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Molecular Mechanisms Underlying Skin Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 350

Special Issue Editor


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Guest Editor
Laboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatological Institute IRCCS, 00144 Rome, Italy
Interests: oxidsativer stress; lipid-mediated signaling; pigmentation disorders; flow citometry; cytomic; hair follicle; primary cell colture; dendritic cells; immunology; mitochondrial impairment; cellular metabolism; vitiligo; dermatitis

Special Issue Information

Dear Colleagues,

The aim of this Special Issue is to focus on molecular processes underlying the dysregulation leading to skin diseases. Given the wide landscape of the skin world, a multidisciplinary approach is needed to gain knowledge about skin diseases. However, despite the large spectrum of diseases affecting the skin, this Special Issue aims to point to those diseases with a relevant inflammatory component, looking for the metabolic pathways leading to inflammatory and pigmentary disorders.

Preclinical studies based on traditional and 3D innovative in vitro models, as well as the omic approach, are encouraged. This Special Issue calls on researchers to submit original studies helping to better understand how the metabolic processes underlying the physiological beahvior are deregulated in pathological conditions. The dissection of the molecular mechanisms underlying the skin’s disregulated metabolisms will give the biological basis to improve even the general management of the different diseases.

In this Special Issue, original research articles and critical reviews on the molecular aspects of skin diseases are welcome.

Dr. Maria Lucia Dell'Anna
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • pigmentation
  • lipid signaling
  • immune cells
  • inflammation
  • skin barrier
  • oxidative damage
  • mitochondria

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Published Papers (1 paper)

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Review

16 pages, 418 KB  
Review
Matrix Metalloproteinases in Inflammatory Dermatoses
by Joanna Czerwińska and Agnieszka Owczarczyk-Saczonek
Int. J. Mol. Sci. 2025, 26(21), 10319; https://doi.org/10.3390/ijms262110319 - 23 Oct 2025
Viewed by 99
Abstract
Matrix metalloproteinases (MMPs) are endopeptidases that help maintain tissue homeostasis. Dysregulation of MMP secretion or activity, along with issues in their natural regulators, contributes to the development of many disorders, including autoimmune skin diseases. This article provides a comprehensive review of current research [...] Read more.
Matrix metalloproteinases (MMPs) are endopeptidases that help maintain tissue homeostasis. Dysregulation of MMP secretion or activity, along with issues in their natural regulators, contributes to the development of many disorders, including autoimmune skin diseases. This article provides a comprehensive review of current research on MMP biology, their physiological functions, and disease-specific evidence in dermatology. Based on available English-language studies, we discuss key papers with important findings and the latest systematic reviews from PubMed. Additionally, a comparison, synthesis, and summary of reported results are included to highlight the specific role of MMPs in dermatology and to identify research gaps that need to be addressed for developing and using MMPs as potential biomarkers in skin disease pathophysiology. Full article
(This article belongs to the Special Issue Molecular Mechanisms Underlying Skin Diseases)
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