Erythrocyte Cell Death: Molecular Insights
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 July 2025 | Viewed by 1853
Special Issue Editor
Special Issue Information
Dear Colleagues,
A growing body of evidence suggests that erythrocytes can undergo regulated cell death (RCD) modalities similar to apoptosis and necroptosis of nucleated cells. To emphasize the differences between these RCDs in mature erythrocytes and nucleated cells, the terms eryptosis and erythronecroptosis were introduced. Recent advances in the field have significantly expanded our knowledge on the cell death machinery of mature erythrocytes. However, additional studies could provide novel insights into the molecular mechanisms governing cell death pathways in mature erythrocytes. Accumulating evidence indicates that accelerated eryptosis is observed in multiple diseases, which can result in anemia and thrombosis development. The possibility to target eryptosis pharmaceutically is still under investigation. The search for novel molecular pathways involved in initiation and execution of eryptosis and elucidation of the crosstalk between eryptosis and necroptosis in mature erythrocytes might reveal novel targets for therapeutic interventions in eryptosis-related diseases. The Special Issue will focus on the mechanisms regulating RCD modalities in mature erythrocytes, and the studies aiming to clarify them will be gladly welcomed.
Dr. Anton Tkachenko
Guest Editor
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Keywords
- cell death signaling
- eryptosis
- erythrocyte senescence
- erythrocytes
- necroptosis
- regulated cell death
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