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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Environmental Heavy Metals with Their Benefits and Risks for Human Health
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 2664 | Submission Open
Keywords: heavy metals; metal compound; iron; copper; cadmium; arsenic; oxidative stress; cell death; toxicology; Wilson disease; hemochromatosis
(This special issue belongs to the Section Molecular Toxicology)
Molecular Mechanisms of Phytochemicals in Antioxidation, Antimicrobial, and Cytoprotective Properties
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2597 | Submission Open
Keywords: phytochemicals; antioxidant; antimicrobial; cytoprotective; in vitro screening; in vivo evaluation
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms and Functions of Extracellular Vesicles
edited by and Jameel M. Inal
submission deadline 20 Feb 2026 | 1 articles | Viewed by 2581 | Submission Open
Keywords: extracellular vesicles; molecular mechanisms; biomarkers; liquid biopsy; cell-communication; cellular function; pathobiology; clinical
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into the Role of Exercise in Disease and Health, 2nd Edition
edited by , María José Cuevas-González and Chun-Jung Huang
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2573 | Submission Open
Keywords: physical activity; molecular mechanisms; disease prevention; metabolic health; cardiovascular diseases; neurodegenerative diseases; sarcopenia; immune function; healthy aging; epigenetics
(This special issue belongs to the Section Molecular Biology)
Molecular Diagnosis and Treatment of Migraine
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 2541 | Submission Open
Keywords: migraine; pathophysiology; diagnostics; therapy; molecular mechanisms
(This special issue belongs to the Section Molecular Biology)
Exploring the Genetics in Rare Diseases: A Genomic Odyssey
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2535 | Submission Open
Keywords: novel discoveries in rare disorders; polygenic risk scores; mosaicism; protein interaction; tools utilized to engineer DNA; somatic variants; patient advocacy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Heart Failure: From Bench to Bedside
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2486 | Submission Open
Keywords: heart failure; cardiac biomarkers; medical therapy; molecular pathways; prognosis; target therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapeutic Targets in Cardiometabolic Disorders
edited by Massimiliano M. Corsi Romanelli and
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2478 | Submission Open
Keywords: atherosclerosis; angiotensin; endothelial cell; inflammation; biomarkers; gLP-1; sT-2
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advancing Liver Health: State of the Art and Recent Research Advances
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2458 | Submission Open
Keywords: liver; liver cancer and malignancy; liver transplantation; inflammation and immunity; liver health and ageing; molecular genomics; cellular senescence; metabolic dysfunction-associated liver disease; cirrhosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Impact of Biomolecules on the Pathogenesis of Oral and Periodontal Diseases
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2453 | Submission Open
Keywords: biomolecules; inflammatory mediators; enzymes; cytokines; dysbiosis; microbiome; genetic and epigenetic factors; oral and periodontal diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Protein Kinase in Disease, 2nd Edition submission deadline 20 Feb 2026 | 2 articles | Viewed by 2422 | Submission Open
Keywords: protein kinases; phosphorylation; cancers; inflammatory diseases; protein kinase inhibitors; anticancer drugs
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Biology of Lung Cancer: From Intrinsic to Acquired Resistance Mechanisms submission deadline 20 Feb 2026 | 1 articles | Viewed by 2417 | Submission Open
Keywords: lung cancer; NSCLC; cancer therapy; resistance; DNA methylation
(This special issue belongs to the Section Molecular Oncology)
Advances in Metabolic Phenotypes of Pediatric Obesity
edited by Simona Georgiana Popa
submission deadline 20 Feb 2026 | 1 articles | Viewed by 2407 | Submission Open
Keywords: cardiometabolic phenotypes of pediatric obesity; metabolomic profiles; microbiota; entero-insular axis; adipocytokines; precision therapy
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Toxicological Impacts of Emerging Contaminants on Aquatic Organisms
