Molecular Insights into Pediatric Cancer: Advances in Hematopoietic Stem Cell Research
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 November 2026 | Viewed by 356
Editor
Special Issue Information
Dear Colleagues,
Hematopoietic stem cells are a rare population of precursor cells with the capacity to achieve multilineage differentiation while maintaining the potential to self-renew. They are key in normal hematopoiesis and in the genesis of diseases arising in the bone marrow, since they warrant blood cell homeostasis. Understanding the biology and mechanisms that regulate normal hematopoiesis and the crosstalk between bone marrow progenitors and the microenvironment allows for a better understanding of the therapeutic potential of targeting both hematopoietic stem cells and the microenvironment in these diseases.
This Special Issue aims to showcase recent advances in our understanding of the role of the bone marrow microenvironment in normal and pathological conditions in which the derangement of hematopoiesis causes overt diseases. In pediatric age groups, myelo- and lymphoproliferative diseases mainly arise from clonal immature precursors derived from hematopoietic precursors. Hematopoietic stem cells also represent a source of treatment in different clinical conditions. Both malignant and non-malignant hematological diseases may benefit from an improved and deeper understanding of the biology of hematopoietic stem cells.
Dr. Paola Muggeo
Guest Editor
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Keywords
- bone marrow
- microenvironment
- precursor
- hematopoietic stem cells
- pediatric hematological malignancies
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