Molecular Mechanisms of Heart Failure: Insights and Therapeutic Strategies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 July 2025 | Viewed by 1634
Special Issue Editors
Interests: heart failure
Special Issue Information
Dear Colleagues,
Toward the end of the last century, the availability of ACE inhibitors and the novel understanding of the beta-blockers use, shifting from contraindicated to first-line therapy in heart failure, have completely shifted the medical goals of pharmacological therapy from disease symptom control to disease cure. This conceptual shift has finally highlighted the critical role of the autonomic nervous system in HF development and lethal progression. However, the neurohumoral treatment has, for the first time, affected HF prognosis by dramatically decreasing its related morbidity and mortality. The new millennium has brought focus on novel targets like BNP and neural stimulation. In more recent times, the long-lasting appreciation of HF as an inflammatory process has found novel lines of understanding, leading to new therapeutical approaches built on the molecular approaches. Among these, the brain–gut interaction is generating a growing bulk of evidence. Specifically, the evidence that gut microbiota products, e.g., TMAO, can not only affect brain function but also activate lethal inflammatory processes in the heart, thus favoring cardiac remodeling and determining its progression toward overt HF, deserves specific attention. Based on the above facts, this Special Issue is indeed dedicated to address this matter by distributing information generated from novel or resumed research about heart failure and its molecular pathologies and therapeutic strategies.
Dr. Emilio Vanoli
Dr. Eugenio Caradonna
Guest Editors
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Keywords
- heart failure
- autonomic nervous system
- brain–gut interaction
- gut microbiota
- neurohumoral treatment
- cardiac remodeling
- inflammation
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