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Advances in Pathogenesis and Treatment of Skin Cancer (2nd Edition)

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 495

Special Issue Editors


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Guest Editor
IRCCS Istituto Dermatologico San Gallicano, 00144 Rome, Italy
Interests: skin inflammatory response; cross-talk among epidermal and dermal cells in pigmentary disorders; the role of nuclear receptors in the protective response against UV; skin cancer
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
IRCCS Istituto Dermatologico San Gallicano, 00144 Rome, Italy
Interests: melanocytes; melanoma cells; alpha-MSH; MC1R; MC1R signal transduction pathways
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Skin cancer includes various types of skin tumors, such as melanoma, basal cell and squamous cell carcinomas, cutaneous lymphomas, and other rare diseases, which have very different etiologies, incidences, therapeutic approaches, and outcomes. The incidence of skin cancers is steadily increasing, representing a major public health concern. In recent years, significant efforts have been made to develop effective therapeutic options, although several questions remain open. We welcome research contributions that focus on understanding the molecular pathways, biomarkers, oxidative stress, and skin microenvironment that are involved in the onset and progression of skin cancers. Exploring the mechanisms of etiopathogenesis may contribute to developing new and more effective therapeutic approaches for the prevention and treatment of skin cancer. Please note that pre-clinical and clinical contributions with biomolecular approaches will also be considered.

Dr. Enrica Flori
Dr. Giorgia Cardinali
Dr. Vittoria Maresca
Guest Editors

Manuscript Submission Information

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Keywords

  • melanoma
  • squamous cell carcinoma
  • basal cell carcinoma
  • tumor microenvironment
  • epithelial–mesenchymal transition (EMT) process
  • ultraviolet radiation
  • oxidative stress
  • bioactive modulators
  • signal transduction pathways

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Published Papers (1 paper)

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Research

15 pages, 913 KiB  
Article
Gray-Horse Melanoma—A Wolf in Sheep’s Clothing
by Daniela M. Brodesser, Karin Schlangen, Alexandro Rodríguez-Rojas, Benno Kuropka, Pavlos G. Doulidis, Sabine Brandt and Barbara Pratscher
Int. J. Mol. Sci. 2025, 26(14), 6620; https://doi.org/10.3390/ijms26146620 - 10 Jul 2025
Viewed by 282
Abstract
Malignant melanoma (MM) affects not only humans but also animals, with gray horses being particularly predisposed to acquiring the disease. Multiomics have greatly advanced the understanding of human MM. In contrasty little is known regarding the pathogenesis of gray-horse melanoma and the unique [...] Read more.
Malignant melanoma (MM) affects not only humans but also animals, with gray horses being particularly predisposed to acquiring the disease. Multiomics have greatly advanced the understanding of human MM. In contrasty little is known regarding the pathogenesis of gray-horse melanoma and the unique phenomenon of melanoma “dormancy” in some animals. To help close this gap in knowledge, melanoma tissue and intact skin collected from gray horses were subjected to transcriptome analysis using RNAseq. In the next step, cultured primary tumor cells and normal skin fibroblasts were established from gray horses, and their protein expression profiles were determined. The obtained data unambiguously identified gray-horse melanoma (ghM) as a malignant tumor, as reflected by the overrepresentation of pathways typically activated in human melanoma and other human cancers. These included the RAS/RAF/MAPK, the IRS/IGF1R, and the PI3K/AKT signaling networks. In addition, the obtained data suggest that the key molecules RAC1, RAS, and BRAF, which are frequently mutated in human melanoma, may also contain activating mutations in ghM, whilst PTEN may harbor loss-of-function mutations. This issue will be subject to downstream analyses determining the mutational status in ghM to further advance the understanding of this frequent disease in gray horses. Full article
(This article belongs to the Special Issue Advances in Pathogenesis and Treatment of Skin Cancer (2nd Edition))
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