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 2327 | Submission Open
Keywords: aquatic toxicology; emerging contaminants; physiology and behavior; oxidative stress; antioxidant biomarkers; immunotoxicity; neuroendocrine toxicity; bioremediation; molecular mechanisms
(This special issue belongs to the Section Molecular Toxicology)
New Insights into the Antibacterial Effect of Nano- and Micro-Materials submission deadline 20 Feb 2026 | 1 articles | Viewed by 2278 | Submission Open
Keywords: antibacterial coatings; biomaterials; medical devices; antimicrobial resistance; nanomedicine
(This special issue belongs to the Section Materials Science)
Advances in Pathogenesis and Treatment of Skin Cancer (2nd Edition) submission deadline 20 Feb 2026 | 1 articles | Viewed by 2187 | Submission Open
Keywords: melanoma; squamous cell carcinoma; basal cell carcinoma; tumor microenvironment; epithelial– mesenchymal transition (EMT) process; ultraviolet radiation; oxidative stress; bioactive modulators; signal transduction pathways
(This special issue belongs to the Section Molecular Oncology)
Molecular Research on Dyslipidemia submission deadline 20 Feb 2026 | 2 articles | Viewed by 2119 | Submission Open
Keywords: dyslipidemia; chronic non-communicable diseases; dysregulation of lipid homeostasis; genetic and epigenetic regulation; lipidomics in personalized medicine; lipid biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research on Alloy Materials Microstructure and Their Functionalization
edited by and Celaletdin Ergun
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2100 | Submission Open
Keywords: alloy design; microstructure; production methods; additive manufacturing; sol– gel process; biofunctional materials; magnetic properties; nanoparticles; ceramics; composites
(This special issue belongs to the Section Materials Science)
Molecular Mechanisms and Therapeutic Strategies of Colorectal Cancer submission deadline 20 Feb 2026 | 2 articles | Viewed by 2051 | Submission Open
Keywords: colorectal cancer; tumor microenvironment; biomarkers; intercellular communication; therapeutic strategies
(This special issue belongs to the Section Molecular Oncology)
Plant Metabolism and Natural Product Biosynthesis
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 2010 | Submission Open
Keywords: plant metabolism; natural product; biosynthesis; metabolomics; bioinformatics
(This special issue belongs to the Section Molecular Plant Sciences)
Ruminant Physiology: Digestion, Metabolism, and Endocrine System
edited by Rui Hu
submission deadline 20 Feb 2026 | 1 articles | Viewed by 2006 | Submission Open
Keywords: ruminant physiology; digestive health; metabolic regulation; endocrine signaling; rumen microbiome; nutrient partitioning; methane mitigation; epigenetic modulation; nutritional stress adaptation
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Study on the Microenvironment in Lymphoma submission deadline 20 Feb 2026 | 2 articles | Viewed by 1980 | Submission Open
Keywords: tumor microenvironment; lymphoma; hodgkin lymphoma; non-hodgkin lymphoma; burkitt lymphoma; follicular lymphoma; waldenströ m’ s macroglobulinemia; NK/T-cell lymphoma; diffuse large B-cell lymphoma; mantle cell lymphoma; marginal zone lymphoma; lymphoproliferative disorder; anaplastic large cell lymphoma; mediastinal B cell lymphoma; T-cell lymphomas
(This special issue belongs to the Section Molecular Oncology)
Harnessing Bioinformatics for miRNA Research: Methods, Insights and Applications
edited by Maria Rosaria Tumolo and Saverio Sabina
submission deadline 20 Feb 2026 | 2 articles | Viewed by 1957 | Submission Open
Keywords: microRNA; bioinformatics; hub genes; miRNA target prediction; miRNA regulatory networks; miRNA-based biomarkers; artificial intelligence in miRNA research; multi-omics approaches
(This special issue belongs to the Section Molecular Informatics)
New Advances in Cystinosis from Basic to Clinical Research
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1935 | Submission Open
Keywords: cystinosis; kidney; Fanconi syndrome; muscles; eyes; autophagy; bioenergetics; inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Developing Chiral Products: New Progression in Separation, Synthesis, and Application
edited by István Ilisz
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1929 | Submission Open
Keywords: chirality; enantioselective separations; chiral selector molecules; chiral stationary phases; chiral sensors; enantiorecognition; chiral separation mechanisms
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
