Molecular Biology of Lung Cancer: From Intrinsic to Acquired Resistance Mechanisms
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: closed (20 February 2026) | Viewed by 3003
Special Issue Editor
Interests: epigenetics; molecular biology; lung cancer; DNA methylation; resistance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Overall, lung cancer remains one of the major causes of cancer-related deaths worldwide. Despite the big efforts in ameliorating therapeutic strategies, both intrinsic and acquired resistance represent a concrete obstacle to the effectiveness of long-term treatment, resulting in ineffective therapeutic action and poor prognosis of lung cancer patients. Resistance mechanisms currently include genetic mutations and/or epigenetic changes, unregulated overexpression of drug efflux pumps, reduced oxygen availability, genomic instability and other pathological molecular events. In this context, the deregulation of epigenetic mechanisms, as well as DNA methylation, histone modification, and non-coding RNA regulation, could contribute to tumor resistance. To this purpose, a comprehensive overview of the current knowledge about several mechanisms responsible for targeting genetic and/or epigenetic factors linked to therapeutic resistance could be an effective strategy to reverse or overcome acquired drug resistance in patients with solid cancer, particularly in lung cancer patients.
This special issue aims to focus on the understanding of current landscape of intrisinic and acquired resistance in lung cancer cells and patients after therapy and the potential interventions to overcome these resistance mechanisms.
We encourage contributions of original research articles and reviews in the field of both genetic and epigenetic mechanisms related to lung cancer research.
Dr. Federico Pio Fabrizio
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- lung cancer
- NSCLC
- cancer therapy
- resistance
- DNA methylation
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
