords: functional genomic; gene regulation; gene interactions; biomarkers; differential gene expression; epigenetics and gene regulation
(This special issue belongs to the Section Molecular Genetics and Genomics)
Heart Diseases: Molecular Research and Novel Therapies
edited by Monika M. Gladka
submission deadline 31 Oct 2026 | Viewed by 93 | Submission Open
Keywords: cardiovascular diseases; molecular mechanisms; cardiac remodeling; heart failure; gene regulation; epigenetics; non-coding RNA; inflammation; regenerative medicine; novel therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Overcoming Membrane Protein Challenges with Computational Methods
edited by
submission deadline 31 Oct 2026 | Viewed by 93 | Submission Open
Keywords: membrane protein; structural and functional properties; computational approaches; molecular dynamics; free energy calculations; computational docking and drug design approaches
(This special issue belongs to the Section Macromolecules)
Ion Channels and Transporters: Regulation and Roles in Human Diseases
edited by
submission deadline 31 Oct 2026 | Viewed by 92 | Submission Open
Keywords: Ca2+/K+/Na+/Cl-  channels/transporters; organelle ion channels/transporters; Mg2+/ Zn2+/Mn2+  transporters; disease microenvironment; membrane trafficking; transcriptional regulation; post-translational regulation; epigenetic modification; protein degradation
(This special issue belongs to the Section Biochemistry)
High Fat Diet Metabolism and Diseases: 2nd Edition submission deadline 31 Oct 2026 | Viewed by 92 | Submission Open
Keywords: diet; fat; high-fat diets; obesity; NAFLD; metabolism; reproductive system; lungs; pathology
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Drug Toxicity and Its Impact on Disease Therapies
edited by Metoda Lipnik-Štangelj
submission deadline 31 Oct 2026 | Viewed by 91 | Submission Open
Keywords: computational methods; toxicity prediction; pharmacogenomics; molecular mechanisms; drug-induced toxicity; adverse drug effects; organ toxicity; polypharmacy
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Immunology and Defenses: Oral and Periodontal Health
edited by Evangelos Papathanasiou
submission deadline 31 Oct 2026 | Viewed by 91 | Submission Open
Keywords: periodontal disease; immune response; host defense; inflammation; immune regulation
(This special issue belongs to the Section Molecular Immunology)
Exercise and Immunopathology
edited by Rodolfo de Paula Vieira and Luis Vicente Franco Oliveira
submission deadline 31 Oct 2026 | Viewed by 89 | Submission Open
Keywords: exercise immunology; exercise physiology; inflammation; immune response; cardiopulmonary diseases; exercise rehabilitation; immune modulation; chronic diseases; aging and exercise; sports physiology
(This special issue belongs to the Section Molecular Immunology)
Adrenal Endocrinology: Molecular Insights and Emerging Trends
edited by , and Francesco Circosta
submission deadline 31 Oct 2026 | Viewed by 89 | Submission Open
Keywords: adrenal disorders; steroid profiling; multi-omics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
The Role of Protein Kinase in Health and Diseases, 2nd Edition
edited by
submission deadline 31 Oct 2026 | Viewed by 86 | Submission Open
Keywords: protein kinases; phosphorylation; cancer; neurological disorder; targeted therapies; meta-bolic diseases
(This special issue belongs to the Section Molecular Biology)
Biochemical Functions and Therapeutic Potential of Dietary Bioactive Peptides
edited by
submission deadline 31 Oct 2026 | Viewed by 85 | Submission Open
Keywords: bioactive peptides; molecular mechanisms; structure– activity relationship; peptidomics; functional foods; by-product valorization; antioxidant activity; bioavailability; cellular signaling; multidisciplinary approaches
(This special issue belongs to the Section Biochemistry)
Recent Advances in Therapeutic Targets for Musculoskeletal Tumors
edited by Japneet Kaur
submission deadline 31 Oct 2026 | Viewed by 84 | Submission Open
Keywords: musculoskeletal tumors; sarcoma; bone metastasis; tumor microenvironment; targeted therapy; immunotherapy; biomarkers; drug resistance; signaling pathways; cancer biology
(This special issue belongs to the Section Molecular Oncology)
Effects of Oxidative Stress and Mitochondrial Function on Lifespan
edited by Ines Sanchez-Roman
submission deadline 31 Oct 2026 | Viewed by 83 | Submission Open
Keywords: aging; mitochondrial dysfunction; oxidative stress; genomic instability; longevity; aging-associated diseases; interventions; reactive oxygen species
(This special issue belongs to the Section Molecular Biology)
Spatial Multi-Omics: From Molecular Maps to Precision Medicine
edited by
submission deadline 31 Oct 2026 | Viewed by 83 | Submission Open
Keywords: multi-omics; spatial multi-omics; cell-type-specific molecular alterations; tissue microenvironments; molecular diagnostics; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Molecular Biomaterials for Pollutants Removal
