Molecular Insights into Heart Failure: From Bench to Bedside
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 February 2026 | Viewed by 1317
Special Issue Editor
Interests: biomarkers; heart failure; ischemic heart disease; preserved ejection fraction; cardiology; fibrosis; inflammation; non-coding RNA
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Significant progress has been made in the understanding of how molecular processes regulate cardiac function and how disruptions in these processes contribute to heart failure. However, there are still some significant gaps in the understanding of disease mechanisms, and further research is needed.
This Special Issue aims to explore the intricate molecular mechanisms that underlie heart failure, bridging the gap between basic research and clinical applications.
Key themes include:
- Molecular Pathways: This issue aims to examine the complex molecular pathways involved in cardiac hypertrophy, calcium homeostasis, and immune activation during heart failure. We want to highlight the roles of key molecular players, such as signaling molecules, transcriptional regulators, and microRNAs;
- Translational Research: A strong focus is placed on translating molecular insights into clinical applications, aiming to improve the diagnosis, prognosis, and treatment of heart failure through the development of novel therapeutic targets and strategies based on molecular understanding;
- Clinical Relevance: This issue addresses the clinical implications of molecular findings, discussing how these insights can be used to personalize medicine and improve patient outcomes.
It also addresses the importance of understanding the molecular differences within different types of heart failure, such as heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF).
In conclusion, this Special Issue aims to provide a comprehensive overview of the latest advancements in molecular research related to heart failure, highlighting the crucial role of these insights in advancing clinical practice.
Dr. Nadia Aspromonte
Guest Editor
Manuscript Submission Information
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Keywords
- heart failure
- cardiac biomarkers
- medical therapy
- molecular pathways
- prognosis
- target therapy
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