Regulation of Gene Expression in Cell Differentiation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 30
Special Issue Editor
2. Center on Advanced Studies and Technologies (CAST), “G. d’Annunzio” University of Chieti-Pescara, 66100 Chieti, Italy
Interests: cellular biology; molecular biology; citology; histology; TEM (tranmission electron microscopy); cell differentiation; autophagy
Special Issue Information
Dear Colleagues,
Gene expression regulation is a fundamental process in cell differentiation influencing embryonic and tissue development, homeostasis and regeneration.
Recent discoveries reveal its critical role in longevity, aging, regenerative medicine and disease.
Many external signals, including small molecules, secreted proteins, temperature, oxygen, extracellular matrix, cell interaction and bioactive components of food, coordinate and regulate changes in gene expression during differentiation. Autophagy plays a crucial role in this process, maintaining cellular homeostasis, recycling damaged components and influencing transcriptional networks to control stem cell fate. Mechanobiology highlights how mechanical forces are transduced into biochemical signals that regulate transcriptional programs.
This Special Issue aims to report recent advances in the regulation and modulation of cellular differentiation to improve longevity and combat degenerative conditions and diseases; to identify strategies for therapeutic interventions and applications in gene therapy; defective gene regulation in cancer progression; nutrition as a prevention of obesity-related diseases; new applications in developmental biology, regenerative medicine, and cell therapies.
Dr. Iole Robuffo
Guest Editor
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Keywords
- cell differentiation
- gene expression regulation
- signal transduction
- autophagy
- nutrigenomics
- mechanobiology
- longevity
- aging mechanism
- tumor progression
- regenerative medicine
- gene therapy
- tissue remodeling
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