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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms, Pathophysiology and Therapeutic Strategies of Chronic Obstructive Pulmonary Disease (COPD)

edited by

Shih-feng Liu

submission deadline 20 Jul 2025 | 2 articles | Viewed by 2088 | Submission Open

Keywords: chronic obstructive pulmonary disease (COPD); pathophysiology; novel therapeutic approaches; biomarkers; pulmonary rehabilitation; inflammation; oxidative stress; genetic factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research on Advanced Bioanalytical Approaches for Biomolecules Detection

edited by

Almira Ramanaviciene

Anton Popov

and

Asta Kausaite-Minkstimiene

submission deadline 20 Jul 2025 | 1 articles | Viewed by 2068 | Submission Open

Keywords: biosensors; immunosensors; immuno- or bio-assay; molecularly imprinted polymers; nanoparticles; biomarkers; analytical signal amplification strategies

(This special issue belongs to the Section Molecular Informatics)

From Kidney Disease to Hypertension: Molecular Basis and Pathophysiology

edited by

Alexis A. Gonzalez

submission deadline 20 Jul 2025 | 2 articles | Viewed by 2052 | Submission Open

Keywords: renin-angiotensin-aldosterone system; endothelial cell dysfunction; systemic inflammation; hypertension; oxidative stress; vascular remodeling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Genetic Studies on Tourette Syndrome and Comorbid Disorders

edited by Jakub P. Fichna and Natalia Szejko

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1994 | Submission Open

Keywords: Tourette syndrome; genetics and genomics; molecular neurobiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Insights into Mitochondrial Iron Metabolism: Connections to Cancer and Other Pathologies

edited by Michael Petronek

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1983 | Submission Open

Keywords: iron metabolism; mitochondrial iron; cellular homeostasis; iron– sulfur cluster biogenesis; heme synthesis; mitochondrial ferritin; cancer biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biology and Targeted Therapies in Leukemias

edited by Fabio Stagno and

Stefania Stella

submission deadline 20 Jul 2025 | 2 articles | Viewed by 1945 | Submission Open

Keywords: molecular biology; target therapy; leukemia; TKI; BCL-2; FLT3; CAR-T cells; CML

(This special issue belongs to the Section Molecular Oncology)

The Role of Neurons in Human Health and Disease—3rd Edition

edited by

Yasemin M. Akay

submission deadline 20 Jul 2025 | 2 articles | Viewed by 1940 | Submission Open

Keywords: brain; nervous system; neurons; immune system; human health and disease

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Human Papillomavirus (HPV) Research

edited by

Jane Shen-Gunther

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1933 | Submission Open

Keywords: human papillomavirus (HPV)/genetics; HPV-associated cancers; HPV cell-free DNA (cfDNA); HPV circulating tumor DNA (ctDNA); HPV circulating tumor cells (CTCs); carcinogenesis/genetics; CRISPR-cas systems/genetics; digital PCR; molecular diagnostics/methods; point-of-care diagnostics/methods; next-generation sequencing/methods; single-cell sequencing/methods; genomics; epigenomics; proteomics; metagenomics; phylogenomics; virus evolution; virus– host interactions; virus integration/genetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research on Gene Mutations in Cancer and Chronic Diseases

edited by Adam Szpechciński

submission deadline 20 Jul 2025 | 2 articles | Viewed by 1919 | Submission Open

Keywords: germline and somatic mutation; pathogenesis of cancer and chronic diseases; molecular techniques for gene mutation detection; biomarkers; molecular diagnostics; bioinformatics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Inflammation in Atherosclerosis: Current Advances

edited by Tuva B. Dahl

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1917 | Submission Open

Keywords: inflammation; atherosclerosis; cardiovascular disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nucleic Acid Recognition and Pharmaceutical Ligand Design

edited by

Marijana Radić Stojković

and

Atanas Kurutos

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1916 | Submission Open

Keywords: nucleic acid recognition; ligand design; analytical techniques; computational chemistry; therapeutics

(This special issue belongs to the Section Macromolecules)

Molecular Mechanisms of Bioactive Compounds Against Cancer—From Natural Sources to Drug Candidates

edited by

Agnieszka Pyrczak-Felczykowska

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1915 | Submission Open

Keywords: cancer; bioactive compounds; anticancer drugs; cancer treatment; natural products

