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Viruses as Therapeutic Tools: Medical and Biotechnological Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 110

Special Issue Editor


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Guest Editor
Instituto de Biotecnología y Biología Molecular (IBBM, UNLP-CONICET), Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata B1900, Argentina
Interests: human virology; insect virology; host-pathogen interactions; arenavirus hemorrhagic fevers; infectious diseases; viral infections; emerging infectious diseases

Special Issue Information

Dear Colleagues,

Despite viral infections being responsible for many diseases, viruses have increasingly become powerful allies in basic and applied research. Understanding virus–host interactions and how the immune system prevents and eliminates viral infections is essential for developing therapeutic approaches and vaccines to protect against these diseases. Furthermore, viruses have become powerful biotechnological tools for recombinant protein expression, gene delivery, and non-infectious disease treatment, such as cancer.

This Special Issue is being overseen by Prof. Dr. Víctor Romanowski, with invaluable assistance provided by Dr. Matias Luis Pidre from the Universidad Nacional de La Plata. The main objective of this Special Issue is to improve the current state of the literature by including works that explore key issues in applied virology, covering topics such as vaccine candidate development, antiviral strategies, and the use of viruses as gene therapy vectors, among others. We will also be open to receiving articles about virus–host interactions, from human viruses to animal viruses that lead to the generation of new technological tools or medical applications. We encourage you to contribute to this Special Issue: both original research and review articles are welcome.

Prof. Dr. Víctor Romanowski
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • molecular virology
  • virus–host interactions
  • immunology
  • gene therapy vectors
  • vaccines
  • antivirals

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Published Papers (1 paper)

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Review

27 pages, 852 KiB  
Review
Neutralizing Antibodies: Role in Immune Response and Viral Vector Based Gene Therapy
by Tatiana S. Tsaregorodtseva, Aigul A. Gubaidullina, Beata R. Kayumova, Alisa A. Shaimardanova, Shaza S. Issa, Valeriya V. Solovyeva, Albert A. Sufianov, Galina Z. Sufianova and Albert A. Rizvanov
Int. J. Mol. Sci. 2025, 26(11), 5224; https://doi.org/10.3390/ijms26115224 - 29 May 2025
Abstract
Neutralizing antibodies (nAbs) are an important component of the immune system, which plays a dual role in modern medicine. On the one hand, they significantly limit the effectiveness of gene therapy based on viral vectors, reducing the effectiveness of treatment of diseases such [...] Read more.
Neutralizing antibodies (nAbs) are an important component of the immune system, which plays a dual role in modern medicine. On the one hand, they significantly limit the effectiveness of gene therapy based on viral vectors, reducing the effectiveness of treatment of diseases such as spinal muscular atrophy, which is especially evident with repeated administration of therapeutic vectors. On the other hand, nAbs is a promising tool for combating viral infections. This review systematizes current data on the mechanisms of nAbs formation against AAV vectors, analyzes the factors influencing their production, and discusses strategies to overcome this limitation, including modification of vectors and the development of methods to suppress the immune response. Special attention is paid to the prospects of using nAbs as therapeutic agents against viral infections. The key problems and possible directions of research development in this area are considered, which is important for improving approaches to the treatment of both rare genetic and infectious diseases. Full article
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