The Diversity of Life: Light to Heavy Metal Coordination Compounds of Biological Relevance
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1914 | Submission Open
Keywords: coordination compounds; metal-based drugs; antimicrobial; anti-inflammatory; antiviral agents; cancer therapy; drug delivery systems
(This special issue belongs to the Section Biochemistry)
Molecular Mechanisms of Tumorigenesis of Human and Animal Stem Cells
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1835 | Submission Open
Keywords: malignancy; stem cells; safety; chromosal aberrations; animal; human; teratoma assay; in vitro assays
(This special issue belongs to the Section Molecular Oncology)
Gynecological Oncology: From Molecular Basis to Therapy
edited by and Lars Hanker
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1765 | Submission Open
Keywords: gynecological oncology; molecular basis; targeted therapy; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms and Neural Circuits in Behavioral Neuroscience
edited by Matteo Di Segni and Rossella Ventura
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1710 | Submission Open
Keywords: behavioral neuroscience; neural circuits; psychopathology; neuroscience; drug addiction; depression; mental illness
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Research on Parasitic Infection
edited by Marcin Wiśniewski and
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1685 | Submission Open
Keywords: parasitic infections; host– parasite interactions; parasite genomics; drug-resistance mechanisms; transcriptomics; proteomics; diagnostic tools; immune evasion; therapeutic strategies
(This special issue belongs to the Section Molecular Microbiology)
Bioactive Natural Compounds in Neuroscience
edited by
submission deadline 20 Feb 2026 | Viewed by 1644 | Submission Open
Keywords: natural products; bioactive metabolites; secondary metabolites; neuronal development; neurotrophins; neuromedicine; neurodegeneration; memory disorders
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Vitiligo: From Mechanisms to Treatment Innovations
edited by Hyun Jeong Ju
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1639 | Submission Open
Keywords: autoimmune disease; cytokine signaling; depigmentation; immunotherapy; melanocyte regeneration; microbiome; oxidative stress; vitiligo
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research and Insight in Neurotransmission and Neuromodulation
edited by Miklos Jaszberenyi
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1631 | Submission Open
Keywords: histology; microanatomy; morphology; molecular biology; neurotransmitter; neuromodulator; neuropeptide; neurohormone; nervous system
(This special issue belongs to the Section Molecular Neurobiology)
Biomechanics and Molecular Research on Glioblastoma: 2nd Edition
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1619 | Submission Open
Keywords: GBM; molecular pathways; biomechanics; oncogene; cancer; microenvironment; drug targeting; diagnostic; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Molecular Interactions and Advanced Computational Methods for Biomolecular Systems
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1599 | Submission Open
Keywords: molecular interactions; biological systems; computational biology; protein– protein interactions; protein docking; bioinformatics; structural modeling; multiscale modeling techniques
(This special issue belongs to the Section Molecular Biophysics)
The Plant Cell Wall: Structural Dynamics, Functions, and Future Innovations submission deadline 20 Feb 2026 | 1 articles | Viewed by 1551 | Submission Open
Keywords: plant cell wall; biosynthesis; biomass; abiotic stress; biotic stress; renewable resources; biotechnology; climate change
(This special issue belongs to the Section Molecular Plant Sciences)
Advanced Research on Plant-Derived Products in the Service of Immune Regulation submission deadline 20 Feb 2026 | 1 articles | Viewed by 1520 | Submission Open
Keywords: plant bioactive compound; inflammation; immunity; cytokine; chronic disease
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Toxicity of Bisphenol A and Its Analogs
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1411 | Submission Open
Keywords: bisphenols; endocrine disruptors; bisphenol A and analogs; toxicology
(This special issue belongs to the Section Molecular Toxicology)
The Environment, Human Stress, and Gut Microbiome: A Triad in Disease Development
edited by and Halina Tkaczenko
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1359 | Submission Open
