Molecular Mechanisms and Therapeutic Targets in Cardiometabolic Disorders

Dear Colleagues,

Cardiovascular disease (CVD) is a global challenge in modern society. Significant progress has been made in the pathophysiology of atherosclerotic lesion formation and complications such as myocardial infarction, stroke, and peripheral vascular disease. Yet, despite these advances, therapeutic options that can significantly reduce morbidity and mortality remain limited, indicating that the mechanism of atherosclerosis needs further elucidation. Therefore, understanding the molecular mechanisms and discovering novel therapeutic targets for atherosclerosis are urgently needed for the development of effective treatments for heart diseases.
Understanding the mechanisms involved in the development of atherosclerosis is challenging due to the complexity of today’s picture of the pathogenesis of atherosclerosis.
The molecular factors of atherosclerosis including renin–angiotensin signaling, vascular endothelial injury, lipid accumulation, smooth muscle cell phenotypic transition, macrophage infiltration, and inflammation alone or in combination contribute to the onset and progress of the atherosclerotic injuries and obesity. Metabolic dysfunctions with the clustering of risk factors are key factors that greatly worsen the atherosclerotic processes. In this Special Issue, we encourage submissions that identify the possible mechanisms for the prevention of progression of atherosclerosis. Clinical research for the early diagnosis and prognosis of cardiometabolic obesity-related diseases will also be welcomed.
We welcome submissions focusing on but not limited to topics mentioned below:

1. Role of vascular endothelial injury in the development of atherosclerosis.
2. Regulation of the inflammatory response in atherosclerosis.
3. Novel molecular factors as potential targets in atherosclerosis treatment.
4. Clinical research on novel biomarkers for the early diagnosis and prognosis of cardiac diseases.
5. Obesity and other dysmetabolic conditions and cardiovascular diseases: biomarkers and new drugs.

Prof. Dr. Massimiliano M. Corsi Romanelli
Prof. Dr. Pietro Formisano
Guest Editors

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• atherosclerosis
• angiotensin
• endothelial cell
• inflammation
• biomarkers
• gLP-1
• sT-2