Molecular Biology and Targeted Therapies in Leukemias

Dear Colleagues,

In recent decades, new advances in molecular biology have furthered our understanding of the mechanisms of several types of leukemias and enhanced our molecular and clinical knowledge. Investigations on several genetic driver mutations, oncogenes, tumor suppressor genes, epigenetic changes and signaling pathways have lead to the development of new drugs that specifically target the molecular and genetic abnormalities underlying distinct types of leukemia. Therefore, target therapy is revolutionizing classical leukemia treatments, aiming to improve clinical outcomes by selectively targeting leukemia cells and minimizing the damage to normal tissue cells. The introduction of tyrosine kinase inhibitors, FLT3 and BCL-2 inhibitors, epigenetic modulators and CAR-T cell therapies into the clinical therapeutic scenario has enhanced clinical progress. This Special Issue will focus on both the biomolecular mechanisms and the efficacy of novel target treatments in leukemias through showcasing original research articles and reviews.

Dr. Fabio Stagno
Dr. Stefania Stella
Guest Editors

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• molecular biology
• target therapy
• leukemia
• TKI
• BCL-2
• FLT3
• CAR-T cells
• CML