Advances in Metabolic Phenotypes of Pediatric Obesity
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 22 August 2025 | Viewed by 831
Special Issue Editor
Interests: metabolic diseases epidemiology; molecular biomarkers; obesity; diabetes; pancreatic neuroendocrine tumors; insulin resistance; obesity phenotypes
Special Issue Information
Dear Colleagues,
Obesity is the most prevalent metabolic disorder during childhood and adolescence, causing serious short- and long-term adverse health outcomes and comorbidities.
Cardiometabolic phenotypes of obesity in the pediatric population represent different subgroups characterized by specific clinical and biological features, which may influence the response to treatments and the long-term prognosis. However, despite the high prevalence of childhood obesity and atypical obesity phenotypes, the exact etiology is poorly understood and there is still debate regarding the molecular pathways, the biological biomarkers, the diagnostic threshold to apply for identification of the cardiometabolic phenotypes of pediatric obesity, and the optimal therapeutic strategies.
In recent years, new biochemical and molecular biomarkers, such as genetic variants, DNA methylation, specific miRNAs, microbiota and microbial metabolites, metabolomic profiles, and the entero-insular axis, have received great interest in the diagnosis and prognosis of childhood obesity phenotypes.
This Special Issue is dedicated to the impact of the microbiota and genetic, epigenetic and endocrine–metabolic factors on the pathogenesis and diagnosis of pediatric obesity phenotypes. We welcome all studies that help to identify future diagnostic approaches for the detection of cardiometabolic phenotypes related to obesity and that evaluate personalized and effective nutritional and pharmacological strategies for the prevention and management of childhood obesity.
Dr. Simona Georgiana Popa
Guest Editor
Manuscript Submission Information
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Keywords
- cardiometabolic phenotypes of pediatric obesity
- metabolomic profiles
- microbiota
- entero-insular axis
- adipocytokines
- precision therapy
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