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Mechanisms of Heart Failure: Insights and Therapeutic Strategies

edited by Emilio Vanoli and Eugenio Caradonna

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1882 | Submission Open

Keywords: heart failure; autonomic nervous system; brain– gut interaction; gut microbiota; neurohumoral treatment; cardiac remodeling; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Nanomedicine Innovation in Cancer Treatment

edited by Tijani Gharbi

submission deadline 20 Jul 2025 | 2 articles | Viewed by 1873 | Submission Open

Keywords: nanotechnology; nanomedicine; radiotherapy; theragnostic; antibody– drug conjugates (ADCs); drug delivery; radiopharmaceutical; gold nanoparticles; nanoparticle– biomolecule conjugate

(This special issue belongs to the Section Molecular Nanoscience)

Erythrocyte Cell Death: Molecular Insights

edited by

Anton Tkachenko

submission deadline 20 Jul 2025 | 2 articles | Viewed by 1852 | Submission Open

Keywords: cell death signaling; eryptosis; erythrocyte senescence; erythrocytes; necroptosis; regulated cell death

(This special issue belongs to the Section Molecular Biology)

Coumarins as Effective Therapeutic Agents: Mechanism of Action and Diverse Activity

edited by

Jarosław Widelski

submission deadline 20 Jul 2025 | 2 articles | Viewed by 1821 | Submission Open

Keywords: furanocoumarins; pyranocoumarins; simple coumarins; anti-inflammatory properties; cytotoxic activity; antitumor activity; antimicrobial acitivity; bioactivity of compounds; anxiolytic activity; neuroprotective properties; bioactive metabolites; medicinal plants

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biology of Liver Diseases: Pathogenesis, Diagnostics and Treatment

edited by

Rosaria Maria Pipitone

and Stefania Grimaudo

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1813 | Submission Open

Keywords: non-alcoholic fatty liver disease; steatosis; fibrogenesis; hepatocellular carcinoma; hepatocytes; hepatic stellate cells; inflammation; oxidative stress; efferocytosis; apoptosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Advances in Gut Microbiota in Human Diseases and Health

edited by

Avinash Karpe

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1756 | Submission Open

Keywords: antimicrobial and multidrug resistance (AMR; MDR); gut microbiome; systems biology; novel technologies; principles and mechanism of action; food and nutrition; food as Medicine

(This special issue belongs to the Section Molecular Microbiology)

Recent Advancements in Natural and Synthetic DNA/RNA G-Quadruplex Binders

edited by Magdalena Frańska

submission deadline 20 Jul 2025 | 2 articles | Viewed by 1753 | Submission Open

Keywords: guanine; guanosine; G-tetrad; G-quadruplex-interactive agent; binding agent; nucleic acids

(This special issue belongs to the Section Biochemistry)

New Advances in the Treatment and Diagnosis of Neuromuscular Diseases

edited by Silvia Consalvi

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1752 | Submission Open

Keywords: neuromuscular diseases; gene therapies; stem cell therapy; treatment and diagnosis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research of Cancer Metabolism and Biomarkers

edited by

Mario Cioce

submission deadline 20 Jul 2025 | 2 articles | Viewed by 1739 | Submission Open

Keywords: metabolic reprogramming; tumor microenvironment (TME); resistance; metabolic modulator; multidisciplinary omics approach; cancer metabolism; biomarkers; cancer stem cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Stem Cells in Health and Disease: 3rd Edition

edited by

Maja Ludvigsen

submission deadline 20 Jul 2025 | 2 articles | Viewed by 1689 | Submission Open

Keywords: stem cell regulation; differentiation; pluripotency; reprogramming; stem cell therapy; cancer stem cell/tumor-initiating cell; therapy resistance; regenerative medicine; metabolic plasticity

(This special issue belongs to the Section Molecular Biology)

Oxidative Stress in Dermatology, Aesthetics and Regenerative Medicine

edited by

Eugenio Luigi Iorio

submission deadline 20 Jul 2025 | Viewed by 1684 | Submission Open

Keywords: oxidative stress; redox system; antioxidant chemical species; dermatology; aesthetics; regenerative medicine; inflammatory; degenerative skin diseases

(This special issue belongs to the Section Molecular Biology)

Inflammatory Bowel Disease and Microbiome

edited by Abigail Raffner Basson

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1659 | Submission Open

Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; gut microbiota; diet; treatment; pathogenesis; biomarker

(This special issue belongs to the Section Molecular Microbiology)

