ijms-logo

Journal Browser

Journal Browser

Molecular Pathology and Treatment of Spinal Cord Injury

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 1686

Special Issue Editor


E-Mail Website
Guest Editor
University Health Network, Toronto, ON, Canada
Interests: spinal cord injury; machine learning

Special Issue Information

Dear Colleagues,

This Special Issue on "Molecular Pathology and Treatment of Spinal Cord Injury" aims to advance our understanding of the intricate molecular mechanisms underlying spinal cord injury (SCI) and explore innovative therapeutic strategies for promoting recovery. This Special Issue invites original research articles, comprehensive reviews, and cutting-edge perspectives that delve into the molecular and cellular pathways contributing to SCI pathology, including neuroinflammation, oxidative stress, apoptosis, and synaptic plasticity. Emphasis is placed on novel gene targets, and their roles in neural regeneration and functional recovery. We also seek studies employing advanced techniques, such as spatial and single-cell RNA sequencing, to uncover new biomarkers and therapeutic targets. Contributions focusing on translational research that bridges the gap between molecular insights and clinical applications are particularly welcome. By highlighting groundbreaking discoveries and fostering interdisciplinary collaboration, this Special Issue aims to pave the way for innovative treatments that can significantly improve the quality of life for individuals affected by SCI.

Dr. James Hong
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • spinal cord injury
  • neuroinflammation
  • gene targets
  • neural regeneration
  • synaptic plasticity
  • molecular pathways
  • biomarkers
  • oxidative stress
  • apoptosis
  • translational research

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

16 pages, 2809 KiB  
Review
Personalized Stem Cell-Based Regeneration in Spinal Cord Injury Care
by Sasi Kumar Jagadeesan, Ryan Vimukthie Sandarage, Sathya Mathiyalagan and Eve Chung Tsai
Int. J. Mol. Sci. 2025, 26(8), 3874; https://doi.org/10.3390/ijms26083874 - 19 Apr 2025
Viewed by 1316
Abstract
Spinal cord injury (SCI) remains a major clinical challenge, with limited therapeutic options for restoring lost neurological function. While efforts to mitigate secondary damage have improved early-phase management, achieving sustained neurorepair and functional recovery remains elusive. Advances in stem cell engineering and regenerative [...] Read more.
Spinal cord injury (SCI) remains a major clinical challenge, with limited therapeutic options for restoring lost neurological function. While efforts to mitigate secondary damage have improved early-phase management, achieving sustained neurorepair and functional recovery remains elusive. Advances in stem cell engineering and regenerative medicine have opened new avenues for targeted interventions, particularly through the transplantation of neural stem/progenitor cells (NSPCs), induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs). However, patient-specific factors such as cellular senescence, genetic and epigenetic variability, injury microenvironment, and comorbidities influence the efficacy of stem cell therapies by affecting graft survival and differentiation. Overcoming these challenges necessitates cutting-edge technologies, including single-cell transcriptomics, CRISPR-mediated hypoimmunogenic engineering, and biomaterial-based delivery platforms, which enable personalized and precision-driven SCI repair. Leveraging these advancements may help stem cell therapies overcome translational barriers and establish clinically viable regenerative solutions. This review explores the intersection of patient-specific variability, bioengineering innovations, and transcriptomic-guided precision medicine to define the next frontier in SCI therapy. Full article
(This article belongs to the Special Issue Molecular Pathology and Treatment of Spinal Cord Injury)
Show Figures

Figure 1

Back to TopTop