edited by Jarosław Chwastowski and
submission deadline 31 Oct 2026 | Viewed by 82 | Submission Open
Keywords: biomaterials; biosorption; biodegradation; microorganisms; isotherm and kinetic modeling; organic sorbents
(This special issue belongs to the Section Materials Science)
Pathophysiology and Treatments of Spinal Cord Injury
edited by Roxana Rodríguez-Barrera and Elisa García-Vences
submission deadline 31 Oct 2026 | Viewed by 80 | Submission Open
Keywords: spinal cord injury; treatments; therapy cell; neuromodulation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Signaling Pathways Dysregulation in Cancer: Advances and New Therapeutics Hopes: 2nd Edition
edited by
submission deadline 31 Oct 2026 | Viewed by 79 | Submission Open
Keywords: cancer; epithelial cells; oncogenic mutations; PI3K/AKT/mTOR; TGF-β ; Ras/Raf/MEK/ERK; Wnt/β -catenin; angiogenesis; invasion; metastasis; inhibitors
(This special issue belongs to the Section Molecular Oncology)
Nutrient Sensing in Human Metabolic Disorders
edited by
submission deadline 31 Oct 2026 | Viewed by 79 | Submission Open
Keywords: nutrient sensing; obesity; insulin resistance; type 2 diabetes; metabolic disease; adipokines; AMPK; mTOR; inflammation; oxidative stress
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Acute Lymphoblastic Leukemia (ALL): From Molecular Drivers to Therapeutic Innovation
edited by Carmen Maldonado-Bernal
submission deadline 31 Oct 2026 | Viewed by 78 | Submission Open
Keywords: acute lymphoblastic leukemia; minimal residual disease; molecular drivers; genetic drivers treatment approaches; immunotherapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Insights on the Efficacy and Safety of Cytotoxic Agents in Lung Cancer submission deadline 31 Oct 2026 | Viewed by 78 | Submission Open
Keywords: lung cancer; cytotoxic agents; chemotherapy; antibody– drug conjugates; non-small-cell lung cancer; small-cell lung cancer; drug safety; platinum-based chemotherapy; drug resistance
(This special issue belongs to the Section Molecular Oncology)
T-Cell Function and Molecular Regulation
edited by and
submission deadline 31 Oct 2026 | Viewed by 78 | Submission Open
Keywords: T-cell activation and differentiation; immune checkpoints; signaling pathways; epigenetic modifications; immune tolerance; T-cell exhaustion; adoptive immunotherapy; cytokine signaling
(This special issue belongs to the Section Molecular Immunology)
Novel Molecular Targets and Prognostic Markers Focused on Improving Quality in Healthcare, 2nd Edition
edited by
submission deadline 31 Oct 2026 | Viewed by 78 | Submission Open
Keywords: prognostic markers; molecular targets; diagnostic tools
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Extracellular Vesicles: From Molecular Mechanisms to Therapeutic Applications: 2nd Edition
edited by Jung-Hyun Lee
submission deadline 31 Oct 2026 | Viewed by 78 | Submission Open
Keywords: extracellular vesicles; intercellular communications; biomarkers; drug delivery systems
(This special issue belongs to the Section Biochemistry)
Autophagy in Aging: Molecular Mechanisms and Therapeutic Implications
edited by
submission deadline 31 Oct 2026 | Viewed by 78 | Submission Open
Keywords: autophagy; aging; mitophagy; molecular mechanisms
(This special issue belongs to the Section Molecular Biology)
Plant–Fungal Disease Interactions: Pathogenesis, Epidemiology, and Management submission deadline 31 Oct 2026 | Viewed by 77 | Submission Open
Keywords: plant– fungal interactions; fungal pathogenesis; disease epidemiology; virulence mechanisms; soilborne pathogens; postharvest diseases; biological control; sustainable disease management; oomycetes; population genetics
(This special issue belongs to the Section Molecular Plant Sciences)
Functional Emulsion Systems in Pharmaceutical Science: Stability, Drug Delivery, and Biocatalytic Applications
edited by
submission deadline 31 Oct 2026 | Viewed by 76 | Submission Open
Keywords: emulsion systems; emulsion stability; drug delivery; pharmaceutical formulations; surfactants; supports; enzyme immobilization; biocatalysis; chiral drugs; kinetic resolution; enantioselective synthesis; lipolytic activity
(This special issue belongs to the Section Molecular Pharmacology)
Pharmacological Perspectives for Natural Products
edited by Ilsamar Mendes Soares
submission deadline 31 Oct 2026 | Viewed by 76 | Submission Open
Keywords: natural products; pharmacology; bioactivity; molecular targets; ethnopharmacology
(This special issue belongs to the Section Molecular Pharmacology)
Protein S in Coagulation, Inflammation, and Cancer
edited by
submission deadline 31 Oct 2026 | Viewed by 75 | Submission Open
Keywords: Protein S; hemostasis; anticoagulation; inflammation; cancer biology; thrombotic disorders; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Oncology)