Proteomics: An Invaluable Tool to Gain Information on Biological Systems and Their Disease Alterations

edited by

Paolo Iadarola

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1639 | Submission Open

Keywords: high-performance liquid chromatography; two-dimensional electrophoresis; mass spectrometry; biomarker discovery; bioinformatic analysis; biological systems; human fluids; post-translational modifications; protein– protein interaction

(This special issue belongs to the Section Molecular Informatics)

Molecular Biology of Lung Cancer: From Intrinsic to Acquired Resistance Mechanisms

edited by

Federico Pio Fabrizio

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1592 | Submission Open

Keywords: lung cancer; NSCLC; cancer therapy; resistance; DNA methylation

(This special issue belongs to the Section Molecular Oncology)

Advances in Understanding Molecular Mechanisms Involved in Chronic Kidney Injury and Repair

edited by

Milica Bozic

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1559 | Submission Open

Keywords: kidney disease; ischemic kidney injury; renal fibrosis; obesity; inflammation; oxidative stress; autophagy; senescence; cell death; small ncRNA

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Omics Technologies in Molecular Biology

edited by

Andrés J. Cortés

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1540 | Submission Open

Keywords: omics technologies; genomics; transcriptomics; proteomics; metabolomics; lipidomics; phenomics; enviromics; big data; machine learning; molecular biology

(This special issue belongs to the Section Molecular Biology)

Advanced Oxidation Processes for the Decontamination of Emerging Contaminants and Disinfection of Pathogenic Microorganisms

edited by

Chengdu Qi

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1511 | Submission Open

Keywords: advanced oxidation processes; emerging contaminants; pathogenic microorganisms; disinfection; hydroxyl radical; sulfate radical; organic radical

(This special issue belongs to the Section Molecular Microbiology)

Exploring New Field in Hydrocolloids Research and Applications

edited by

Mihaela Violeta Ghica

, Cristina Elena Dinu-Pirvu and

Lacramioara Popa

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1493 | Submission Open

Keywords: drug delivery systems; controlled-release; targeted delivery; wound healing; tissue engineering; bioadhesive agents; transdermal patches; mucoadhesive hydrogels; ophthalmic preparations; oral disintegrating films; gastroretentive systems; rheology modifiers; textural characteristics; stabilizing agents; encapsulation for protection and stability (drugs; probiotics and bioactive compounds); 3D bioprinting; nutraceutical delivery

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

How Aging Results in Cognitive Decline: Molecular Mechanisms

edited by Holly Christian Hunsberger

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1487 | Submission Open

Keywords: aging; memory; hippocampus; neurodegeneration; sex; gender; exercise; synapses; metabolism; mitochondria

(This special issue belongs to the Section Molecular Neurobiology)

Pathogenesis and Molecular Treatment of Primary Liver Cancer

edited by

Diego F. Calvisi

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1471 | Submission Open

Keywords: primary liver cancer; cholangiocarcinoma; hepatocellular carcinoma; hepatoblastoma; molecular pathogenesis; targeted therapies; anticancer drug

(This special issue belongs to the Section Molecular Oncology)

G Protein-Coupled Receptor Drug Discovery: Recent Advances and Future Perspectives

edited by Boshi Huang and

Dongwei Kang

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1459 | Submission Open

Keywords: GPCR drug discovery; GPCR therapeutics; drug design and synthesis; structural biology; preclinical evaluation

(This special issue belongs to the Section Molecular Pharmacology)

Hemophilia: From Pathophysiology to Novel Therapies

edited by

Mingching Shen

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1443 | Submission Open

Keywords: hemophilia; novel therapy in hemophilia; ultra-long half life clotting factor; clotting factor mimics; coagulation rebalancing agent; gene therapy; pathogenesis of hemophilia; molecular biology of hemophilia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Molecular Insights and Therapeutic Strategies for Ocular Vascular Pathologies

edited by Raquel Lima e Silva

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1427 | Submission Open

Keywords: VEGF pathway; anti-VEGF therapy; retinal neovascularization; choroidal neovascularization; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms: New Insights into the Pathogenesis of Neonatal Disorders

edited by

Rozeta Sokou

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1355 | Submission Open

Keywords: neonate; neonatal infections; molecular and cellular mechanisms; necrotizing enterocolitis; immature immune system; neonatal inflammation; epigenetic modification; regulatory RNAs; bronchopulmonary dysplasia; neonatal hypoxic– ischemic injury

