Molecular Biology of Liver Diseases: Pathogenesis, Diagnostics and Treatment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 July 2025 | Viewed by 1796
Special Issue Editors
Interests: study of molecular mechanisms involved in MAFLD development and progression in terms of MASH and HCC; evaluation of the effects of compounds and phytonutrient administration, potentially capable of improving the lipid and glucose metabolic profiles, as well as steatosis and hepatic fibrosis, on in vitro models of continuous human hepatoma cell lines (HepG2) and hepatic stellate cells (LX2)
Special Issues, Collections and Topics in MDPI journals
Interests: hepatitis; liver; hepatocellular carcinoma; liver diseases; liver cirrhosis; cirrhosis; liver diseases and immunology; liver failure; chronic hepatitis C; apoptosis
Special Issue Information
Dear Colleagues,
Non-alcoholic fatty liver disease (NAFLD), recently renamed metabolic-associated fatty liver disease (MAFLD), is the most prevalent form of chronic liver disease in the world. The pathogenic mechanism of NAFLD is heterogeneous, complex, and multifactorial, involving a combination of genetic and environmental factors, with an unhealthy lifestyle playing a crucial role in its development.
Studying the molecular mechanisms involved in NAFLD pathogenesis is crucial for developing effective prevention and treatment strategies. Indeed, although many drugs are under investigation, no pharmacological therapy has been approved for this condition, and it lacks adequate non-invasive biomarkers. To date, lifestyle changes play a dominant role in clinical practice.
Research on the pathogenetic mechanisms leading to NAFLD has made significant progress in recent years, though it remains unclear. Several molecular pathways have been proposed, and, to date, insulin resistance seems to be pivotal in the pathogenesis of both NAFLD and type 2 diabetes.
This Special Issue, entitled “Molecular Biology of Liver Diseases: Pathogenesis, Diagnostics and Treatment”, welcomes submissions of original research and review articles on the advancements in molecular mechanism discoveries and novel genetic risk factor identification to contribute to novel prevention and therapeutic approaches.
Dr. Rosaria Maria Pipitone
Dr. Stefania Grimaudo
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Keywords
- non-alcoholic fatty liver disease
- steatosis
- fibrogenesis
- hepatocellular carcinoma
- hepatocytes
- hepatic stellate cells
- inflammation
- oxidative stress
- efferocytosis
- apoptosis
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