Molecular Mechanisms of Tumorigenesis of Human and Animal Stem Cells
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 20 August 2025 | Viewed by 689
Special Issue Editor
Interests: pluripotent stem cells; cardiology; mouse models; gene therapy; nuclear reprogramming
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Human and animal pluripotent stem cells (hPSCs) often develop genetic abnormalities during in vitro culture. These genetic changes are thought to give mutant cells a growth advantage. However, the full implications of these abnormalities on the development of malignancies and the safety of hPSCs for future applications remain unclear.
Pluripotent stem cells (PSCs), including both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), have become important tools in biomedical research. They are used in disease modeling and new therapies. Despite their potential, growing concerns exist about the spontaneous mutations and large-scale chromosomal aberrations these cells can acquire during extended culture. Although an ongoing research and debate topic, multiple studies have indicated that these genetic changes often affect genes crucial for cell cycle regulation, possibly leading to a growth advantage for aberrant hPSCs and an increased risk of malignancy in vivo.
Therefore, a deeper understanding of the onset and consequences of these chromosomal aberrations and single-nucleotide mutations is essential. This knowledge is necessary to ensure the safety and effectiveness of hPSC-derived products for therapeutic uses and their reliability in tissue and disease modeling. This need is underscored by the guidelines from the International Society for Stem Cell Research (2023a) and the FDA’s safety testing guidelines for human allogeneic cells used in cell-based medical products (https://www.fda.gov/regulatory-information/search-fda-guidance-documents/safety-testing-human-allogeneic-cells-expanded-use-cell-based-medical-products).
Prof. Dr. Daniela Salvatori
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- malignancy
- stem cells
- safety
- chromosal aberrations
- animal
- human
- teratoma assay
- in vitro assays
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
