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Molecular Research on Dyslipidemia

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 1947

Special Issue Editors


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Guest Editor
Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia
Interests: lipoprotein metabolism; cholesterol homeostasis; non-cholesterol sterols; sphingolipids; lipid biomarkers; dyslipidemia in pregnancy
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia
Interests: lipids; lipoproteins; atherosclerosis; diabetes; biomarkers; laboratory diagnostics; medical biochemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Dyslipidemia has long been recognized as a key contributor to cardiometabolic diseases such as atherosclerosis, obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease. Its role is also increasingly acknowledged in other chronic diseases, including malignancies. Furthermore, dyslipidemia is an inevitable component of certain physiological states, such as pregnancy.

Although many clinical and laboratory aspects of dyslipidemia have been well explored, significant gaps remain in our understanding of the molecular mechanisms underlying lipid dysregulation. In this Special Issue, we invite original research articles and reviews focusing on the metabolism and function of specific lipid moieties. We particularly welcome studies that investigate the molecular mechanisms driving lipid synthesis, transport, and degradation, as well as the roles of key regulatory genes and epigenetic factors in maintaining lipid homeostasis. Studies employing advanced methodologies, including lipidomics, transcriptomics, and metabolomics, are especially encouraged.

With this Special Issue, we aim to improve the understanding of the molecular basis of dyslipidemia and identify potential novel biomarkers and therapeutic targets for the personalized approach to the prevention and management of dyslipidemia-associated diseases.

We look forward to your valuable contributions.

Prof. Dr. Aleksandra Zeljkovic
Prof. Dr. Jelena Vekić
Guest Editors

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Keywords

  • dyslipidemia
  • chronic non-communicable diseases
  • dysregulation of lipid homeostasis
  • genetic and epigenetic regulation
  • lipidomics in personalized medicine
  • lipid biomarkers

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Published Papers (2 papers)

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Research

21 pages, 681 KB  
Article
Atherogenic Dyslipidemia and Its Association with FTO Gene Polymorphisms in Working Perimenopausal Women
by Astrid Lorena Urbano Cano, Rosa Elvira Álvarez Rosero and Yamil Liscano
Int. J. Mol. Sci. 2025, 26(22), 10915; https://doi.org/10.3390/ijms262210915 - 11 Nov 2025
Viewed by 787
Abstract
Atherogenic dyslipidemia (AD) is a high-risk phenotype for cardiovascular disease, characterized by elevated triglycerides, increased small dense low-density lipoprotein cholesterol (sdLDL-C), and frequently coexisting hypertension. Although FTO gene variants have been implicated in lipid dysregulation, their role in AD among Latin American women [...] Read more.
Atherogenic dyslipidemia (AD) is a high-risk phenotype for cardiovascular disease, characterized by elevated triglycerides, increased small dense low-density lipoprotein cholesterol (sdLDL-C), and frequently coexisting hypertension. Although FTO gene variants have been implicated in lipid dysregulation, their role in AD among Latin American women remains poorly defined. We conducted a case–control study in 219 working perimenopausal women (97 AD cases and 122 controls). Sociodemographic, clinical, and biochemical variables were assessed. Three FTO SNPs (rs9939609, rs9940128, and rs8050136) were genotyped. Associations were evaluated using logistic regression models adjusted for age and BMI, with gene–environment interactions tested for smoking. Linkage disequilibrium (LD) and haplotype analyses were also performed. Women with AD exhibited significantly higher triglycerides, LDL-C, and sdLDL-C, along with increased hypertension prevalence, but no differences in BMI or glycemia. Multivariable models identified LDL-C (aOR ≈ 8), triglycerides, sdLDL-C, and systolic blood pressure as the strongest determinants of AD. The rs8050136 AA genotype was associated with a fourfold higher risk (aOR = 4.12; 95% CI: 1.49–11.95, p = 0.007). Smoking independently doubled AD risk (aOR = 2.33) and amplified the effect of rs8050136. Adjusted haplotype analysis revealed that the A-A-A (aOR = 5.33; 95% CI: 1.42–20.00) and A-G-A combinations (aOR = 2.54; 95% CI: 1.01–6.38) were significantly associated with AD. FTO polymorphisms, particularly rs8050136 and the A-A-A and A-G-A haplotypes, contribute independently and supra-additively to AD risk. The observed gene–environment interaction with smoking emphasizes the multifactorial nature of AD and supports genotype-based risk stratification and targeted preventive strategies in precision cardiovascular medicine. Full article
(This article belongs to the Special Issue Molecular Research on Dyslipidemia)
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15 pages, 277 KB  
Article
Metabolic Dysfunction-Associated Steatotic Liver Disease Is Characterized by Enhanced Endogenous Cholesterol Synthesis and Impaired Synthesis/Absorption Balance
by Irena Frankovic, Aleksandra Zeljkovic, Ivana Djuricic, Ana Ninic, Jelena Vekic, Minja Derikonjic, Sanja Erceg, Ratko Tomasevic, Milica Mamic, Milos Mitrovic and Tamara Gojkovic
Int. J. Mol. Sci. 2025, 26(15), 7462; https://doi.org/10.3390/ijms26157462 - 1 Aug 2025
Viewed by 788
Abstract
Cholesterol accumulation plays a significant role in the pathogenesis of metabolic-dysfunction-associated steatotic liver disease (MASLD), yet changes in cholesterol homeostasis in MASLD remain insufficiently investigated. This study aimed to examine alterations in cholesterol synthesis and absorption by measuring plasma levels of endogenous cholesterol [...] Read more.
Cholesterol accumulation plays a significant role in the pathogenesis of metabolic-dysfunction-associated steatotic liver disease (MASLD), yet changes in cholesterol homeostasis in MASLD remain insufficiently investigated. This study aimed to examine alterations in cholesterol synthesis and absorption by measuring plasma levels of endogenous cholesterol precursors (as markers of synthesis) and phytosterols (as indicators of absorption). A total of 124 MASLD patients and 43 healthy individuals were included. Our results showed higher plasma concentrations of lathosterol in the MASLD group (p = 0.006), in parallel with comparable concentrations of desmosterol (p = 0.472) and all analyzed phytosterols in both groups. Correlation analysis showed that both lathosterol and desmosterol were positively associated with non-invasive hepatic steatosis indices: FLI, HSI, and TyG index (p < 0.01, p < 0.01, and p < 0.05, respectively). Multivariate linear regression further confirmed that these synthesis markers remained significant predictors of FLI (p = 0.010), HSI (p = 0.013), and TyG index (p = 0.002), even after adjusting for other relevant variables. These findings indicate that MASLD is associated with a shift in cholesterol homeostasis towards enhanced endogenous cholesterol synthesis. Full article
(This article belongs to the Special Issue Molecular Research on Dyslipidemia)
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