Pathogenesis and Molecular Treatment of Primary Liver Cancer
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 July 2025 | Viewed by 1471
Special Issue Editor
Special Issue Information
Dear Colleagues,
Primary liver cancer (PLC) is a group of tumor entities that are characterized by their high aggressiveness and dismal outcomes. PLC has steadily increased in incidence in recent decades and has become a significant health concern worldwide. Histologically, PLC mainly consists of hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (iCCA) in adulthood, and hepatoblastoma (HBL) in childhood. Due to its asymptomatic nature in the early phases of the disease, PLC is generally diagnosed when the tumor is inoperable, and systemic treatments have limited efficacy. Therefore, a better understanding of the molecular pathogenesis of PLC is imperative to improve patients’ outcomes. In recent years, numerous signaling cascades involved in PLC development and progression have been elucidated, and several molecularly and immunologically based therapies have been generated, with some becoming the first-line treatment for specific tumor subsets.
Given PLC’s importance in the medical and research fields, the International Journal of Molecular Sciences is launching this Special Issue.
Specifically, we aim to showcase the current knowledge on the molecular pathogenesis of PLC and the efforts on anticancer drug development. Original research articles, review articles, and short communications within the described research topic are welcome.
Dr. Diego F. Calvisi
Guest Editor
Manuscript Submission Information
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Keywords
- primary liver cancer
- cholangiocarcinoma
- hepatocellular carcinoma
- hepatoblastoma
- molecular pathogenesis
- targeted therapies
- anticancer drug
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