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Recent Advances in Human Papillomavirus (HPV) Research

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Guest Editor
Department of Molecular Medicine, University of Texas Health Science Center at San Antonio (UT Health), San Antonio, TX 78229, USA
Interests: next-generation sequencing; oncoviruses; translational research; viral evolution; viral-host interaction

Special Issue Information

Dear Colleagues,

Human Papillomavirus (HPV)-associated diseases remain a significant global health challenge, contributing substantially to morbidity and mortality. These diseases impose severe health, social, and economic burdens. The World Health Organization (WHO) reports that HPV is the leading viral cause of cancer worldwide, accounting for ~570,000 new cervical cancer cases and 120,000 other anogenital and oropharyngeal cancer cases each year. Although controversial, HPV has also been associated with certain subsets of breast, esophageal, and colorectal cancers, highlighting the need for further basic research.

Recent advancements in molecular and “omics” technologies, laboratory instrumentation, and in silico analytical methods have significantly enhanced our understanding of HPV, mechanisms of carcinogenesis, viral–host interactions, viral evolution, and epidemiology. This Special Issue aims to create a platform for HPV researchers across various biomedical fields—including infectious diseases, virology, oncology, molecular biology, bioinformatics, and laboratory medicine—to exchange ideas, tools, and findings. The emphasis will be on the latest progress in employing novel molecular approaches or technologies in HPV or HPV-related research, spanning from basic science to population health.

We invite the submission of original research manuscripts, methods articles, and reviews that highlight the latest advancements across diverse thematic areas of HPV research.

Dr. Jane Shen-Gunther
Guest Editor

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Keywords

  • human papillomavirus (HPV)/genetics
  • HPV-associated cancers
  • HPV cell-free DNA (cfDNA)
  • HPV circulating tumor DNA (ctDNA)
  • HPV circulating tumor cells (CTCs)
  • carcinogenesis/genetics
  • CRISPR-cas systems/genetics
  • digital PCR
  • molecular diagnostics/methods
  • point-of-care diagnostics/methods
  • next-generation sequencing/methods
  • single-cell sequencing/methods
  • genomics
  • epigenomics
  • proteomics
  • metagenomics
  • phylogenomics
  • virus evolution
  • virus–host interactions
  • virus integration/genetics

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Published Papers (1 paper)

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Review

18 pages, 687 KiB  
Review
HPV Infection and Oral Microbiota: Interactions and Future Implications
by Qingqing Xia and Sarah Pierson
Int. J. Mol. Sci. 2025, 26(4), 1424; https://doi.org/10.3390/ijms26041424 - 8 Feb 2025
Viewed by 1479
Abstract
Human papillomavirus (HPV) is a leading cause of mucosal cancers, including the increasing incidence of HPV-related head and neck cancers. The oral microbiota—a diverse community of bacteria, fungi, and viruses—play a critical role in oral and systemic health. Oral microbiota dysbiosis is increasingly [...] Read more.
Human papillomavirus (HPV) is a leading cause of mucosal cancers, including the increasing incidence of HPV-related head and neck cancers. The oral microbiota—a diverse community of bacteria, fungi, and viruses—play a critical role in oral and systemic health. Oral microbiota dysbiosis is increasingly linked to inflammation, immune suppression, and cancer progression. Recent studies have highlighted a complex interaction between HPV and oral microbiota, suggesting this interplay influences viral persistence, immune response and the tumor microenvironment. These interactions hold significant implications for disease progression, clinical outcomes, and therapeutic approaches. Furthermore, the oral microbiota has emerged as a promising biomarker for HPV detection and disease progress assessment. In addition, probiotic-based treatments are gaining attention as an innovative approach for preventing or treating HPV-related cancers by modulating the microbial environment. In this review, current research on the interaction between HPV and oral microbiota is provided, their clinical implications are explored, and the future potential for utilizing microbiota for diagnostic and therapeutic innovations in HPV-associated cancers is discussed. Full article
(This article belongs to the Special Issue Recent Advances in Human Papillomavirus (HPV) Research)
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