Molecular Insights into Cardiomyopathy

Dear Colleagues,

Cardiomyopathies comprise a heterogeneous group of heart muscle disorders with diverse etiologies, including genetic, metabolic, inflammatory, and hormonal reasons. For many years, therapeutic strategies were largely limited to heart failure therapy, as no targeted therapies were yet available. However, recent advances in molecular research have transformed this paradigm. Studies elucidating the molecular and cellular pathways driving cardiomyopathy have provided the foundation for mechanism-based therapies. Notable examples are the advent of transthyretin stabilizers such as tafamidis in cardiac amyloidosis and myosin modulators like mavacamten in hypertrophic cardiomyopathy. These therapeutic breakthroughs demonstrate how insights into molecular pathophysiology can directly translate into disease-specific treatments that improve morbidity, mortality, and quality of life for affected patients.

This Special Issue of the International Journal of Molecular Sciences is dedicated to advancing our understanding of the molecular mechanisms underlying cardiomyopathies. It brings together original research articles and comprehensive reviews addressing genetic, biochemical, and cellular aspects of disease development and progression, as well as translational studies exploring novel therapeutic targets. By highlighting the intersection of basic molecular science and clinical application, this collection aims to provide a platform for innovative concepts that may pave the way for new disease-modifying therapies.

Dr. Selina Hein
Guest Editor

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