Mitochondrial Functions and Dynamics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 690
Special Issue Editor
Special Issue Information
Dear Colleagues,
It has become increasingly evident that mitochondria play a role far beyond their traditional designation as the powerhouses of the cell. Indeed, mitochondria serve as the second most important calcium reservoir in cells, capable of exchanging calcium with the endoplasmic reticulum. Mitochondria are involved in oxidative stress, redox regulation, apoptosis, and aging. They integrate intracellular signals, contributing to the coordination of cellular functions. Recent studies have highlighted that mitochondria can be exchanged between different cell types and can even be found circulating in the bloodstream. Their role in immunomodulation, particularly concerning complex II (CII) activity, has emerged. Portions of mitochondria, or even mitochondrial DNA (mtDNA), can be released by one cell and taken up by neighboring cells. Moreover, the relationship between mitochondrial cristal shape and bioenergetic function presents another intriguing challenge for scientists. Exploring these various topics could lead to breakthroughs in addressing a range of pathological conditions associated with mitochondrial dysfunction.
We invite authors to submit articles on recent findings regarding the biochemical and molecular mechanisms of mitochondrial functions. Topics include mitochondrial biogenesis, bioenergetics, apoptosis, mitophagy, reactive oxygen species, calcium homeostasis, interactions with other organelles, and the link between mitochondrial dysfunction and cellular pathophysiology. Computational studies are also welcome.
Dr. Raffaella Isola
Guest Editor
Manuscript Submission Information
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Keywords
- bioenergetics
- mitochondrial biogenesis
- mitochondrial morphology
- apoptosis
- mitophagy
- reactive oxygen species
- calcium homeostasis
- cardiovascular diseases
- neurodegenerative diseases
- in vitro, cellular, and animal models
- myopathies
- mitochondria and immune system
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