Keywords: gut microbiome stress interactions; environmental microbiome disease linkages; stress-driven microbiome dysbiosis; microbiome environment disease pathways; human microbiome stress responses; environmental stress disease mechanisms; gut microbiome oxidative stress interactions; environmental oxidative stress impacts; stress-driven microbiome oxidative imbalance; oxidative stress microbiome diseases; human oxidative stress pathways; oxidative stress disease mechanisms
(This special issue belongs to the Section Molecular Microbiology)
Novel Insights into Buckwheat Reproductive Biology
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1352 | Submission Open
Keywords: antioxidant properties; biotechnological methods; embryology; seed chemical composition; yield
(This special issue belongs to the Section Molecular Plant Sciences)
Cancer Progression and Therapeutic Resistance Mechanisms
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1324 | Submission Open
Keywords: cancer drug resistance; growth factors; DNA repair; miRNAs; ABC transporters; cancer stem cells; extracellular vesicles; circulating cancer cells; circulating cancer DNA; liquid biopsies; natural anticancer compounds
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms Underlying Skin Diseases
edited by Maria Lucia Dell'Anna
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1303 | Submission Open
Keywords: pigmentation; lipid signaling; immune cells; inflammation; skin barrier; oxidative damage; mitochondria
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Metabolic Dynamics and Immune Surveillance in the Tumor Microenvironment
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1277 | Submission Open
Keywords: cancer; TME; metabolism; immune cells; signaling pathway; therapy
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Health Targeting Cardiovascular and Cerebrovascular Diseases: Molecular Aspects
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1247 | Submission Open
Keywords: cardiovascular disease; cerebrovascular disease; cell therapy; gene therapy; extracellular vesicles; regenerative medicine; brain– heart axis; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neuromodulatory Effects of Serotonin, 2nd Edition
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1220 | Submission Open
Keywords: neuromodulation; Serotonin; pain research; cognition; emotions; depression; anxiety; GBM
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms Linking Obesity to Atherosclerosis Pathogenesis
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1145 | Submission Open
Keywords: obesity; overweight; atherosclerosis; coronary artery disease; obesity paradox; body mass index; visceral fat
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights in Biomodelling
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 1030 | Submission Open
Keywords: biomodelling; biomathematics; bioinformatics; biostatistics; biophysics; theoretical biology; theoretical ecology; mathematical biology; theoretical physics; physical chemistry
(This special issue belongs to the Section Molecular Informatics)
Cardiovascular Research: From Molecular Mechanisms to Novel Therapies
edited by Piotr Musiałek, Monika M. Gladká and Lukasz Tekieli
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1024 | Submission Open
Keywords: cardiovascular diseases; cardiovascular repair and regeneration; molecular cardiology; gene and stem cell therapy; drug and gene delivery; advanced imaging; biomarkers; tissue engineering; thrombosis and clotting abnormalities; animal models of human disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Algae-Derived Bioactives: Key Molecular Interactions Govern High-Value Applications
edited by Evan Stephens and Kirsten Heimann
submission deadline 20 Feb 2026 | 2 articles | Viewed by 1009 | Submission Open
Keywords: microalgae; macroalgae; cyanobacteria; bioactive compounds; health and nutrition; algal food products; market analysis
(This special issue belongs to the Section Molecular Microbiology)
Advances in Heparin, Heparan Sulfate and Heparanase, 2nd Edition
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 994 | Submission Open
Keywords: allergy; angiogenesis; cancer metastasis; cellular trafficking; exosome; fibrosis; glycocalyx; glycosaminoglycans; heparan sulfate; heparanase; heparin; immune responses; inflammation; inbibitor development; sepsis/SIRS (systemic inflammatory response syndrome); sulfatase; viral infections
(This special issue belongs to the Section Macromolecules)
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