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Molecular Diagnosis and Treatment of Migraine

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 1519

Special Issue Editor


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Guest Editor
Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil
Interests: migraine; pathophysiology; diagnostics; therapy; molecular mechanisms

Special Issue Information

Dear Colleagues,

Migraine is the most common headache in medical care units and the most studied headache type. Its pathophysiology still needs to be completed despite the recently discovered mechanisms. The improvement in the knowledge of migraine pathophysiology has permitted the development of new possible specific-target therapies, which may result in more effective outcomes for patients.

This Special Issue of the International Journal of Molecular Sciences aims to provide an advanced forum for molecular biology studies, reporting on recent advances in migraine treatment regarding molecular mechanisms.

We are pleased to invite you to contribute your studies and research in order to advance the understanding of the molecular pathophysiology of migraine and its implication in its treatment.

Original studies regarding CGRP, PACAP, TRP-ion channels, and 5-HT molecular mechanisms and their involvement in migraine treatment are welcome.

I look forward to receiving your contributions.

Prof. Dr. Fabiola Dach
Guest Editor

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Keywords

  • migraine
  • pathophysiology
  • diagnostics
  • therapy
  • molecular mechanisms

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Published Papers (1 paper)

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Research

12 pages, 424 KB  
Article
CACNA1A Genetic Variants and Their Potential Involvement in Migraine Pathogenesis
by Oliwia Szymanowicz, Bartosz Słowikowski, Joanna Poszwa, Ulyana Goutor, Małgorzata Wiszniewska, Paweł P. Jagodziński, Wojciech Kozubski and Jolanta Dorszewska
Int. J. Mol. Sci. 2025, 26(16), 8083; https://doi.org/10.3390/ijms26168083 - 21 Aug 2025
Viewed by 1094
Abstract
Migraine is a prevalent neurological disorder that affects over 1 billion individuals worldwide. The pathogenesis of migraine remains incompletely understood, though evidence suggests a multifactorial etiology involving genetic factors. The CACNA1A gene has been implicated in rare forms of Familial Hemiplegic Migraine (FHM). [...] Read more.
Migraine is a prevalent neurological disorder that affects over 1 billion individuals worldwide. The pathogenesis of migraine remains incompletely understood, though evidence suggests a multifactorial etiology involving genetic factors. The CACNA1A gene has been implicated in rare forms of Familial Hemiplegic Migraine (FHM). This study aimed to investigate the role of CACNA1A variants in individuals with and without a family history of migraine. We genotyped 150 subjects (100 migraine patients: 50 with migraine without aura (MO), 50 with migraine with aura (MA) and 50 controls) for six CACNA1A variants using Sanger sequencing. Statistical analyses were performed in Statistica (p < 0.05). The CADD v1.7 model was used to assess the potential pathogenicity of novel variants. Three variants described in databases (rs10405121, rs894252513, and rs1012663275) and three novel variants (ch19:13228374 G > C, ch19:13228428 G > C, and ch19:13228348 A > T) were identified. The rs10405121 variant was associated with both migraine types, with the homozygous AA genotype exclusively found in familial cases. Abnormal genotype of rs894252513 and rs1012663275 were detected only in familial cases with MO. The novel variants were observed exclusively in patients with a family history of migraine, suggesting their potential relevance to inherited migraine pathogenesis. Novel variants may contribute to migraine pathogenesis by altering calcium channel function and lowering the threshold for cortical spreading depression (CSD). Full article
(This article belongs to the Special Issue Molecular Diagnosis and Treatment of Migraine)
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