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Inflammatory Bowel Disease and Microbiome
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Inflammatory Bowel Disease and Microbiome

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 1525

Special Issue Editor

Dr. Abigail Raffner Basson

E-Mail Website1 Website2
Guest Editor
Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH, USA
Interests: inflammatory bowel disease; Crohn’s disease; nutrition; microbiome; diet in digestive diseases; overweight/obesity

Special Issue Information

Dear Colleagues,

This journal invites manuscripts that explore the latest advancements in the research of Inflammatory Bowel Disease (IBD), including Crohn’s disease and ulcerative colitis, with a particular focus on the gut microbiome and dietary factors. Submissions should present innovative findings on the etiology, pathophysiology, diagnosis, and treatment of IBD, emphasizing the role of diet and gut microbiota. We seek comprehensive reviews, original research articles, and clinical studies that provide new insights into how genetic, immunological, and environmental factors, particularly diet and microbiome interactions, contribute to IBD. Emphasis on novel therapeutic approaches, including dietary interventions and microbiome-based therapies, is highly encouraged. Manuscripts discussing advancements in diagnostic techniques, biomarker discovery, and the impact of gut microbiota on disease progression are particularly welcome. Additionally, studies addressing the effects of lifestyle and dietary habits on patient quality of life and disease management are of great interest. Our goal is to disseminate cutting-edge research that enhances understanding and improves clinical outcomes for individuals living with IBD through a focus on diet and the gut microbiome.

Dr. Abigail Raffner Basson
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammatory bowel disease
  • Crohn’s disease
  • ulcerative colitis
  • gut microbiota
  • diet
  • treatment
  • pathogenesis
  • biomarker

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Published Papers (1 paper)

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Review

28 pages, 1348 KiB  
Review
Gut Microbiota Serves as a Crucial Independent Biomarker in Inflammatory Bowel Disease (IBD)
by Bharti Sharma, George Agriantonis, Kate Twelker, Danielle Ebelle, Samantha Kiernan, Maham Siddiqui, Aditi Soni, Sittha Cheerasarn, Whenzdjyny Simon, Winston Jiang, Angie Cardona, Jessica Chapelet, Alexandra Z. Agathis, Alejandro Gamboa, Jasmine Dave, Juan Mestre, Navin D. Bhatia, Zahra Shaefee and Jennifer Whittington
Int. J. Mol. Sci. 2025, 26(6), 2503; https://doi.org/10.3390/ijms26062503 - 11 Mar 2025
Cited by 1 | Viewed by 1155
Abstract
Inflammatory bowel disease (IBD), encompassing Crohn’s disease (CD), ulcerative colitis (UC), and IBD unclassified (IBD-U), is a complex intestinal disorder influenced by genetic, environmental, and microbial factors. Recent evidence highlights the gut microbiota as a pivotal biomarker and modulator in IBD pathogenesis. Dysbiosis, [...] Read more.
Inflammatory bowel disease (IBD), encompassing Crohn’s disease (CD), ulcerative colitis (UC), and IBD unclassified (IBD-U), is a complex intestinal disorder influenced by genetic, environmental, and microbial factors. Recent evidence highlights the gut microbiota as a pivotal biomarker and modulator in IBD pathogenesis. Dysbiosis, characterized by reduced microbial diversity and altered composition, is a hallmark of IBD. A consistent decrease in anti-inflammatory bacteria, such as Faecalibacterium prausnitzii, and an increase in pro-inflammatory species, including Escherichia coli, have been observed. Metabolomic studies reveal decreased short-chain fatty acids (SCFAs) and secondary bile acids, critical for gut homeostasis, alongside elevated pro-inflammatory metabolites. The gut microbiota interacts with host immune pathways, influencing morphogens, glycosylation, and podoplanin (PDPN) expression. The disruption of glycosylation impairs mucosal barriers, while aberrant PDPN activity exacerbates inflammation. Additionally, microbial alterations contribute to oxidative stress, further destabilizing intestinal barriers. These molecular and cellular disruptions underscore the role of the microbiome in IBD pathophysiology. Emerging therapeutic strategies, including probiotics, prebiotics, and dietary interventions, aim to restore microbial balance and mitigate inflammation. Advanced studies on microbiota-targeted therapies reveal their potential to reduce disease severity and improve patient outcomes. Nevertheless, further research is needed to elucidate the bidirectional interactions between the gut microbiome and host immune responses and to translate these insights into clinical applications. This review consolidates current findings on the gut microbiota’s role in IBD, emphasizing its diagnostic and therapeutic implications, and advocates for the continued exploration of microbiome-based interventions to combat this debilitating disease. Full article
(This article belongs to the Special Issue Inflammatory Bowel Disease and Microbiome)
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