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Discovery, Extraction, Synthesis, and Application of Natural Products

edited by

Hah Young Yoo

, Kang Hyun Lee and

Taek Lee

submission deadline 20 Jul 2025 | 2 articles | Viewed by 1350 | Submission Open

Keywords: antibiotics; antioxidants; biomass; bioactive molecule; biological activity; biosynthesis; biosensor; biomedicine; biotechnology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mast Cells in Human Health and Diseases—3rd Edition

edited by

Giovanna Traina

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1346 | Submission Open

Keywords: mast cells; human diseases; pain; cardiovascular diseases; microbiome; food allergy; stress; cancer

(This special issue belongs to the Section Molecular Biology)

The Role and Mechanisms of Natural Products in Inflammatory Responses and Inflammatory Diseases

edited by

Young-Su Yi

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1325 | Submission Open

Keywords: natural product; bioactive component; inflammation; inflammatory disease; anti-inflammatory; mechanism

(This special issue belongs to the Section Molecular Immunology)

Melatonin Treatment in Diseases: From Clinical Application Research to Targeted Drug

edited by

Rita Rezzani

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1320 | Submission Open

Keywords: health and pathology; oxidative stress and inflammation; endothelial dysfunction; aging and cancer; skin diseases; gastrointestinal disorders; neurodegenerative and cardiovascular diseases; microbiota composition and function; brain-gut axis; metabolic syndromes; sex/gender dimorphism

(This special issue belongs to the Section Molecular Biology)

Pigment Cells: From Biology to Medicine

edited by

Jakub Rok

submission deadline 20 Jul 2025 | 2 articles | Viewed by 1240 | Submission Open

Keywords: melanin; melanocyte; melanogenesis; melanoma; melanosome; neuromelanin; photoprotection; oxidative stress; phototoxicity; pigmentation disorders; drug– melanin complexes; skin cancer; UV radiation; retinal pigment epithelium

(This special issue belongs to the Section Molecular Biology)

Progress in the Use of Graphene and Graphene-Like Materials in Various Applications

edited by Piotr Kamedulski

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1220 | Submission Open

Keywords: graphene; porous carbons; carbon-based materials; 3D graphene; graphene exfoliation; nanotubes; nanomaterials; N-rich nano-porous carbon matrixes; N-rich activated carbons; carbon molecular sieves; hybrid materials; medical applications

(This special issue belongs to the Section Materials Science)

Prostate Cancer Research Update: Molecular Diagnostic Biomarkers

edited by Mikhail Baryshev

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1218 | Submission Open

Keywords: prostate cancer; molecular biomarkers; cancer-specific DNA methylation; non-coding genes; gene fusions; lncRNA

(This special issue belongs to the Section Molecular Oncology)

Micro(nano) Plastics and Estrogens as Endocrine Disruptors Meet the Female Reproductive System, Breast and Colon: What Is Going On?

edited by

Anna Maria Giuseppina Poma

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1163 | Submission Open

Keywords: micro(nano) plastics; estrogens; endocrine disruptors; female reproductive system; breast; colon

(This special issue belongs to the Section Molecular Biology)

Molecular Targets in Gastrointestinal Diseases

edited by

Changwon Yang

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1124 | Submission Open

Keywords: molecular pathways; gastrointestinal cancers; inflammatory bowel disease; targeted therapies; microbiota; gene editing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pathology and Treatment of Spinal Cord Injury

edited by James Hong

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1076 | Submission Open

Keywords: spinal cord injury; neuroinflammation; gene targets; neural regeneration; synaptic plasticity; molecular pathways; biomarkers; oxidative stress; apoptosis; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Signaling Pathways in Alzheimer’s Disease

edited by

Alberto Ouro

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1076 | Submission Open

Keywords: Alzheimer’ s disease; aging; β -amyloid; biomarkers; cell signaling; tau; mitochondrial dysfunction; neuroinflammation; vascular alterations

(This special issue belongs to the Section Molecular Neurobiology)

Lipid Droplet Proteins Function and Metabolism

edited by

Vitor Teixeira

submission deadline 20 Jul 2025 | 1 articles | Viewed by 1026 | Submission Open

Keywords: lipid droplets; LD protein; LD metabolism

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms and Therapies of Hematological Tumors

edited by

Maria Teresa Bochicchio

and