How Aging Results in Cognitive Decline: Molecular Mechanisms
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 July 2025 | Viewed by 1488
Special Issue Editor
Interests: Alzheimer’s disease (AD); behavioral neuroscience; age-related cognitive decline
Special Issue Information
Dear Colleagues,
One of our major accomplishments as a modern society is the increase in our life expectancy. However, this might also be our downfall as increasing age is often associated with impaired quality of life. Age is the greatest risk factor for neurodegeneration and cognitive decline, and understanding age-related changes in cognition is crucial, given the growing elderly population. In fact, about 40% of individuals aged 65 or older suffer some form of memory loss. Although a variety of molecular, structural, and functional changes occur in the brain during aging, the cause of cognitive decline is still unclear. Additionally, it is important to discern age-related cognitive decline from dementias. The dysfunction of synapses and cell machinery is often seen prior to memory impairments, with new evidence suggesting that metabolism and lifestyle play a significant role in age-related brain-wide changes. Additionally, how hormones, sex, and gender influence the aging brain is of great interest. This Special Issue of IJMS invites original research and reviews, ranging from basic to translational science, focused on the latest developments concerning molecular mechanisms that regulate age-related cognitive decline.
Dr. Holly Christian Hunsberger
Guest Editor
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Keywords
- aging
- memory
- hippocampus
- neurodegeneration
- sex
- gender
- exercise
- synapses
- metabolism
- mitochondria
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