Molecular Biomarkers and Mechanisms of Environmental Exposure submission deadline 31 Oct 2026 | Viewed by 73 | Submission Open
Keywords: multi-omics technologies; molecular toxicology; environmental toxicants; toxicants; mechanism of toxicity; biomarkers; in vitro; in vivo; human model; health
(This special issue belongs to the Section Molecular Toxicology)
Nano–Plant Interactions: Molecular Mechanisms and Applications in In Vitro Systems
edited by
submission deadline 31 Oct 2026 | Viewed by 73 | Submission Open
Keywords: nano– plant interactions; nanomaterials; nanoparticle uptake; plant tissue cultures; nanoparticle-induced molecular responses
(This special issue belongs to the Section Molecular Plant Sciences)
The Multiple Roles of RNA and RNases
edited by
submission deadline 31 Oct 2026 | Viewed by 73 | Submission Open
Keywords: RNA; RNase; diagnosis markers; drug design; cell signalling; immunology; infection; cancer; structural biology; RNA-binding proteins; RNA recognition patterns; RNA catalysis
(This special issue belongs to the Section Molecular Biology)
Respiratory Tract Infections: Molecular Pathogenesis, Advanced Diagnostics, and Translational Strategies
edited by Roy Rillera Marzo
submission deadline 31 Oct 2026 | Viewed by 73 | Submission Open
Keywords: respiratory tract infections; host– pathogen interactions; molecular diagnostics; genomics and proteomics; antimicrobial resistance; biomarkers; immune response; precision medicine; translational research; infectious disease epidemiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Integrative Genetic and Multi-Omics Approaches to Disease Biology
edited by
submission deadline 31 Oct 2026 | Viewed by 72 | Submission Open
Keywords: disease genes; human genomics; GWAS; multi-omics; regulatory genomics; mendelian randomisation; gene prioritisation; pleiotropy; precision medicine; translational genetics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Studies on Natural Products: Anti-Inflammatory, Immune Response, and Anti-Bacterial Activities
edited by Hicham Wahnou
submission deadline 31 Oct 2026 | Viewed by 72 | Submission Open
Keywords: natural products; anti-inflammatory; immune response; antibacterial; molecular mechanisms; phytochemicals; immunomodulation; probiotics; prebiotics; synbiotics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Multi-Omics and AI-Driven Discovery of Abiotic Stress Resilience in Crops
edited by
submission deadline 31 Oct 2026 | Viewed by 71 | Submission Open
Keywords: genomics; pangenome; abiotic stress; multi-omics; artificial intelligence; climate extremes; predictive breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Beyond the Single Gene: The Polygenic Architecture of Drug Response submission deadline 31 Oct 2026 | Viewed by 71 | Submission Open
Keywords: pharmacogenomics; pharmacogenetics; polygenic architecture; polygenic risk scores; precision medicine; adverse drug reactions; epistasis/gene– gene interactions; genomic biomarkers
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Biology of Histone Demethylases
edited by
submission deadline 31 Oct 2026 | Viewed by 71 | Submission Open
Keywords: histone demethylase and transcriptional regulation; histone demethylase function; histone demethylase and cancer; histone methylation and genotoxic damage; histone demethylase expression
(This special issue belongs to the Section Molecular Biology)
Discovery, Synthesis, and Therapeutic Applications of Enzyme Inhibitors submission deadline 31 Oct 2026 | Viewed by 69 | Submission Open
Keywords: cardiovascular diseases; neuroinflammation; neurodegeneration; cancer; clinical trial
(This special issue belongs to the Section Biochemistry)
Natural Products and Functional Biomaterials in Wound Healing and Cancer Treatment
edited by Shaik Nyamathulla
submission deadline 31 Oct 2026 | Viewed by 68 | Submission Open
Keywords: cancer; wound healing; biomaterials; diabetes; cytokines
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Inherited Metabolic Disorders: Genetic Insights and Therapeutic Strategies
edited by and Kristiane Michelin-Tirelli
submission deadline 31 Oct 2026 | Viewed by 68 | Submission Open
Keywords: inherited metabolic disorders; animal models; biomarkers; clinical laboratory techniques; tandem mass spectrometry; high-throughput nucleotide sequencing; cell- and tissue-based therapy; genetic therapy; enzyme replacement therapy; precision medicine
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advanced Drug Delivery Systems: From Nanocarrier Design to Translation Application
edited by Santu Sarkar
submission deadline 31 Oct 2026 | Viewed by 68 | Submission Open
Keywords: nanocarriers; clinical translation; targeted delivery; immunogenicity; formulation strategies
(This special issue belongs to the Section Molecular Nanoscience)
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