Biological Polyphenols in Cognitive Impairment-Related Diseases: Effects, Dosage and Molecular Mechanisms
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 9
Special Issue Editor
Interests: plant polyphenols chemistry; structure–activity relationship; molecular mechanisms; high value utilization
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cognitive impairment-related diseases (CIRD), including Cognitive impairment, Alzheimer's disease (AD), Parkinson's disease (PD), and other forms of neurodegenerative disorders, represent a growing global health challenge with profound social and economic consequences.
Recently, natural polyphenols have emerged as promising candidates for preventing and mitigating cognitive decline. These compounds act on multiple pathological mechanisms simultaneously, offering a multi-targeted therapeutic approach that fundamentally differs from conventional single-target therapies. However, polyphenols are ubiquitously found in various materials with great difference in structure, leading to great difference in CIRD prevention and treatment effects, as well as effective dosage and molecular mechanisms. In addition, the mechanisms underlying these effects remain unclear. Therefore, further experimental investigations—both in vitro and in vivo—are needed to elucidate the mechanisms of action of natural polyphenols in relation to CIRDs. Such analyses should be grounded in molecular-level research to advance the development of 21st-century molecular medicine.
Prof. Dr. Chunmei Li
Guest Editor
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Keywords
- natural polyphenols
- cognitive impairment-related diseases
- Alzheimer's disease
- Parkinson's disease
- depression
- anxiety
- lowest effective dose
- molecular mechanisms
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